206 related articles for article (PubMed ID: 15286715)
1. The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate.
Caraglia M; D'Alessandro AM; Marra M; Giuberti G; Vitale G; Viscomi C; Colao A; Prete SD; Tagliaferri P; Tassone P; Budillon A; Venuta S; Abbruzzese A
Oncogene; 2004 Sep; 23(41):6900-13. PubMed ID: 15286715
[TBL] [Abstract][Full Text] [Related]
2. R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation.
Caraglia M; Marra M; Leonetti C; Meo G; D'Alessandro AM; Baldi A; Santini D; Tonini G; Bertieri R; Zupi G; Budillon A; Abbruzzese A
J Cell Physiol; 2007 May; 211(2):533-43. PubMed ID: 17192846
[TBL] [Abstract][Full Text] [Related]
3. The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.
Caraglia M; Marra M; Viscomi C; D'Alessandro AM; Budillon A; Meo G; Arra C; Barbieri A; Rapp UR; Baldi A; Tassone P; Venuta S; Abbruzzese A; Tagliaferri P
Int J Cancer; 2007 Nov; 121(10):2317-30. PubMed ID: 17657738
[TBL] [Abstract][Full Text] [Related]
4. Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells.
Smalley KS; Eisen TG
Int J Cancer; 2003 Jun; 105(2):165-75. PubMed ID: 12673674
[TBL] [Abstract][Full Text] [Related]
5. Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells.
Le Gouill S; Pellat-Deceunynck C; Harousseau JL; Rapp MJ; Robillard N; Bataille R; Amiot M
Leukemia; 2002 Sep; 16(9):1664-7. PubMed ID: 12200678
[TBL] [Abstract][Full Text] [Related]
6. Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.
Kelland LR; Smith V; Valenti M; Patterson L; Clarke PA; Detre S; End D; Howes AJ; Dowsett M; Workman P; Johnston SR
Clin Cancer Res; 2001 Nov; 7(11):3544-50. PubMed ID: 11705875
[TBL] [Abstract][Full Text] [Related]
7. Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone.
Lau CP; Huang L; Tsui SK; Ng PK; Leung PY; Kumta SM
J Orthop Res; 2011 Mar; 29(3):403-13. PubMed ID: 20886653
[TBL] [Abstract][Full Text] [Related]
8. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Lobell RB; Omer CA; Abrams MT; Bhimnathwala HG; Brucker MJ; Buser CA; Davide JP; deSolms SJ; Dinsmore CJ; Ellis-Hutchings MS; Kral AM; Liu D; Lumma WC; Machotka SV; Rands E; Williams TM; Graham SL; Hartman GD; Oliff AI; Heimbrook DC; Kohl NE
Cancer Res; 2001 Dec; 61(24):8758-68. PubMed ID: 11751396
[TBL] [Abstract][Full Text] [Related]
9. Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.
Venkatasubbarao K; Choudary A; Freeman JW
Cancer Res; 2005 Apr; 65(7):2861-71. PubMed ID: 15805288
[TBL] [Abstract][Full Text] [Related]
10. Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.
Feldkamp MM; Lau N; Guha A
Oncogene; 1999 Dec; 18(52):7514-26. PubMed ID: 10602510
[TBL] [Abstract][Full Text] [Related]
11. Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells.
Lee HY; Moon H; Chun KH; Chang YS; Hassan K; Ji L; Lotan R; Khuri FR; Hong WK
J Natl Cancer Inst; 2004 Oct; 96(20):1536-48. PubMed ID: 15494604
[TBL] [Abstract][Full Text] [Related]
12. Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor r115777 in human epithelial cancer cells.
Caraglia M; Giuberti G; Marra M; Di Gennaro E; Facchini G; Caponigro F; Iaffaioli R; Budillon A; Abbruzzese A
Front Biosci; 2005 Sep; 10():2566-75. PubMed ID: 15970518
[TBL] [Abstract][Full Text] [Related]
13. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
End DW; Smets G; Todd AV; Applegate TL; Fuery CJ; Angibaud P; Venet M; Sanz G; Poignet H; Skrzat S; Devine A; Wouters W; Bowden C
Cancer Res; 2001 Jan; 61(1):131-7. PubMed ID: 11196150
[TBL] [Abstract][Full Text] [Related]
14. Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro.
Tassone P; Tagliaferri P; Viscomi C; Palmieri C; Caraglia M; D'Alessandro A; Galea E; Goel A; Abbruzzese A; Boland CR; Venuta S
Br J Cancer; 2003 Jun; 88(12):1971-8. PubMed ID: 12799645
[TBL] [Abstract][Full Text] [Related]
15. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
Brassard DL; English JM; Malkowski M; Kirschmeier P; Nagabhushan TL; Bishop WR
Exp Cell Res; 2002 Feb; 273(2):138-46. PubMed ID: 11822869
[TBL] [Abstract][Full Text] [Related]
16. Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
Smith V; Rowlands MG; Barrie E; Workman P; Kelland LR
Clin Cancer Res; 2002 Jun; 8(6):2002-9. PubMed ID: 12060646
[TBL] [Abstract][Full Text] [Related]
17. EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-alpha-mediated apoptosis in epidermoid cancer cells.
Caraglia M; Tagliaferri P; Marra M; Giuberti G; Budillon A; Gennaro ED; Pepe S; Vitale G; Improta S; Tassone P; Venuta S; Bianco AR; Abbruzzese A
Cell Death Differ; 2003 Feb; 10(2):218-29. PubMed ID: 12700650
[TBL] [Abstract][Full Text] [Related]
18. Zoledronic acid produces antitumor effects on mesothelioma through apoptosis and S-phase arrest in p53-independent and Ras prenylation-independent manners.
Okamoto S; Kawamura K; Li Q; Yamanaka M; Yang S; Fukamachi T; Tada Y; Tatsumi K; Shimada H; Hiroshima K; Kobayashi H; Tagawa M
J Thorac Oncol; 2012 May; 7(5):873-82. PubMed ID: 22481236
[TBL] [Abstract][Full Text] [Related]
19. Investigation of the effect of the farnesyl protein transferase inhibitor R115777 on isoprenylation and intracellular signalling by the prostacyclin receptor.
O'Meara SJ; Kinsella BT
Br J Pharmacol; 2004 Sep; 143(2):318-30. PubMed ID: 15339863
[TBL] [Abstract][Full Text] [Related]
20. Biomarkers of anticancer activity of R115777 (Tipifarnib, Zarnestra) in human breast cancer models in vitro.
Izbicka E; Campos D; Carrizales G; Patnaik A
Anticancer Res; 2005; 25(5):3215-23. PubMed ID: 16101130
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
