BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

453 related articles for article (PubMed ID: 15277684)

  • 1. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
    Hazuda DJ; Anthony NJ; Gomez RP; Jolly SM; Wai JS; Zhuang L; Fisher TE; Embrey M; Guare JP; Egbertson MS; Vacca JP; Huff JR; Felock PJ; Witmer MV; Stillmock KA; Danovich R; Grobler J; Miller MD; Espeseth AS; Jin L; Chen IW; Lin JH; Kassahun K; Ellis JD; Wong BK; Xu W; Pearson PG; Schleif WA; Cortese R; Emini E; Summa V; Holloway MK; Young SD
    Proc Natl Acad Sci U S A; 2004 Aug; 101(31):11233-8. PubMed ID: 15277684
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
    Zeng LF; Wang Y; Kazemi R; Xu S; Xu ZL; Sanchez TW; Yang LM; Debnath B; Odde S; Xie H; Zheng YT; Ding J; Neamati N; Long YQ
    J Med Chem; 2012 Nov; 55(22):9492-509. PubMed ID: 23098137
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.
    Kehlenbeck S; Betz U; Birkmann A; Fast B; Göller AH; Henninger K; Lowinger T; Marrero D; Paessens A; Paulsen D; Pevzner V; Schohe-Loop R; Tsujishita H; Welker R; Kreuter J; Rübsamen-Waigmann H; Dittmer F
    J Virol; 2006 Jul; 80(14):6883-94. PubMed ID: 16809294
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selection and analysis of HIV-1 integrase strand transfer inhibitor resistant mutant viruses.
    Witmer M; Danovich R
    Methods; 2009 Apr; 47(4):277-82. PubMed ID: 19286458
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
    Melamed JY; Egbertson MS; Varga S; Vacca JP; Moyer G; Gabryelski L; Felock PJ; Stillmock KA; Witmer MV; Schleif W; Hazuda DJ; Leonard Y; Jin L; Ellis JD; Young SD
    Bioorg Med Chem Lett; 2008 Oct; 18(19):5307-10. PubMed ID: 18774711
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
    Garvey EP; Johns BA; Gartland MJ; Foster SA; Miller WH; Ferris RG; Hazen RJ; Underwood MR; Boros EE; Thompson JB; Weatherhead JG; Koble CS; Allen SH; Schaller LT; Sherrill RG; Yoshinaga T; Kobayashi M; Wakasa-Morimoto C; Miki S; Nakahara K; Noshi T; Sato A; Fujiwara T
    Antimicrob Agents Chemother; 2008 Mar; 52(3):901-8. PubMed ID: 18160521
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
    Embrey MW; Wai JS; Funk TW; Homnick CF; Perlow DS; Young SD; Vacca JP; Hazuda DJ; Felock PJ; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Jin L; Chen IW; Ellis JD; Wong BK; Lin JH; Leonard YM; Tsou NN; Zhuang L
    Bioorg Med Chem Lett; 2005 Oct; 15(20):4550-4. PubMed ID: 16102965
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization and structural analysis of HIV-1 integrase conservation.
    Ceccherini-Silberstein F; Malet I; D'Arrigo R; Antinori A; Marcelin AG; Perno CF
    AIDS Rev; 2009; 11(1):17-29. PubMed ID: 19290031
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance.
    Zahm JA; Bera S; Pandey KK; Vora A; Stillmock K; Hazuda D; Grandgenett DP
    Antimicrob Agents Chemother; 2008 Sep; 52(9):3358-68. PubMed ID: 18591263
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.
    Hazuda DJ; Young SD; Guare JP; Anthony NJ; Gomez RP; Wai JS; Vacca JP; Handt L; Motzel SL; Klein HJ; Dornadula G; Danovich RM; Witmer MV; Wilson KA; Tussey L; Schleif WA; Gabryelski LS; Jin L; Miller MD; Casimiro DR; Emini EA; Shiver JW
    Science; 2004 Jul; 305(5683):528-32. PubMed ID: 15247437
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
    Zhuang L; Wai JS; Embrey MW; Fisher TE; Egbertson MS; Payne LS; Guare JP; Vacca JP; Hazuda DJ; Felock PJ; Wolfe AL; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Leonard YM; Lynch JJ; Michelson SR; Young SD
    J Med Chem; 2003 Feb; 46(4):453-6. PubMed ID: 12570367
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.
    Hombrouck A; Voet A; Van Remoortel B; Desadeleer C; De Maeyer M; Debyser Z; Witvrouw M
    Antimicrob Agents Chemother; 2008 Jun; 52(6):2069-78. PubMed ID: 18378713
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HIV type 1 integrase inhibitors: from basic research to clinical implications.
    Jegede O; Babu J; Di Santo R; McColl DJ; Weber J; Quiñones-Mateu M
    AIDS Rev; 2008; 10(3):172-89. PubMed ID: 18820719
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
    Guare JP; Wai JS; Gomez RP; Anthony NJ; Jolly SM; Cortes AR; Vacca JP; Felock PJ; Stillmock KA; Schleif WA; Moyer G; Gabryelski LJ; Jin L; Chen IW; Hazuda DJ; Young SD
    Bioorg Med Chem Lett; 2006 Jun; 16(11):2900-4. PubMed ID: 16554152
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
    Boros EE; Edwards CE; Foster SA; Fuji M; Fujiwara T; Garvey EP; Golden PL; Hazen RJ; Jeffrey JL; Johns BA; Kawasuji T; Kiyama R; Koble CS; Kurose N; Miller WH; Mote AL; Murai H; Sato A; Thompson JB; Woodward MC; Yoshinaga T
    J Med Chem; 2009 May; 52(9):2754-61. PubMed ID: 19374386
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Resistance to HIV-1 integrase inhibitors: A structural perspective.
    Mouscadet JF; Delelis O; Marcelin AG; Tchertanov L
    Drug Resist Updat; 2010; 13(4-5):139-50. PubMed ID: 20570551
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.
    Ma K; Wang P; Fu W; Wan X; Zhou L; Chu Y; Ye D
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6724-7. PubMed ID: 21996518
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.
    Hazuda DJ; Felock P; Witmer M; Wolfe A; Stillmock K; Grobler JA; Espeseth A; Gabryelski L; Schleif W; Blau C; Miller MD
    Science; 2000 Jan; 287(5453):646-50. PubMed ID: 10649997
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
    Kobayashi M; Yoshinaga T; Seki T; Wakasa-Morimoto C; Brown KW; Ferris R; Foster SA; Hazen RJ; Miki S; Suyama-Kagitani A; Kawauchi-Miki S; Taishi T; Kawasuji T; Johns BA; Underwood MR; Garvey EP; Sato A; Fujiwara T
    Antimicrob Agents Chemother; 2011 Feb; 55(2):813-21. PubMed ID: 21115794
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Human immunodeficiency virus type 1 (HIV-1) integrase: resistance to diketo acid integrase inhibitors impairs HIV-1 replication and integration and confers cross-resistance to L-chicoric acid.
    Lee DJ; Robinson WE
    J Virol; 2004 Jun; 78(11):5835-47. PubMed ID: 15140981
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.