BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

282 related articles for article (PubMed ID: 15266024)

  • 1. Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.
    Sasaki K; Makita N; Sunami A; Sakurada H; Shirai N; Yokoi H; Kimura A; Tohse N; Hiraoka M; Kitabatake A
    Mol Pharmacol; 2004 Aug; 66(2):330-6. PubMed ID: 15266024
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.
    Tsang SY; Tsushima RG; Tomaselli GF; Li RA; Backx PH
    Mol Pharmacol; 2005 Feb; 67(2):424-34. PubMed ID: 15659774
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.
    Qu Y; Rogers J; Tanada T; Scheuer T; Catterall WA
    Proc Natl Acad Sci U S A; 1995 Dec; 92(25):11839-43. PubMed ID: 8524860
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of temperature and mexiletine on the F1473S Na+ channel mutation causing paramyotonia congenita.
    Fleischhauer R; Mitrovic N; Deymeer F; Lehmann-Horn F; Lerche H
    Pflugers Arch; 1998 Oct; 436(5):757-65. PubMed ID: 9716710
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation.
    Aoike F; Takahashi MP; Sakoda S
    Eur J Pharmacol; 2006 Feb; 532(1-2):24-31. PubMed ID: 16473348
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Sodium channel selectivity filter regulates antiarrhythmic drug binding.
    Sunami A; Dudley SC; Fozzard HA
    Proc Natl Acad Sci U S A; 1997 Dec; 94(25):14126-31. PubMed ID: 9391164
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [New aspects of the molecular effect of anti-arrhythmia agents].
    Honerjäger P
    Herz; 1990 Apr; 15(2):70-8. PubMed ID: 2160907
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
    Wang Y; Mi J; Lu K; Lu Y; Wang K
    PLoS One; 2015; 10(6):e0128653. PubMed ID: 26068619
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
    Sunami A; Glaaser IW; Fozzard HA
    Mol Pharmacol; 2001 Apr; 59(4):684-91. PubMed ID: 11259611
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.
    Wang GK; Russell C; Wang SY
    J Physiol; 2004 Feb; 554(Pt 3):621-33. PubMed ID: 14608007
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels.
    De Luca A; Natuzzi F; Desaphy JF; Loni G; Lentini G; Franchini C; Tortorella V; Camerino DC
    Mol Pharmacol; 2000 Feb; 57(2):268-77. PubMed ID: 10648636
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel alpha subunit in rat cardiac muscle.
    Duff HJ; Offord J; West J; Catterall WA
    Mol Pharmacol; 1992 Oct; 42(4):570-4. PubMed ID: 1331749
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
    Sunami A; Glaaser IW; Fozzard HA
    Proc Natl Acad Sci U S A; 2000 Feb; 97(5):2326-31. PubMed ID: 10681444
    [TBL] [Abstract][Full Text] [Related]  

  • 14. [The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].
    Sasaki K
    Hokkaido Igaku Zasshi; 2004 Nov; 79(6):747-54. PubMed ID: 15675305
    [No Abstract]   [Full Text] [Related]  

  • 15. Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
    Sheets MF; Hanck DA
    J Physiol; 2007 Jul; 582(Pt 1):317-34. PubMed ID: 17510181
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.
    Choi JS; Zhang L; Dib-Hajj SD; Han C; Tyrrell L; Lin Z; Wang X; Yang Y; Waxman SG
    Exp Neurol; 2009 Apr; 216(2):383-9. PubMed ID: 19162012
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.
    Sandtner W; Szendroedi J; Zarrabi T; Zebedin E; Hilber K; Glaaser I; Fozzard HA; Dudley SC; Todt H
    Mol Pharmacol; 2004 Sep; 66(3):648-57. PubMed ID: 15322257
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential interaction of R-mexiletine with the local anesthetic receptor site on brain and heart sodium channel alpha-subunits.
    Weiser T; Qu Y; Catterall WA; Scheuer T
    Mol Pharmacol; 1999 Dec; 56(6):1238-44. PubMed ID: 10570051
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties.
    Amin AS; Verkerk AO; Bhuiyan ZA; Wilde AA; Tan HL
    Acta Physiol Scand; 2005 Dec; 185(4):291-301. PubMed ID: 16266370
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Preferential block of late sodium current in the LQT3 DeltaKPQ mutant by the class I(C) antiarrhythmic flecainide.
    Nagatomo T; January CT; Makielski JC
    Mol Pharmacol; 2000 Jan; 57(1):101-7. PubMed ID: 10617684
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.