670 related articles for article (PubMed ID: 15249583)
1. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Harrington LS; Findlay GM; Gray A; Tolkacheva T; Wigfield S; Rebholz H; Barnett J; Leslie NR; Cheng S; Shepherd PR; Gout I; Downes CP; Lamb RF
J Cell Biol; 2004 Jul; 166(2):213-23. PubMed ID: 15249583
[TBL] [Abstract][Full Text] [Related]
2. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.
Jaeschke A; Hartkamp J; Saitoh M; Roworth W; Nobukuni T; Hodges A; Sampson J; Thomas G; Lamb R
J Cell Biol; 2002 Oct; 159(2):217-24. PubMed ID: 12403809
[TBL] [Abstract][Full Text] [Related]
3. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.
Shah OJ; Wang Z; Hunter T
Curr Biol; 2004 Sep; 14(18):1650-6. PubMed ID: 15380067
[TBL] [Abstract][Full Text] [Related]
4. Insulin signaling during perinatal liver development in the rat.
Anand P; Boylan JM; Ou Y; Gruppuso PA
Am J Physiol Endocrinol Metab; 2002 Oct; 283(4):E844-52. PubMed ID: 12217903
[TBL] [Abstract][Full Text] [Related]
5. Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway.
Uddin S; Majchrzak B; Wang PC; Modi S; Khan MK; Fish EN; Platanias LC
Biochem Biophys Res Commun; 2000 Apr; 270(1):158-62. PubMed ID: 10733921
[TBL] [Abstract][Full Text] [Related]
6. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
Copps KD; Hançer NJ; Qiu W; White MF
J Biol Chem; 2016 Apr; 291(16):8602-17. PubMed ID: 26846849
[TBL] [Abstract][Full Text] [Related]
7. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
Takano A; Usui I; Haruta T; Kawahara J; Uno T; Iwata M; Kobayashi M
Mol Cell Biol; 2001 Aug; 21(15):5050-62. PubMed ID: 11438661
[TBL] [Abstract][Full Text] [Related]
8. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Garami A; Zwartkruis FJ; Nobukuni T; Joaquin M; Roccio M; Stocker H; Kozma SC; Hafen E; Bos JL; Thomas G
Mol Cell; 2003 Jun; 11(6):1457-66. PubMed ID: 12820960
[TBL] [Abstract][Full Text] [Related]
9. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.
Nobukini T; Thomas G
Novartis Found Symp; 2004; 262():148-54; discussion 154-9, 265-8. PubMed ID: 15562827
[TBL] [Abstract][Full Text] [Related]
10. Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
Batty IH; Fleming IN; Downes CP
Biochem J; 2004 May; 379(Pt 3):641-51. PubMed ID: 14769130
[TBL] [Abstract][Full Text] [Related]
11. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.
Zhang H; Cicchetti G; Onda H; Koon HB; Asrican K; Bajraszewski N; Vazquez F; Carpenter CL; Kwiatkowski DJ
J Clin Invest; 2003 Oct; 112(8):1223-33. PubMed ID: 14561707
[TBL] [Abstract][Full Text] [Related]
12. Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.
Hers I; Tavaré JM
Biochem J; 2005 Jun; 388(Pt 2):713-20. PubMed ID: 15713122
[TBL] [Abstract][Full Text] [Related]
13. Activation of insulin-like growth factor I receptor signaling pathway is critical for mouse plasma cell tumor growth.
Li W; Hyun T; Heller M; Yam A; Flechner L; Pierce JH; Rudikoff S
Cancer Res; 2000 Jul; 60(14):3909-15. PubMed ID: 10919668
[TBL] [Abstract][Full Text] [Related]
14. Dual regulation of upstream binding factor 1 levels by IRS-1 and ERKs in IGF-1-receptor signaling.
Sun H; Tu X; Liu M; Baserga R
J Cell Physiol; 2007 Sep; 212(3):780-6. PubMed ID: 17443674
[TBL] [Abstract][Full Text] [Related]
15. Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis.
Franch HA; Raissi S; Wang X; Zheng B; Bailey JL; Price SR
Am J Physiol Renal Physiol; 2004 Oct; 287(4):F700-6. PubMed ID: 15161606
[TBL] [Abstract][Full Text] [Related]
16. Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis.
Shah OJ; Hunter T
Mol Cell Biol; 2006 Sep; 26(17):6425-34. PubMed ID: 16914728
[TBL] [Abstract][Full Text] [Related]
17. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3.
O'Connor JC; Sherry CL; Guest CB; Freund GG
J Immunol; 2007 Jun; 178(11):6886-93. PubMed ID: 17513737
[TBL] [Abstract][Full Text] [Related]
18. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance.
Lee DF; Kuo HP; Chen CT; Wei Y; Chou CK; Hung JY; Yen CJ; Hung MC
Int J Mol Med; 2008 Nov; 22(5):633-8. PubMed ID: 18949383
[TBL] [Abstract][Full Text] [Related]
19. A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide.
Venters HD; Tang Q; Liu Q; VanHoy RW; Dantzer R; Kelley KW
Proc Natl Acad Sci U S A; 1999 Aug; 96(17):9879-84. PubMed ID: 10449788
[TBL] [Abstract][Full Text] [Related]
20. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells.
Kwiatkowski DJ; Zhang H; Bandura JL; Heiberger KM; Glogauer M; el-Hashemite N; Onda H
Hum Mol Genet; 2002 Mar; 11(5):525-34. PubMed ID: 11875047
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]