BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

285 related articles for article (PubMed ID: 15185396)

  • 1. Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.
    Uhlmann EJ; Li W; Scheidenhelm DK; Gau CL; Tamanoi F; Gutmann DH
    Glia; 2004 Aug; 47(2):180-8. PubMed ID: 15185396
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
    Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J
    Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rheb binds and regulates the mTOR kinase.
    Long X; Lin Y; Ortiz-Vega S; Yonezawa K; Avruch J
    Curr Biol; 2005 Apr; 15(8):702-13. PubMed ID: 15854902
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.
    Shah OJ; Wang Z; Hunter T
    Curr Biol; 2004 Sep; 14(18):1650-6. PubMed ID: 15380067
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes.
    Jansen LA; Uhlmann EJ; Crino PB; Gutmann DH; Wong M
    Epilepsia; 2005 Dec; 46(12):1871-80. PubMed ID: 16393152
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.
    Jaeschke A; Hartkamp J; Saitoh M; Roworth W; Nobukuni T; Hodges A; Sampson J; Thomas G; Lamb R
    J Cell Biol; 2002 Oct; 159(2):217-24. PubMed ID: 12403809
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
    Uhlmann EJ; Apicelli AJ; Baldwin RL; Burke SP; Bajenaru ML; Onda H; Kwiatkowski D; Gutmann DH
    Oncogene; 2002 Jun; 21(25):4050-9. PubMed ID: 12037687
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.
    Nobukini T; Thomas G
    Novartis Found Symp; 2004; 262():148-54; discussion 154-9, 265-8. PubMed ID: 15562827
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of the Rap1 GTPase in astrocyte growth regulation.
    Apicelli AJ; Uhlmann EJ; Baldwin RL; Ding H; Nagy A; Guha A; Gutmann DH
    Glia; 2003 May; 42(3):225-34. PubMed ID: 12673829
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex.
    Nellist M; Sancak O; Goedbloed MA; Rohe C; van Netten D; Mayer K; Tucker-Williams A; van den Ouweland AM; Halley DJ
    Eur J Hum Genet; 2005 Jan; 13(1):59-68. PubMed ID: 15483652
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle.
    MacLea KS; Abuhagr AM; Pitts NL; Covi JA; Bader BD; Chang ES; Mykles DL
    J Exp Biol; 2012 Feb; 215(Pt 4):590-604. PubMed ID: 22279066
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
    Li Y; Inoki K; Guan KL
    Mol Cell Biol; 2004 Sep; 24(18):7965-75. PubMed ID: 15340059
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.
    Banerjee S; Crouse NR; Emnett RJ; Gianino SM; Gutmann DH
    Proc Natl Acad Sci U S A; 2011 Sep; 108(38):15996-6001. PubMed ID: 21896734
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
    Karbowniczek M; Cash T; Cheung M; Robertson GP; Astrinidis A; Henske EP
    J Biol Chem; 2004 Jul; 279(29):29930-7. PubMed ID: 15150271
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rheb fills a GAP between TSC and TOR.
    Manning BD; Cantley LC
    Trends Biochem Sci; 2003 Nov; 28(11):573-6. PubMed ID: 14607085
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
    Finlay GA; Malhowski AJ; Liu Y; Fanburg BL; Kwiatkowski DJ; Toksoz D
    Cancer Res; 2007 Oct; 67(20):9878-86. PubMed ID: 17942919
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.
    Hsu YC; Chern JJ; Cai Y; Liu M; Choi KW
    Nature; 2007 Feb; 445(7129):785-8. PubMed ID: 17301792
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.
    Kwiatkowski DJ
    Cancer Biol Ther; 2003; 2(5):471-6. PubMed ID: 14614311
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
    Zhang Y; Gao X; Saucedo LJ; Ru B; Edgar BA; Pan D
    Nat Cell Biol; 2003 Jun; 5(6):578-81. PubMed ID: 12771962
    [TBL] [Abstract][Full Text] [Related]  

  • 20. mTOR cascade activation distinguishes tubers from focal cortical dysplasia.
    Baybis M; Yu J; Lee A; Golden JA; Weiner H; McKhann G; Aronica E; Crino PB
    Ann Neurol; 2004 Oct; 56(4):478-87. PubMed ID: 15455405
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.