212 related articles for article (PubMed ID: 15265486)
1. Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
Kamal A; Srinivas O; Ramulu P; Ramesh G; Kumar PP; Kumar MS
Bioorg Med Chem; 2004 Aug; 12(16):4337-50. PubMed ID: 15265486
[TBL] [Abstract][Full Text] [Related]
2. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
Kamal A; Ramulu P; Srinivas O; Ramesh G
Bioorg Med Chem Lett; 2003 Nov; 13(22):3955-8. PubMed ID: 14592483
[TBL] [Abstract][Full Text] [Related]
4. Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity.
Kamal A; Ramu R; Khanna GB; Saxena AK; Shanmugavel M; Pandita RM
Bioorg Med Chem Lett; 2004 Oct; 14(19):4907-9. PubMed ID: 15341949
[TBL] [Abstract][Full Text] [Related]
5. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
Kamal A; Ramulu P; Srinivas O; Ramesh G; Kumar PP
Bioorg Med Chem Lett; 2004 Sep; 14(18):4791-4. PubMed ID: 15324909
[TBL] [Abstract][Full Text] [Related]
6. An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
Tiberghien AC; Evans DA; Kiakos K; Martin CR; Hartley JA; Thurston DE; Howard PW
Bioorg Med Chem Lett; 2008 Mar; 18(6):2073-7. PubMed ID: 18272367
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity.
Kamal A; Shankaraiah N; Devaiah V; Laxma Reddy K; Juvekar A; Sen S; Kurian N; Zingde S
Bioorg Med Chem Lett; 2008 Feb; 18(4):1468-73. PubMed ID: 18207392
[TBL] [Abstract][Full Text] [Related]
8. Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.
Kamal A; Shankaraiah N; Prabhakar S; Reddy ChR; Markandeya N; Reddy KL; Devaiah V
Bioorg Med Chem Lett; 2008 Apr; 18(7):2434-9. PubMed ID: 18325766
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
Kamal A; Devaiah V; Reddy KL; Kumar MS
Bioorg Med Chem; 2005 Mar; 13(6):2021-9. PubMed ID: 15727856
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
Antonow D; Kaliszczak M; Kang GD; Coffils M; Tiberghien AC; Cooper N; Barata T; Heidelberger S; James CH; Zloh M; Jenkins TC; Reszka AP; Neidle S; Guichard SM; Jodrell DI; Hartley JA; Howard PW; Thurston DE
J Med Chem; 2010 Apr; 53(7):2927-41. PubMed ID: 20218628
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity.
Kamal A; Ramesh G; Srinivas O; Ramulu P; Laxman N; Rehana T; Deepak M; Achary MS; Nagarajaram HA
Bioorg Med Chem; 2004 Oct; 12(20):5427-36. PubMed ID: 15388169
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
Gregson SJ; Howard PW; Thurston DE
Bioorg Med Chem Lett; 2003 Jul; 13(14):2277-80. PubMed ID: 12824017
[TBL] [Abstract][Full Text] [Related]
13. 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
Kamal A; Khan MN; Reddy KS; Ahmed SK; Kumar MS; Juvekar A; Sen S; Zingde S
Bioorg Med Chem Lett; 2007 Oct; 17(19):5345-8. PubMed ID: 17723301
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
Kamal A; Khan MN; Srikanth YV; Reddy KS; Juvekar A; Sen S; Kurian N; Zingde S
Bioorg Med Chem; 2008 Aug; 16(16):7804-10. PubMed ID: 18657979
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.
Masterson LA; Croker SJ; Jenkins TC; Howard PW; Thurston DE
Bioorg Med Chem Lett; 2004 Feb; 14(4):901-4. PubMed ID: 15012990
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents.
Wang JJ; Shen YK; Hu WP; Hsieh MC; Lin FL; Hsu MK; Hsu MH
J Med Chem; 2006 Feb; 49(4):1442-9. PubMed ID: 16480280
[TBL] [Abstract][Full Text] [Related]
17. Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential.
Kamal A; Rajender ; Reddy DR; Reddy MK; Balakishan G; Shaik TB; Chourasia M; Sastry GN
Bioorg Med Chem; 2009 Feb; 17(4):1557-72. PubMed ID: 19168361
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)--polymade conjugates and 2,2'-PBD dimers.
Reddy BS; Damayanthi Y; Reddy BS; Lown JW
Anticancer Drug Des; 2000 Jun; 15(3):225-38. PubMed ID: 11049090
[TBL] [Abstract][Full Text] [Related]
19. Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
Tiberghien AC; Hagan D; Howard PW; Thurston DE
Bioorg Med Chem Lett; 2004 Oct; 14(20):5041-4. PubMed ID: 15380195
[TBL] [Abstract][Full Text] [Related]
20. A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.
Chen Z; Gregson SJ; Howard PW; Thurston DE
Bioorg Med Chem Lett; 2004 Mar; 14(6):1547-9. PubMed ID: 15006400
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]