BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

804 related articles for article (PubMed ID: 15302861)

  • 1. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
    Stolze IP; Tian YM; Appelhoff RJ; Turley H; Wykoff CC; Gleadle JM; Ratcliffe PJ
    J Biol Chem; 2004 Oct; 279(41):42719-25. PubMed ID: 15302861
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
    Appelhoff RJ; Tian YM; Raval RR; Turley H; Harris AL; Pugh CW; Ratcliffe PJ; Gleadle JM
    J Biol Chem; 2004 Sep; 279(37):38458-65. PubMed ID: 15247232
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    Koivunen P; Hirsilä M; Günzler V; Kivirikko KI; Myllyharju J
    J Biol Chem; 2004 Mar; 279(11):9899-904. PubMed ID: 14701857
    [TBL] [Abstract][Full Text] [Related]  

  • 4. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
    Berra E; Benizri E; Ginouvès A; Volmat V; Roux D; Pouysségur J
    EMBO J; 2003 Aug; 22(16):4082-90. PubMed ID: 12912907
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
    Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.
    Martin F; Linden T; Katschinski DM; Oehme F; Flamme I; Mukhopadhyay CK; Eckhardt K; Tröger J; Barth S; Camenisch G; Wenger RH
    Blood; 2005 Jun; 105(12):4613-9. PubMed ID: 15741220
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.
    Dayan F; Roux D; Brahimi-Horn MC; Pouyssegur J; Mazure NM
    Cancer Res; 2006 Apr; 66(7):3688-98. PubMed ID: 16585195
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.
    Tarhonskaya H; Hardy AP; Howe EA; Loik ND; Kramer HB; McCullagh JS; Schofield CJ; Flashman E
    J Biol Chem; 2015 Aug; 290(32):19726-42. PubMed ID: 26112411
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
    Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ
    J Biol Chem; 2002 Jul; 277(29):26351-5. PubMed ID: 12042299
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.
    Chan MC; Ilott NE; Schödel J; Sims D; Tumber A; Lippl K; Mole DR; Pugh CW; Ratcliffe PJ; Ponting CP; Schofield CJ
    J Biol Chem; 2016 Sep; 291(39):20661-73. PubMed ID: 27502280
    [TBL] [Abstract][Full Text] [Related]  

  • 11. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.
    Lando D; Peet DJ; Gorman JJ; Whelan DA; Whitelaw ML; Bruick RK
    Genes Dev; 2002 Jun; 16(12):1466-71. PubMed ID: 12080085
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
    Wu Y; Li Z; McDonough MA; Schofield CJ; Zhang X
    J Med Chem; 2021 Jun; 64(11):7189-7209. PubMed ID: 34029087
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway.
    Dann CE; Bruick RK; Deisenhofer J
    Proc Natl Acad Sci U S A; 2002 Nov; 99(24):15351-6. PubMed ID: 12432100
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors.
    Dalgard CL; Lu H; Mohyeldin A; Verma A
    Biochem J; 2004 Jun; 380(Pt 2):419-24. PubMed ID: 14984367
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH).
    Flagg SC; Martin CB; Taabazuing CY; Holmes BE; Knapp MJ
    J Inorg Biochem; 2012 Aug; 113():25-30. PubMed ID: 22687491
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
    Hewitson KS; Schofield CJ; Ratcliffe PJ
    Methods Enzymol; 2007; 435():25-42. PubMed ID: 17998047
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.
    Aprelikova O; Chandramouli GV; Wood M; Vasselli JR; Riss J; Maranchie JK; Linehan WM; Barrett JC
    J Cell Biochem; 2004 Jun; 92(3):491-501. PubMed ID: 15156561
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selective inhibition of factor inhibiting hypoxia-inducible factor.
    McDonough MA; McNeill LA; Tilliet M; Papamicaël CA; Chen QY; Banerji B; Hewitson KS; Schofield CJ
    J Am Chem Soc; 2005 Jun; 127(21):7680-1. PubMed ID: 15913349
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HIF hydroxylation and cellular oxygen sensing.
    Metzen E; Ratcliffe PJ
    Biol Chem; 2004; 385(3-4):223-30. PubMed ID: 15134335
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.
    Martín-Puig S; Temes E; Olmos G; Jones DR; Aragonés J; Landázuri MO
    J Biol Chem; 2004 Mar; 279(10):9504-11. PubMed ID: 14681229
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 41.