BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

423 related articles for article (PubMed ID: 15235603)

  • 1. Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
    Chang S; Multani AS; Cabrera NG; Naylor ML; Laud P; Lombard D; Pathak S; Guarente L; DePinho RA
    Nat Genet; 2004 Aug; 36(8):877-82. PubMed ID: 15235603
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A mouse model of Werner Syndrome: what can it tell us about aging and cancer?
    Chang S
    Int J Biochem Cell Biol; 2005 May; 37(5):991-9. PubMed ID: 15743673
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
    Shimamoto A; Kagawa H; Zensho K; Sera Y; Kazuki Y; Osaki M; Oshimura M; Ishigaki Y; Hamasaki K; Kodama Y; Yuasa S; Fukuda K; Hirashima K; Seimiya H; Koyama H; Shimizu T; Takemoto M; Yokote K; Goto M; Tahara H
    PLoS One; 2014; 9(11):e112900. PubMed ID: 25390333
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
    Du X; Shen J; Kugan N; Furth EE; Lombard DB; Cheung C; Pak S; Luo G; Pignolo RJ; DePinho RA; Guarente L; Johnson FB
    Mol Cell Biol; 2004 Oct; 24(19):8437-46. PubMed ID: 15367665
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
    Laud PR; Multani AS; Bailey SM; Wu L; Ma J; Kingsley C; Lebel M; Pathak S; DePinho RA; Chang S
    Genes Dev; 2005 Nov; 19(21):2560-70. PubMed ID: 16264192
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).
    Sugimoto M
    Int J Mol Med; 2014 Feb; 33(2):247-53. PubMed ID: 24356923
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [Utilization of Werner syndrome mouse model in studying premature aging and tumor].
    Jia ST; Yang SH; Luo Y
    Yi Chuan; 2009 Aug; 31(8):785-90. PubMed ID: 19689938
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis.
    Brennan TA; Egan KP; Lindborg CM; Chen Q; Sweetwyne MT; Hankenson KD; Xie SX; Johnson FB; Pignolo RJ
    Dis Model Mech; 2014 May; 7(5):583-92. PubMed ID: 24626990
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains.
    Choi D; Whittier PS; Oshima J; Funk WD
    FASEB J; 2001 Apr; 15(6):1014-20. PubMed ID: 11292662
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency.
    Si X; Shao C; Li J; Jia S; Tang W; Zhang J; Yang J; Wu X; Luo Y
    Int J Biol Sci; 2018; 14(2):165-177. PubMed ID: 29483835
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis.
    Pignolo RJ; Suda RK; McMillan EA; Shen J; Lee SH; Choi Y; Wright AC; Johnson FB
    Aging Cell; 2008 Jan; 7(1):23-31. PubMed ID: 18028256
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.
    Orren DK
    Front Biosci; 2006 Sep; 11():2657-71. PubMed ID: 16720342
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hyper telomere recombination accelerates replicative senescence and may promote premature aging.
    Hagelstrom RT; Blagoev KB; Niedernhofer LJ; Goodwin EH; Bailey SM
    Proc Natl Acad Sci U S A; 2010 Sep; 107(36):15768-73. PubMed ID: 20798040
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells.
    Ariyoshi K; Suzuki K; Goto M; Watanabe M; Kodama S
    J Radiat Res; 2007 May; 48(3):219-31. PubMed ID: 17449919
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Telomeres and telomerase: basic science implications for aging.
    Ahmed A; Tollefsbol T
    J Am Geriatr Soc; 2001 Aug; 49(8):1105-9. PubMed ID: 11555075
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies.
    Agrelo R; Sutz MA; Setien F; Aldunate F; Esteller M; Da Costa V; Achenbach R
    Epigenetics; 2015; 10(4):329-41. PubMed ID: 25830902
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
    Lebel M; Cardiff RD; Leder P
    Cancer Res; 2001 Mar; 61(5):1816-9. PubMed ID: 11280729
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
    Wong KK; Maser RS; Bachoo RM; Menon J; Carrasco DR; Gu Y; Alt FW; DePinho RA
    Nature; 2003 Feb; 421(6923):643-8. PubMed ID: 12540856
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Werner syndrome protein at the crossroads of DNA repair and apoptosis.
    Comai L; Li B
    Mech Ageing Dev; 2004 Aug; 125(8):521-8. PubMed ID: 15336909
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Recent Advances in Understanding Werner Syndrome.
    Shamanna RA; Croteau DL; Lee JH; Bohr VA
    F1000Res; 2017; 6():1779. PubMed ID: 29043077
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.