487 related articles for article (PubMed ID: 15189355)
1. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
2. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Prokop S; Haass C; Steiner H
J Neurochem; 2005 Jul; 94(1):57-62. PubMed ID: 15953349
[TBL] [Abstract][Full Text] [Related]
3. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
4. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
[TBL] [Abstract][Full Text] [Related]
5. Reconstitution of gamma-secretase activity.
Edbauer D; Winkler E; Regula JT; Pesold B; Steiner H; Haass C
Nat Cell Biol; 2003 May; 5(5):486-8. PubMed ID: 12679784
[TBL] [Abstract][Full Text] [Related]
6. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
[TBL] [Abstract][Full Text] [Related]
7. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
8. The role of presenilin cofactors in the gamma-secretase complex.
Takasugi N; Tomita T; Hayashi I; Tsuruoka M; Niimura M; Takahashi Y; Thinakaran G; Iwatsubo T
Nature; 2003 Mar; 422(6930):438-41. PubMed ID: 12660785
[TBL] [Abstract][Full Text] [Related]
9. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
Edbauer D; Winkler E; Haass C; Steiner H
Proc Natl Acad Sci U S A; 2002 Jun; 99(13):8666-71. PubMed ID: 12048259
[TBL] [Abstract][Full Text] [Related]
10. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
Walker ES; Martinez M; Wang J; Goate A
J Neurochem; 2006 Jul; 98(1):300-9. PubMed ID: 16805816
[TBL] [Abstract][Full Text] [Related]
11. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
[TBL] [Abstract][Full Text] [Related]
12. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
[TBL] [Abstract][Full Text] [Related]
13. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; Wilson CA; Lee VM; Doms RW
Biochemistry; 2004 Mar; 43(12):3555-63. PubMed ID: 15035625
[TBL] [Abstract][Full Text] [Related]
14. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
15. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
Shiraishi H; Marutani T; Wang HQ; Maeda Y; Kurono Y; Takashima A; Araki W; Nishimura M; Yanagisawa K; Komano H
Genes Cells; 2006 Jan; 11(1):83-93. PubMed ID: 16371134
[TBL] [Abstract][Full Text] [Related]
16. Ubiquitin-proteasome pathway mediates degradation of APH-1.
He G; Qing H; Cai F; Kwok C; Xu H; Yu G; Bernstein A; Song W
J Neurochem; 2006 Dec; 99(5):1403-12. PubMed ID: 17059559
[TBL] [Abstract][Full Text] [Related]
17. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
[TBL] [Abstract][Full Text] [Related]
18. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
Laudon H; Winblad B; Näslund J
Physiol Behav; 2007 Sep; 92(1-2):115-20. PubMed ID: 17588625
[TBL] [Abstract][Full Text] [Related]
19. Assembly, trafficking and function of gamma-secretase.
Kaether C; Haass C; Steiner H
Neurodegener Dis; 2006; 3(4-5):275-83. PubMed ID: 17047368
[TBL] [Abstract][Full Text] [Related]
20. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
