435 related articles for article (PubMed ID: 15252010)
21. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.
Drocourt L; Pascussi JM; Assenat E; Fabre JM; Maurel P; Vilarem MJ
Drug Metab Dispos; 2001 Oct; 29(10):1325-31. PubMed ID: 11560876
[TBL] [Abstract][Full Text] [Related]
22. The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.
Sugatani J; Yamakawa K; Tonda E; Nishitani S; Yoshinari K; Degawa M; Abe I; Noguchi H; Miwa M
Biochem Pharmacol; 2004 Mar; 67(5):989-1000. PubMed ID: 15104253
[TBL] [Abstract][Full Text] [Related]
23. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Jones SA; Moore LB; Shenk JL; Wisely GB; Hamilton GA; McKee DD; Tomkinson NC; LeCluyse EL; Lambert MH; Willson TM; Kliewer SA; Moore JT
Mol Endocrinol; 2000 Jan; 14(1):27-39. PubMed ID: 10628745
[TBL] [Abstract][Full Text] [Related]
24. Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.
LeCluyse EL
Chem Biol Interact; 2001 May; 134(3):283-9. PubMed ID: 11336976
[TBL] [Abstract][Full Text] [Related]
25. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S; Kurose K; Saito Y; Ozawa S; Hasegawa R; Komamura K; Ueno K; Kamakura S; Kitakaze M; Nakajima T; Matsumoto K; Akasawa A; Saito H; Sawada J
Drug Metab Dispos; 2004 Jan; 32(1):149-54. PubMed ID: 14709632
[TBL] [Abstract][Full Text] [Related]
26. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors.
Küblbeck J; Reinisalo M; Mustonen R; Honkakoski P
Eur J Pharm Sci; 2010 Jul; 40(4):263-72. PubMed ID: 20381613
[TBL] [Abstract][Full Text] [Related]
27. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
El-Sankary W; Bombail V; Gibson GG; Plant N
Drug Metab Dispos; 2002 Sep; 30(9):1029-34. PubMed ID: 12167569
[TBL] [Abstract][Full Text] [Related]
28. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
Casabar RC; Das PC; Dekrey GK; Gardiner CS; Cao Y; Rose RL; Wallace AD
Toxicol Appl Pharmacol; 2010 Jun; 245(3):335-43. PubMed ID: 20361990
[TBL] [Abstract][Full Text] [Related]
29. PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
Yu C; Ye S; Sun H; Liu Y; Gao L; Shen C; Chen S; Zeng S
Chem Biol Interact; 2009 Jan; 177(1):58-64. PubMed ID: 18805405
[TBL] [Abstract][Full Text] [Related]
30. Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application.
Nibourg GA; Huisman MT; van der Hoeven TV; van Gulik TM; Chamuleau RA; Hoekstra R
Liver Transpl; 2010 Sep; 16(9):1075-85. PubMed ID: 20818746
[TBL] [Abstract][Full Text] [Related]
31. The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor.
Wyde ME; Bartolucci E; Ueda A; Zhang H; Yan B; Negishi M; You L
Mol Pharmacol; 2003 Aug; 64(2):474-81. PubMed ID: 12869653
[TBL] [Abstract][Full Text] [Related]
32. Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
Maglich JM; Stoltz CM; Goodwin B; Hawkins-Brown D; Moore JT; Kliewer SA
Mol Pharmacol; 2002 Sep; 62(3):638-46. PubMed ID: 12181440
[TBL] [Abstract][Full Text] [Related]
33. Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.
Roth A; Looser R; Kaufmann M; Meyer UA
Pharmacogenet Genomics; 2008 Apr; 18(4):325-37. PubMed ID: 18334917
[TBL] [Abstract][Full Text] [Related]
34. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
[TBL] [Abstract][Full Text] [Related]
35. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
Kanno Y; Tanuma N; Yazawa S; Zhao S; Inaba M; Nakamura S; Nemoto K; Inouye Y
Drug Metab Dispos; 2016 Aug; 44(8):1158-63. PubMed ID: 27197997
[TBL] [Abstract][Full Text] [Related]
36. A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene.
Gamou T; Habano W; Terashima J; Ozawa S
Drug Metab Pharmacokinet; 2015 Apr; 30(2):188-97. PubMed ID: 25989892
[TBL] [Abstract][Full Text] [Related]
37. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
Tirona RG; Lee W; Leake BF; Lan LB; Cline CB; Lamba V; Parviz F; Duncan SA; Inoue Y; Gonzalez FJ; Schuetz EG; Kim RB
Nat Med; 2003 Feb; 9(2):220-4. PubMed ID: 12514743
[TBL] [Abstract][Full Text] [Related]
38. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.
Krausova L; Stejskalova L; Wang H; Vrzal R; Dvorak Z; Mani S; Pavek P
Biochem Pharmacol; 2011 Dec; 82(11):1771-80. PubMed ID: 21920351
[TBL] [Abstract][Full Text] [Related]
39. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.
Wang H; Faucette SR; Gilbert D; Jolley SL; Sueyoshi T; Negishi M; LeCluyse EL
Drug Metab Dispos; 2003 May; 31(5):620-30. PubMed ID: 12695351
[TBL] [Abstract][Full Text] [Related]
40. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Kim S; Dinchuk JE; Anthony MN; Orcutt T; Zoeckler ME; Sauer MB; Mosure KW; Vuppugalla R; Grace JE; Simmermacher J; Dulac HA; Pizzano J; Sinz M
Drug Metab Dispos; 2010 Jan; 38(1):16-24. PubMed ID: 19833845
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
