438 related articles for article (PubMed ID: 15182183)
1. Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis.
Strader MB; Chopra S; Jackson M; Smiley RD; Stinnett L; Wu J; Howell EE
Biochemistry; 2004 Jun; 43(23):7403-12. PubMed ID: 15182183
[TBL] [Abstract][Full Text] [Related]
2. Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase.
Hicks SN; Smiley RD; Hamilton JB; Howell EE
Biochemistry; 2003 Sep; 42(36):10569-78. PubMed ID: 12962480
[TBL] [Abstract][Full Text] [Related]
3. Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase.
Strader MB; Smiley RD; Stinnett LG; VerBerkmoes NC; Howell EE
Biochemistry; 2001 Sep; 40(38):11344-52. PubMed ID: 11560482
[TBL] [Abstract][Full Text] [Related]
4. Calorimetric studies of ligand binding in R67 dihydrofolate reductase.
Jackson M; Chopra S; Smiley RD; Maynord PO; Rosowsky A; London RE; Levy L; Kalman TI; Howell EE
Biochemistry; 2005 Sep; 44(37):12420-33. PubMed ID: 16156655
[TBL] [Abstract][Full Text] [Related]
5. The tail wagging the dog: insights into catalysis in R67 dihydrofolate reductase.
Kamath G; Howell EE; Agarwal PK
Biochemistry; 2010 Oct; 49(42):9078-88. PubMed ID: 20795731
[TBL] [Abstract][Full Text] [Related]
6. Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein.
Bradrick TD; Beechem JM; Howell EE
Biochemistry; 1996 Sep; 35(35):11414-24. PubMed ID: 8784197
[TBL] [Abstract][Full Text] [Related]
7. A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition.
Park H; Bradrick TD; Howell EE
Protein Eng; 1997 Dec; 10(12):1415-24. PubMed ID: 9543003
[TBL] [Abstract][Full Text] [Related]
8. Effects of temperature and viscosity on R67 dihydrofolate reductase catalysis.
Chopra S; Lynch R; Kim SH; Jackson M; Howell EE
Biochemistry; 2006 May; 45(21):6596-605. PubMed ID: 16716070
[TBL] [Abstract][Full Text] [Related]
9. R67, the other dihydrofolate reductase: rational design of an alternate active site configuration.
Feng J; Goswami S; Howell EE
Biochemistry; 2008 Jan; 47(2):555-65. PubMed ID: 18085798
[TBL] [Abstract][Full Text] [Related]
10. Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore.
Smiley RD; Stinnett LG; Saxton AM; Howell EE
Biochemistry; 2002 Dec; 41(52):15664-75. PubMed ID: 12501195
[TBL] [Abstract][Full Text] [Related]
11. "Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69.
Stinnett LG; Smiley RD; Hicks SN; Howell EE
J Biol Chem; 2004 Nov; 279(45):47003-9. PubMed ID: 15333637
[TBL] [Abstract][Full Text] [Related]
12. Complementation between dimeric mutants as a probe of dimer-dimer interactions in tetrameric dihydrofolate reductase encoded by R67 plasmid of E. coli.
Dam J; Rose T; Goldberg ME; Blondel A
J Mol Biol; 2000 Sep; 302(1):235-50. PubMed ID: 10964572
[TBL] [Abstract][Full Text] [Related]
13. Further studies on the role of water in R67 dihydrofolate reductase.
Timson MJ; Duff MR; Dickey G; Saxton AM; Reyes-De-Corcuera JI; Howell EE
Biochemistry; 2013 Mar; 52(12):2118-27. PubMed ID: 23458706
[TBL] [Abstract][Full Text] [Related]
14. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.
Howell EE; Shukla U; Hicks SN; Smiley RD; Kuhn LA; Zavodszky MI
J Comput Aided Mol Des; 2001 Nov; 15(11):1035-52. PubMed ID: 11989624
[TBL] [Abstract][Full Text] [Related]
15. High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site.
Narayana N
Acta Crystallogr D Biol Crystallogr; 2006 Jul; 62(Pt 7):695-706. PubMed ID: 16790925
[TBL] [Abstract][Full Text] [Related]
16. Thermodynamics and solvent effects on substrate and cofactor binding in Escherichia coli chromosomal dihydrofolate reductase.
Grubbs J; Rahmanian S; DeLuca A; Padmashali C; Jackson M; Duff MR; Howell EE
Biochemistry; 2011 May; 50(18):3673-85. PubMed ID: 21462996
[TBL] [Abstract][Full Text] [Related]
17. Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase.
Duff MR; Chopra S; Strader MB; Agarwal PK; Howell EE
Biochemistry; 2016 Jan; 55(1):133-45. PubMed ID: 26637016
[TBL] [Abstract][Full Text] [Related]
18. Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations.
Hicks SN; Smiley RD; Stinnett LG; Minor KH; Howell EE
J Biol Chem; 2004 Nov; 279(45):46995-7002. PubMed ID: 15333636
[TBL] [Abstract][Full Text] [Related]
19. A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase.
Chopra S; Dooling RM; Horner CG; Howell EE
J Biol Chem; 2008 Feb; 283(8):4690-8. PubMed ID: 18086667
[TBL] [Abstract][Full Text] [Related]
20. Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Krahn JM; Jackson MR; DeRose EF; Howell EE; London RE
Biochemistry; 2007 Dec; 46(51):14878-88. PubMed ID: 18052202
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
