BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

144 related articles for article (PubMed ID: 15292251)

  • 1. The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling.
    Lievens PM; Mutinelli C; Baynes D; Liboi E
    J Biol Chem; 2004 Oct; 279(41):43254-60. PubMed ID: 15292251
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum.
    Lievens PM; Liboi E
    J Biol Chem; 2003 May; 278(19):17344-9. PubMed ID: 12624096
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.
    Hart KC; Robertson SC; Donoghue DJ
    Mol Biol Cell; 2001 Apr; 12(4):931-42. PubMed ID: 11294897
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.
    Hart KC; Robertson SC; Kanemitsu MY; Meyer AN; Tynan JA; Donoghue DJ
    Oncogene; 2000 Jul; 19(29):3309-20. PubMed ID: 10918587
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation.
    Meyer AN; Gastwirt RF; Schlaepfer DD; Donoghue DJ
    J Biol Chem; 2004 Jul; 279(27):28450-7. PubMed ID: 15105428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction.
    Sandberg EM; VonDerLinden D; Ostrov DA; Sayeski PP
    Mol Cell Biochem; 2004 Oct; 265(1-2):161-9. PubMed ID: 15543946
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype.
    Bellus GA; Spector EB; Speiser PW; Weaver CA; Garber AT; Bryke CR; Israel J; Rosengren SS; Webster MK; Donoghue DJ; Francomano CA
    Am J Hum Genet; 2000 Dec; 67(6):1411-21. PubMed ID: 11055896
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1.
    Harada D; Yamanaka Y; Ueda K; Nishimura R; Morishima T; Seino Y; Tanaka H
    Bone; 2007 Aug; 41(2):273-81. PubMed ID: 17561467
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism.
    Su WC; Kitagawa M; Xue N; Xie B; Garofalo S; Cho J; Deng C; Horton WA; Fu XY
    Nature; 1997 Mar; 386(6622):288-92. PubMed ID: 9069288
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutant FGFR3 associated with SADDAN disease causes cytoskeleton disorganization through PLCĪ³1/Src-mediated paxillin hyperphosphorylation.
    Montone R; Romanelli MG; Baruzzi A; Ferrarini F; Liboi E; Lievens PM
    Int J Biochem Cell Biol; 2018 Feb; 95():17-26. PubMed ID: 29242050
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias.
    Legeai-Mallet L; Benoist-Lasselin C; Munnich A; Bonaventure J
    Bone; 2004 Jan; 34(1):26-36. PubMed ID: 14751560
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.
    Li C; Chen L; Iwata T; Kitagawa M; Fu XY; Deng CX
    Hum Mol Genet; 1999 Jan; 8(1):35-44. PubMed ID: 9887329
    [TBL] [Abstract][Full Text] [Related]  

  • 13. RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.
    Plaza Menacho I; Koster R; van der Sloot AM; Quax WJ; Osinga J; van der Sluis T; Hollema H; Burzynski GM; Gimm O; Buys CH; Eggen BJ; Hofstra RM
    Cancer Res; 2005 Mar; 65(5):1729-37. PubMed ID: 15753368
    [TBL] [Abstract][Full Text] [Related]  

  • 14. SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.
    Ali S; Nouhi Z; Chughtai N; Ali S
    J Biol Chem; 2003 Dec; 278(52):52021-31. PubMed ID: 14522994
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.
    Quelle FW; Thierfelder W; Witthuhn BA; Tang B; Cohen S; Ihle JN
    J Biol Chem; 1995 Sep; 270(35):20775-80. PubMed ID: 7657660
    [TBL] [Abstract][Full Text] [Related]  

  • 16. K644E/M FGFR3 mutants activate Erk1/2 from the endoplasmic reticulum through FRS2 alpha and PLC gamma-independent pathways.
    Lievens PM; Roncador A; Liboi E
    J Mol Biol; 2006 Mar; 357(3):783-92. PubMed ID: 16476447
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.
    Liang Q; Mohan RR; Chen L; Wilson SE
    Invest Ophthalmol Vis Sci; 1998 Jul; 39(8):1329-38. PubMed ID: 9660480
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
    Zhang Y; Turkson J; Carter-Su C; Smithgall T; Levitzki A; Kraker A; Krolewski JJ; Medveczky P; Jove R
    J Biol Chem; 2000 Aug; 275(32):24935-44. PubMed ID: 10823829
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.
    Murakami S; Balmes G; McKinney S; Zhang Z; Givol D; de Crombrugghe B
    Genes Dev; 2004 Feb; 18(3):290-305. PubMed ID: 14871928
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Suppression of severe achondroplasia with developmental delay and acanthosis nigricans by the p.Thr651Pro mutation.
    Manickam K; Donoghue DJ; Meyer AN; Snyder PJ; Prior TW
    Am J Med Genet A; 2014 Jan; 164A(1):243-50. PubMed ID: 24352917
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.