These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum. Chun KT; Bar-Nun S; Simoni RD J Biol Chem; 1990 Dec; 265(35):22004-10. PubMed ID: 2254343 [TBL] [Abstract][Full Text] [Related]
3. Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. Roitelman J; Bar-Nun S; Inoue S; Simoni RD J Biol Chem; 1991 Aug; 266(24):16085-91. PubMed ID: 1908464 [TBL] [Abstract][Full Text] [Related]
4. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. Keller RK; Zhao Z; Chambers C; Ness GC Arch Biochem Biophys; 1996 Apr; 328(2):324-30. PubMed ID: 8645011 [TBL] [Abstract][Full Text] [Related]
6. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Flint OP; Masters BA; Gregg RE; Durham SK Toxicol Appl Pharmacol; 1997 Jul; 145(1):91-8. PubMed ID: 9221828 [TBL] [Abstract][Full Text] [Related]
7. Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. Peffley DM; Gayen AK Arch Biochem Biophys; 1997 Jan; 337(2):251-60. PubMed ID: 9016820 [TBL] [Abstract][Full Text] [Related]
8. Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase. Cohen LH; van Vliet A; Roodenburg L; Jansen LM; Griffioen M Biochem Pharmacol; 1993 Jun; 45(11):2203-8. PubMed ID: 8517861 [TBL] [Abstract][Full Text] [Related]
9. Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. Meigs TE; Simoni RD Arch Biochem Biophys; 1997 Sep; 345(1):1-9. PubMed ID: 9281305 [TBL] [Abstract][Full Text] [Related]
10. Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase. Mosley ST; Brown MS; Anderson RG; Goldstein JL J Biol Chem; 1983 Nov; 258(22):13875-81. PubMed ID: 6643457 [TBL] [Abstract][Full Text] [Related]
11. Molecular dissection of the role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Kumagai H; Chun KT; Simoni RD J Biol Chem; 1995 Aug; 270(32):19107-13. PubMed ID: 7642576 [TBL] [Abstract][Full Text] [Related]
12. Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. Ness GC; Zhao Z; Keller RK Arch Biochem Biophys; 1994 Jun; 311(2):277-85. PubMed ID: 7911291 [TBL] [Abstract][Full Text] [Related]
13. Abnormal regulation of low density lipoprotein-sensitive events in a cholesterol transport mutant. Dahl NK; Gutheil WG; Liscum L J Biol Chem; 1993 Aug; 268(23):16979-86. PubMed ID: 8349588 [TBL] [Abstract][Full Text] [Related]
14. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and lipid metabolism in a concanavalin A-resistant Chinese hamster ovary cell line. Borgford TJ; Hurta RA; Tough DF; Burton DN Arch Biochem Biophys; 1986 Feb; 244(2):502-16. PubMed ID: 3947077 [TBL] [Abstract][Full Text] [Related]
15. Regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in permeabilized cells. Meigs TE; Simoni RD J Biol Chem; 1992 Jul; 267(19):13547-52. PubMed ID: 1618856 [TBL] [Abstract][Full Text] [Related]
16. Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity. Panini SR; Schnitzer-Polokoff R; Spencer TA; Sinensky M J Biol Chem; 1989 Jul; 264(19):11044-52. PubMed ID: 2567731 [TBL] [Abstract][Full Text] [Related]
17. Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. Giron MD; Havel CM; Watson JA Proc Natl Acad Sci U S A; 1994 Jul; 91(14):6398-402. PubMed ID: 8022795 [TBL] [Abstract][Full Text] [Related]
18. Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Ryan J; Hardeman EC; Endo A; Simoni RD J Biol Chem; 1981 Jul; 256(13):6762-8. PubMed ID: 7240242 [TBL] [Abstract][Full Text] [Related]
19. Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. Hidaka Y; Hotta H; Nagata Y; Iwasawa Y; Horie M; Kamei T J Biol Chem; 1991 Jul; 266(20):13171-7. PubMed ID: 1649182 [TBL] [Abstract][Full Text] [Related]
20. Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. Roitelman J; Simoni RD J Biol Chem; 1992 Dec; 267(35):25264-73. PubMed ID: 1460026 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]