BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 15288810)

  • 1. Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process.
    Wei L; Lai Z; Gan X; Alliston KR; Zhong J; Epp JB; Tu J; Perera AB; Van Stipdonk M; Groutas WC
    Arch Biochem Biophys; 2004 Sep; 429(1):60-70. PubMed ID: 15288810
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives.
    Lai Z; Gan X; Wei L; Alliston KR; Yu H; Li YH; Groutas WC
    Arch Biochem Biophys; 2004 Sep; 429(2):191-7. PubMed ID: 15313222
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold.
    Groutas WC; Kuang R; Venkataraman R; Epp JB; Ruan S; Prakash O
    Biochemistry; 1997 Apr; 36(16):4739-50. PubMed ID: 9125494
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism-based isocoumarin inhibitors for serine proteases: use of active site structure and substrate specificity in inhibitor design.
    Powers JC; Kam CM; Narasimhan L; Oleksyszyn J; Hernandez MA; Ueda T
    J Cell Biochem; 1989 Jan; 39(1):33-46. PubMed ID: 2654146
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase.
    Wong T; Groutas CS; Mohan S; Lai Z; Alliston KR; Vu N; Schechter NM; Groutas WC
    Arch Biochem Biophys; 2005 Apr; 436(1):1-7. PubMed ID: 15752703
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase.
    Regan J; McGarry D; Bruno J; Green D; Newman J; Hsu CY; Kline J; Barton J; Travis J; Choi YM; Volz F; Pauls H; Harrison R; Zilberstein A; Ben-Sasson SA; Chang M
    J Med Chem; 1997 Oct; 40(21):3408-22. PubMed ID: 9341916
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Binding pockets on the surface of human leukocyte elastase and human leukocyte cathepsin G. Implications to the design of inhibitors derived from human C-reactive protein.
    Yavin EJ; Eisenstein M; Fridkin M
    Biomed Pept Proteins Nucleic Acids; 1996-1997; 2(3):71-8. PubMed ID: 9575343
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase.
    Buynak JD; Rao AS; Ford GP; Carver C; Adam G; Geng B; Bachmann B; Shobassy S; Lackey S
    J Med Chem; 1997 Oct; 40(21):3423-33. PubMed ID: 9341917
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors.
    Guy L; Vidal J; Collet A; Amour A; Reboud-Ravaux M
    J Med Chem; 1998 Nov; 41(24):4833-43. PubMed ID: 9822552
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams.
    Tsang WY; Ahmed N; Harding LP; Hemming K; Laws AP; Page MI
    J Am Chem Soc; 2005 Jun; 127(25):8946-7. PubMed ID: 15969560
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase.
    Gütschow M; Neumann U
    J Med Chem; 1998 May; 41(10):1729-40. PubMed ID: 9572899
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations.
    Estácio SG; Moreira R; Guedes RC
    J Chem Inf Model; 2011 Jul; 51(7):1690-702. PubMed ID: 21639142
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases.
    Groutas WC; Epp JB; Kuang R; Ruan S; Chong LS; Venkataraman R; Tu J; He S; Yu H; Fu Q; Li YH; Truong TM; Vu NT
    Arch Biochem Biophys; 2001 Jan; 385(1):162-9. PubMed ID: 11361013
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.
    Moreira R; Santana AB; Iley J; Neres J; Douglas KT; Horton PN; Hursthouse MB
    J Med Chem; 2005 Jul; 48(15):4861-70. PubMed ID: 16033266
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The electrostatic driving force for nucleophilic catalysis in L-arginine deiminase: a combined experimental and theoretical study.
    Li L; Li Z; Wang C; Xu D; Mariano PS; Guo H; Dunaway-Mariano D
    Biochemistry; 2008 Apr; 47(16):4721-32. PubMed ID: 18366187
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Theoretical analysis of peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase: Insight into the mechanism of inhibition and the application of QM/MM calculations in structure-based drug design.
    Gleeson MP; Hillier IH; Burton NA
    Org Biomol Chem; 2004 Aug; 2(16):2275-80. PubMed ID: 15305206
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design of amino acid sulfonamides as transition-state analogue inhibitors of arginase.
    Cama E; Shin H; Christianson DW
    J Am Chem Soc; 2003 Oct; 125(43):13052-7. PubMed ID: 14570477
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold.
    Zhong J; Gan X; Alliston KR; Groutas WC
    Bioorg Med Chem; 2004 Feb; 12(3):589-93. PubMed ID: 14738969
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interaction of human leukocyte elastase with plasma fibronectin and its inhibition by soybean Bowman-Birk protease inhibitor.
    Larionova NI; Balabushevitch NG; Zhatikov PA
    Biochemistry (Mosc); 1998 Sep; 63(9):1078-82. PubMed ID: 9795279
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Potential protease inhibitors based on a functionalized cyclic sulfamide scaffold.
    Zhong J; Gan X; Alliston KR; Lai Z; Yu H; Groutas CS; Wong T; Groutas WC
    J Comb Chem; 2004; 6(4):556-63. PubMed ID: 15244417
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.