BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

95 related articles for article (PubMed ID: 15251442)

  • 1. Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting.
    Kametani F
    FEBS Lett; 2004 Jul; 570(1-3):73-6. PubMed ID: 15251442
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H; Maruyama K; Kametani F
    Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Abeta 11-40/42 production without gamma-secretase epsilon-site cleavage.
    Kume H; Kametani F
    Biochem Biophys Res Commun; 2006 Nov; 349(4):1356-60. PubMed ID: 16979587
    [TBL] [Abstract][Full Text] [Related]  

  • 4. gamma-Secretase can cleave amyloid precursor protein fragments independent of alpha- and beta-secretase pre-cutting.
    Kume H; Sekijima Y; Maruyama K; Kametani F
    Int J Mol Med; 2003 Jul; 12(1):57-60. PubMed ID: 12792809
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 6. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S; Sunyach C; Checler F
    J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
    FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
    Funamoto S; Morishima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; Ihara Y
    Biochemistry; 2004 Oct; 43(42):13532-40. PubMed ID: 15491160
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
    Irizarry MC; Deng A; Lleo A; Berezovska O; Von Arnim CA; Martin-Rehrmann M; Manelli A; LaDu MJ; Hyman BT; Rebeck GW
    J Neurochem; 2004 Sep; 90(5):1132-43. PubMed ID: 15312168
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH; Jeon SH; Zhang G; Olson GL; Chae CB
    J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM; Guss VL; Corsa JA; Loo A; Hansel SB; Zheng M; Munoz B; Srinivasan K; Wang B; Robertson BJ; Polson CT; Wang J; Roberts SB; Hendrick JP; Anderson JJ; Loy JK; Denton R; Verdoorn TA; Smith DW; Felsenstein KM
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
    Cater MA; McInnes KT; Li QX; Volitakis I; La Fontaine S; Mercer JF; Bush AI
    Biochem J; 2008 May; 412(1):141-52. PubMed ID: 18248325
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of peptides derived from BACE1 catalytic domain on APP processing.
    Yeon SW; Jeon YJ; Hwang EM; Kim TY
    Peptides; 2007 Apr; 28(4):838-44. PubMed ID: 17293005
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.
    Portelius E; Brinkmalm G; Tran AJ; Zetterberg H; Westman-Brinkmalm A; Blennow K
    Neurodegener Dis; 2009; 6(3):87-94. PubMed ID: 19229112
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.
    Fukumori A; Okochi M; Tagami S; Jiang J; Itoh N; Nakayama T; Yanagida K; Ishizuka-Katsura Y; Morihara T; Kamino K; Tanaka T; Kudo T; Tanii H; Ikuta A; Haass C; Takeda M
    Biochemistry; 2006 Apr; 45(15):4907-14. PubMed ID: 16605258
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.
    Stockley JH; O'Neill C
    Biochem Soc Trans; 2007 Jun; 35(Pt 3):574-6. PubMed ID: 17511655
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
    Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
    Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.
    Sato T; Tanimura Y; Hirotani N; Saido TC; Morishima-Kawashima M; Ihara Y
    FEBS Lett; 2005 May; 579(13):2907-12. PubMed ID: 15890346
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.
    Lichtenthaler SF; Beher D; Grimm HS; Wang R; Shearman MS; Masters CL; Beyreuther K
    Proc Natl Acad Sci U S A; 2002 Feb; 99(3):1365-70. PubMed ID: 11805291
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.