201 related articles for article (PubMed ID: 15308640)
1. Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization.
Taylor LM; James A; Schuller CE; Brce J; Lock RB; Mackenzie KL
J Biol Chem; 2004 Oct; 279(42):43634-45. PubMed ID: 15308640
[TBL] [Abstract][Full Text] [Related]
2. Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.
MacKenzie KL; Franco S; May C; Sadelain M; Moore MA
Exp Cell Res; 2000 Sep; 259(2):336-50. PubMed ID: 10964501
[TBL] [Abstract][Full Text] [Related]
3. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.
Davis T; Singhrao SK; Wyllie FS; Haughton MF; Smith PJ; Wiltshire M; Wynford-Thomas D; Jones CJ; Faragher RG; Kipling D
J Cell Sci; 2003 Apr; 116(Pt 7):1349-57. PubMed ID: 12615976
[TBL] [Abstract][Full Text] [Related]
4. Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb.
Veitonmäki N; Fuxe J; Hultdin M; Roos G; Pettersson RF; Cao Y
FASEB J; 2003 Apr; 17(6):764-6. PubMed ID: 12586745
[TBL] [Abstract][Full Text] [Related]
5. Immortalization of normal human embryonic fibroblasts by introduction of either the human papillomavirus type 16 E6 or E7 gene alone.
Yamamoto A; Kumakura S; Uchida M; Barrett JC; Tsutsui T
Int J Cancer; 2003 Sep; 106(3):301-9. PubMed ID: 12845665
[TBL] [Abstract][Full Text] [Related]
6. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase.
Morales CP; Holt SE; Ouellette M; Kaur KJ; Yan Y; Wilson KS; White MA; Wright WE; Shay JW
Nat Genet; 1999 Jan; 21(1):115-8. PubMed ID: 9916803
[TBL] [Abstract][Full Text] [Related]
7. Association of p16(INK4a) and pRb inactivation with immortalization of human cells.
Tsutsui T; Kumakura S; Yamamoto A; Kanai H; Tamura Y; Kato T; Anpo M; Tahara H; Barrett JC
Carcinogenesis; 2002 Dec; 23(12):2111-7. PubMed ID: 12507935
[TBL] [Abstract][Full Text] [Related]
8. Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.
Vogt M; Haggblom C; Yeargin J; Christiansen-Weber T; Haas M
Cell Growth Differ; 1998 Feb; 9(2):139-46. PubMed ID: 9486850
[TBL] [Abstract][Full Text] [Related]
9. Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts.
Gorbunova V; Seluanov A; Pereira-Smith OM
J Biol Chem; 2003 Feb; 278(9):7692-8. PubMed ID: 12496279
[TBL] [Abstract][Full Text] [Related]
10. Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells.
Wadhwa R; Takano S; Taira K; Kaul SC
J Gene Med; 2004 Apr; 6(4):439-44. PubMed ID: 15079818
[TBL] [Abstract][Full Text] [Related]
11. DNA damage checkpoint kinase Chk2 triggers replicative senescence.
Gire V; Roux P; Wynford-Thomas D; Brondello JM; Dulic V
EMBO J; 2004 Jul; 23(13):2554-63. PubMed ID: 15192702
[TBL] [Abstract][Full Text] [Related]
12. The significance of p16INK4a in cell defenses against transformation.
Drayton S; Brookes S; Rowe J; Peters G
Cell Cycle; 2004 May; 3(5):611-5. PubMed ID: 15044857
[TBL] [Abstract][Full Text] [Related]
13. Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells.
Wen VW; Wu K; Baksh S; Hinshelwood RA; Lock RB; Clark SJ; Moore MA; Mackenzie KL
Cancer Res; 2006 Nov; 66(22):10691-700. PubMed ID: 17108106
[TBL] [Abstract][Full Text] [Related]
14. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis.
Gorbunova V; Seluanov A; Pereira-Smith OM
J Biol Chem; 2002 Oct; 277(41):38540-9. PubMed ID: 12140282
[TBL] [Abstract][Full Text] [Related]
15. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Rheinwald JG; Hahn WC; Ramsey MR; Wu JY; Guo Z; Tsao H; De Luca M; Catricalà C; O'Toole KM
Mol Cell Biol; 2002 Jul; 22(14):5157-72. PubMed ID: 12077343
[TBL] [Abstract][Full Text] [Related]
16. Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts.
de Magalhães JP; Chainiaux F; Remacle J; Toussaint O
FEBS Lett; 2002 Jul; 523(1-3):157-62. PubMed ID: 12123824
[TBL] [Abstract][Full Text] [Related]
17. Replicative senescence in human uroepithelial cells.
Puthenveettil JA; Burger MS; Reznikoff CA
Adv Exp Med Biol; 1999; 462():83-91. PubMed ID: 10599415
[TBL] [Abstract][Full Text] [Related]
18. Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.
Vaziri H; Benchimol S
Oncogene; 1999 Dec; 18(53):7676-80. PubMed ID: 10618707
[TBL] [Abstract][Full Text] [Related]
19. Genes involved in the control of cellular proliferative potential.
Reddel RR
Ann N Y Acad Sci; 1998 Nov; 854():8-19. PubMed ID: 9928415
[TBL] [Abstract][Full Text] [Related]
20. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Dickson MA; Hahn WC; Ino Y; Ronfard V; Wu JY; Weinberg RA; Louis DN; Li FP; Rheinwald JG
Mol Cell Biol; 2000 Feb; 20(4):1436-47. PubMed ID: 10648628
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
