These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Inoki K; Li Y; Zhu T; Wu J; Guan KL Nat Cell Biol; 2002 Sep; 4(9):648-57. PubMed ID: 12172553 [TBL] [Abstract][Full Text] [Related]
4. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. Smith EM; Finn SG; Tee AR; Browne GJ; Proud CG J Biol Chem; 2005 May; 280(19):18717-27. PubMed ID: 15772076 [TBL] [Abstract][Full Text] [Related]
5. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785 [TBL] [Abstract][Full Text] [Related]
6. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Tee AR; Fingar DC; Manning BD; Kwiatkowski DJ; Cantley LC; Blenis J Proc Natl Acad Sci U S A; 2002 Oct; 99(21):13571-6. PubMed ID: 12271141 [TBL] [Abstract][Full Text] [Related]
7. TSC2 mediates cellular energy response to control cell growth and survival. Inoki K; Zhu T; Guan KL Cell; 2003 Nov; 115(5):577-90. PubMed ID: 14651849 [TBL] [Abstract][Full Text] [Related]
8. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes. Brugarolas J; Kaelin WG Cancer Cell; 2004 Jul; 6(1):7-10. PubMed ID: 15261137 [TBL] [Abstract][Full Text] [Related]
9. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Shaw RJ; Kosmatka M; Bardeesy N; Hurley RL; Witters LA; DePinho RA; Cantley LC Proc Natl Acad Sci U S A; 2004 Mar; 101(10):3329-35. PubMed ID: 14985505 [TBL] [Abstract][Full Text] [Related]
10. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. Jaeschke A; Hartkamp J; Saitoh M; Roworth W; Nobukuni T; Hodges A; Sampson J; Thomas G; Lamb R J Cell Biol; 2002 Oct; 159(2):217-24. PubMed ID: 12403809 [TBL] [Abstract][Full Text] [Related]
11. Regulation of TSC2 by 14-3-3 binding. Li Y; Inoki K; Yeung R; Guan KL J Biol Chem; 2002 Nov; 277(47):44593-6. PubMed ID: 12364343 [TBL] [Abstract][Full Text] [Related]
12. Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway. Onda H; Crino PB; Zhang H; Murphey RD; Rastelli L; Gould Rothberg BE; Kwiatkowski DJ Mol Cell Neurosci; 2002 Dec; 21(4):561-74. PubMed ID: 12504590 [TBL] [Abstract][Full Text] [Related]
13. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Hawley SA; Boudeau J; Reid JL; Mustard KJ; Udd L; Mäkelä TP; Alessi DR; Hardie DG J Biol; 2003; 2(4):28. PubMed ID: 14511394 [TBL] [Abstract][Full Text] [Related]
14. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Li Y; Inoki K; Guan KL Mol Cell Biol; 2004 Sep; 24(18):7965-75. PubMed ID: 15340059 [TBL] [Abstract][Full Text] [Related]
15. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. Chan JA; Zhang H; Roberts PS; Jozwiak S; Wieslawa G; Lewin-Kowalik J; Kotulska K; Kwiatkowski DJ J Neuropathol Exp Neurol; 2004 Dec; 63(12):1236-42. PubMed ID: 15624760 [TBL] [Abstract][Full Text] [Related]
16. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Garami A; Zwartkruis FJ; Nobukuni T; Joaquin M; Roccio M; Stocker H; Kozma SC; Hafen E; Bos JL; Thomas G Mol Cell; 2003 Jun; 11(6):1457-66. PubMed ID: 12820960 [TBL] [Abstract][Full Text] [Related]
17. The tuberous sclerosis complex genes in tumor development. Mak BC; Yeung RS Cancer Invest; 2004; 22(4):588-603. PubMed ID: 15565817 [TBL] [Abstract][Full Text] [Related]
18. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Liu L; Cash TP; Jones RG; Keith B; Thompson CB; Simon MC Mol Cell; 2006 Feb; 21(4):521-31. PubMed ID: 16483933 [TBL] [Abstract][Full Text] [Related]
19. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Tripathi DN; Chowdhury R; Trudel LJ; Tee AR; Slack RS; Walker CL; Wogan GN Proc Natl Acad Sci U S A; 2013 Aug; 110(32):E2950-7. PubMed ID: 23878245 [TBL] [Abstract][Full Text] [Related]
20. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. Tee AR; Anjum R; Blenis J J Biol Chem; 2003 Sep; 278(39):37288-96. PubMed ID: 12867426 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]