BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 15186859)

  • 1. Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Kerrigan JE; Li TK; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2004 Jul; 12(13):3731-42. PubMed ID: 15186859
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
    Singh SK; Ruchelman AL; Li TK; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 2003 May; 46(11):2254-7. PubMed ID: 12747798
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Zhu S; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5585-9. PubMed ID: 15482929
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Singh SK; Ray A; Wu X; Yang JM; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2004 Feb; 12(4):795-806. PubMed ID: 14759740
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
    Zhu S; Ruchelman AL; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2006 May; 14(9):3131-43. PubMed ID: 16412652
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
    Feng W; Satyanarayana M; Cheng L; Liu A; Tsai YC; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2008 Oct; 16(20):9295-301. PubMed ID: 18829334
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
    Ruchelman AL; Houghton PJ; Zhou N; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 2005 Feb; 48(3):792-804. PubMed ID: 15689163
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.
    Feng W; Satyanarayana M; Tsai YC; Liu AA; Liu LF; Lavoie EJ
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3570-2. PubMed ID: 18511275
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
    Satyanarayana M; Feng W; Cheng L; Liu AA; Tsai YC; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2008 Aug; 16(16):7824-31. PubMed ID: 18676151
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
    Sharma L; Tsai YC; Liu AA; Liu LF; LaVoie EJ
    Eur J Med Chem; 2009 Apr; 44(4):1471-6. PubMed ID: 19012996
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
    Chen K; Kuo SC; Hsieh MC; Mauger A; Lin CM; Hamel E; Lee KH
    J Med Chem; 1997 Jul; 40(14):2266-75. PubMed ID: 9216846
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
    Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
    J Med Chem; 1999 Feb; 42(3):446-57. PubMed ID: 9986716
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.
    Ruchelman AL; Singh SK; Ray A; Wu XH; Yang JM; Li TK; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2003 May; 11(9):2061-73. PubMed ID: 12670657
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3659-63. PubMed ID: 15203138
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
    Li TK; Houghton PJ; Desai SD; Daroui P; Liu AA; Hars ES; Ruchelman AL; LaVoie EJ; Liu LF
    Cancer Res; 2003 Dec; 63(23):8400-7. PubMed ID: 14679002
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Terbenzimidazoles: influence of 2"-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons.
    Kim JS; Yu C; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 1997 Aug; 40(18):2818-24. PubMed ID: 9288163
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.
    Dallavalle S; Gattinoni S; Mazzini S; Scaglioni L; Merlini L; Tinelli S; Beretta GL; Zunino F
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1484-9. PubMed ID: 18248813
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide.
    Feng W; Satyanarayana M; Tsai YC; Liu AA; Liu LF; LaVoie EJ
    Eur J Med Chem; 2009 Sep; 44(9):3433-8. PubMed ID: 19299037
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.
    Zhu S; Ruchelman AL; Zhou N; Liu AA; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2005 Dec; 13(24):6782-94. PubMed ID: 16153852
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.