BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

606 related articles for article (PubMed ID: 15274632)

  • 1. Purification and characterization of the human gamma-secretase complex.
    Fraering PC; Ye W; Strub JM; Dolios G; LaVoie MJ; Ostaszewski BL; van Dorsselaer A; Wang R; Selkoe DJ; Wolfe MS
    Biochemistry; 2004 Aug; 43(30):9774-89. PubMed ID: 15274632
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
    Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
    Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
    J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
    [TBL] [Abstract][Full Text] [Related]  

  • 4. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
    Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
    J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
    Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
    Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.
    Massey LK; Mah AL; Monteiro MJ
    Biochem J; 2005 Nov; 391(Pt 3):513-25. PubMed ID: 15975090
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
    Winkler E; Hobson S; Fukumori A; Dümpelfeld B; Luebbers T; Baumann K; Haass C; Hopf C; Steiner H
    Biochemistry; 2009 Feb; 48(6):1183-97. PubMed ID: 19159235
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides.
    Zhang L; Song L; Terracina G; Liu Y; Pramanik B; Parker E
    Biochemistry; 2001 Apr; 40(16):5049-55. PubMed ID: 11305921
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Gamma-secretase complex assembly within the early secretory pathway.
    Capell A; Beher D; Prokop S; Steiner H; Kaether C; Shearman MS; Haass C
    J Biol Chem; 2005 Feb; 280(8):6471-8. PubMed ID: 15591316
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reconstitution of gamma-secretase activity.
    Edbauer D; Winkler E; Regula JT; Pesold B; Steiner H; Haass C
    Nat Cell Biol; 2003 May; 5(5):486-8. PubMed ID: 12679784
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.
    Kim H; Ki H; Park HS; Kim K
    J Biol Chem; 2005 Jun; 280(23):22462-72. PubMed ID: 15797863
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 16. gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.
    Fraering PC; Ye W; LaVoie MJ; Ostaszewski BL; Selkoe DJ; Wolfe MS
    J Biol Chem; 2005 Dec; 280(51):41987-96. PubMed ID: 16236717
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
    Periz G; Fortini ME
    J Neurosci Res; 2004 Aug; 77(3):309-22. PubMed ID: 15248287
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
    Zhang L; Lee J; Song L; Sun X; Shen J; Terracina G; Parker EM
    Biochemistry; 2005 Mar; 44(11):4450-7. PubMed ID: 15766275
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
    Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
    J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
    LaVoie MJ; Fraering PC; Ostaszewski BL; Ye W; Kimberly WT; Wolfe MS; Selkoe DJ
    J Biol Chem; 2003 Sep; 278(39):37213-22. PubMed ID: 12857757
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 31.