259 related articles for article (PubMed ID: 15291757)
1. Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase.
Thomas JL; Duax WL; Addlagatta A; Scaccia LA; Frizzell KA; Carloni SB
J Mol Endocrinol; 2004 Aug; 33(1):253-61. PubMed ID: 15291757
[TBL] [Abstract][Full Text] [Related]
2. Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity.
Thomas JL; Mason JI; Brandt S; Spencer BR; Norris W
J Biol Chem; 2002 Nov; 277(45):42795-801. PubMed ID: 12205101
[TBL] [Abstract][Full Text] [Related]
3. Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.
Thomas JL; Boswell EL; Scaccia LA; Pletnev V; Umland TC
J Biol Chem; 2005 Jun; 280(22):21321-8. PubMed ID: 15797861
[TBL] [Abstract][Full Text] [Related]
4. Structure/function aspects of human 3beta-hydroxysteroid dehydrogenase.
Thomas JL; Duax WL; Addlagatta A; Kacsoh B; Brandt SE; Norris WB
Mol Cell Endocrinol; 2004 Feb; 215(1-2):73-82. PubMed ID: 15026177
[TBL] [Abstract][Full Text] [Related]
5. The engineered, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase: purification, characterization and crystallization.
Thomas JL; Mason JI; Blanco G; Veisaga ML
J Mol Endocrinol; 2001 Aug; 27(1):77-83. PubMed ID: 11463578
[TBL] [Abstract][Full Text] [Related]
6. Site-directed mutagenesis identifies amino acid residues associated with the dehydrogenase and isomerase activities of human type I (placental) 3beta-hydroxysteroid dehydrogenase/isomerase.
Thomas JL; Evans BW; Blanco G; Mercer RW; Mason JI; Adler S; Nash WE; Isenberg KE; Strickler RC
J Steroid Biochem Mol Biol; 1998 Sep; 66(5-6):327-34. PubMed ID: 9749838
[TBL] [Abstract][Full Text] [Related]
7. Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.
Thomas JL; Mack VL; Glow JA; Moshkelani D; Terrell JR; Bucholtz KM
J Steroid Biochem Mol Biol; 2008 Jul; 111(1-2):66-73. PubMed ID: 18524572
[TBL] [Abstract][Full Text] [Related]
8. Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase.
Thomas JL; Duax WL; Addlagatta A; Brandt S; Fuller RR; Norris W
J Biol Chem; 2003 Sep; 278(37):35483-90. PubMed ID: 12832414
[TBL] [Abstract][Full Text] [Related]
9. Structure/function of human type 1 3beta-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization.
Thomas JL; Huether R; Mack VL; Scaccia LA; Stoner RC; Duax WL
J Steroid Biochem Mol Biol; 2007 Oct; 107(1-2):80-7. PubMed ID: 17624763
[TBL] [Abstract][Full Text] [Related]
10. Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1.
Pletnev VZ; Thomas JL; Rhaney FL; Holt LS; Scaccia LA; Umland TC; Duax WL
J Steroid Biochem Mol Biol; 2006 Sep; 101(1):50-60. PubMed ID: 16889958
[TBL] [Abstract][Full Text] [Related]
11. Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues.
Labrie F; Simard J; Luu-The V; Bélanger A; Pelletier G
J Steroid Biochem Mol Biol; 1992 Dec; 43(8):805-26. PubMed ID: 22217825
[TBL] [Abstract][Full Text] [Related]
12. Creation of a fully active, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase by the deletion of a membrane-spanning domain.
Thomas JL; Evans BW; Blanco G; Mason JI; Strickler RC
J Mol Endocrinol; 1999 Oct; 23(2):231-9. PubMed ID: 10514560
[TBL] [Abstract][Full Text] [Related]
13. The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis.
Thomas JL; Mack VL; Sun J; Terrell JR; Bucholtz KM
J Steroid Biochem Mol Biol; 2010 Jun; 120(4-5):192-9. PubMed ID: 20420909
[TBL] [Abstract][Full Text] [Related]
14. Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni.
Hwang CC; Chang YH; Hsu CN; Hsu HH; Li CW; Pon HI
J Biol Chem; 2005 Feb; 280(5):3522-8. PubMed ID: 15572373
[TBL] [Abstract][Full Text] [Related]
15. The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.
Thomas JL; Umland TC; Scaccia LA; Boswell EL; Kacsoh B
Endocr Res; 2004 Nov; 30(4):935-41. PubMed ID: 15666848
[TBL] [Abstract][Full Text] [Related]
16. Nonsalt-losing male pseudohermaphroditism due to the novel homozygous N100S mutation in the type II 3 beta-hydroxysteroid dehydrogenase gene.
Mébarki F; Sanchez R; Rhéaume E; Laflamme N; Simard J; Forest MG; Bey-Omar F; David M; Labrie F; Morel Y
J Clin Endocrinol Metab; 1995 Jul; 80(7):2127-34. PubMed ID: 7608265
[TBL] [Abstract][Full Text] [Related]
17. Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases.
Schlegel BP; Jez JM; Penning TM
Biochemistry; 1998 Mar; 37(10):3538-48. PubMed ID: 9521675
[TBL] [Abstract][Full Text] [Related]
18. Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.
Pawlowski JE; Penning TM
J Biol Chem; 1994 May; 269(18):13502-10. PubMed ID: 8175784
[TBL] [Abstract][Full Text] [Related]
19. Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine.
Schlegel BP; Ratnam K; Penning TM
Biochemistry; 1998 Aug; 37(31):11003-11. PubMed ID: 9692994
[TBL] [Abstract][Full Text] [Related]
20. Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase.
Jez JM; Penning TM
Biochemistry; 1998 Jul; 37(27):9695-703. PubMed ID: 9657682
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
