301 related articles for article (PubMed ID: 15308760)
1. The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.
Witchel HJ; Dempsey CE; Sessions RB; Perry M; Milnes JT; Hancox JC; Mitcheson JS
Mol Pharmacol; 2004 Nov; 66(5):1201-12. PubMed ID: 15308760
[TBL] [Abstract][Full Text] [Related]
2. Structural determinants of HERG channel block by clofilium and ibutilide.
Perry M; de Groot MJ; Helliwell R; Leishman D; Tristani-Firouzi M; Sanguinetti MC; Mitcheson J
Mol Pharmacol; 2004 Aug; 66(2):240-9. PubMed ID: 15266014
[TBL] [Abstract][Full Text] [Related]
3. Structural determinants for high-affinity block of hERG potassium channels.
Mitcheson J; Perry M; Stansfeld P; Sanguinetti MC; Witchel H; Hancox J
Novartis Found Symp; 2005; 266():136-50; discussion 150-8. PubMed ID: 16050266
[TBL] [Abstract][Full Text] [Related]
4. Molecular determinants of HERG channel block.
Kamiya K; Niwa R; Mitcheson JS; Sanguinetti MC
Mol Pharmacol; 2006 May; 69(5):1709-16. PubMed ID: 16474003
[TBL] [Abstract][Full Text] [Related]
5. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.
Sanguinetti MC; Chen J; Fernandez D; Kamiya K; Mitcheson J; Sanchez-Chapula JA
Novartis Found Symp; 2005; 266():159-66; discussion 166-70. PubMed ID: 16050267
[TBL] [Abstract][Full Text] [Related]
6. Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.
Sánchez-Chapula JA; Navarro-Polanco RA; Sanguinetti MC
Naunyn Schmiedebergs Arch Pharmacol; 2004 Dec; 370(6):484-91. PubMed ID: 15558243
[TBL] [Abstract][Full Text] [Related]
7. Molecular determinants of dofetilide block of HERG K+ channels.
Ficker E; Jarolimek W; Kiehn J; Baumann A; Brown AM
Circ Res; 1998 Feb; 82(3):386-95. PubMed ID: 9486667
[TBL] [Abstract][Full Text] [Related]
8. High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872.
Thomas D; Wendt-Nordahl G; Röckl K; Ficker E; Brown AM; Kiehn J
J Pharmacol Exp Ther; 2001 May; 297(2):753-61. PubMed ID: 11303067
[TBL] [Abstract][Full Text] [Related]
9. Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.
Chen J; Seebohm G; Sanguinetti MC
Proc Natl Acad Sci U S A; 2002 Sep; 99(19):12461-6. PubMed ID: 12209010
[TBL] [Abstract][Full Text] [Related]
10. Blockade of the human ether-a-go-go-related gene potassium channel by ketamine.
Zhang P; Xing J; Luo A; Feng J; Liu Z; Gao C; Ma J
J Pharm Pharmacol; 2013 Sep; 65(9):1321-8. PubMed ID: 23927470
[TBL] [Abstract][Full Text] [Related]
11. High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.
Ridley JM; Milnes JT; Witchel HJ; Hancox JC
Biochem Biophys Res Commun; 2004 Dec; 325(3):883-91. PubMed ID: 15541373
[TBL] [Abstract][Full Text] [Related]
12. Molecular site of action of the antiarrhythmic drug propafenone at the voltage-operated potassium channel Kv2.1.
Madeja M; Leicher T; Friederich P; Punke MA; Haverkamp W; Musshoff U; Breithardt G; Speckmann EJ
Mol Pharmacol; 2003 Mar; 63(3):547-56. PubMed ID: 12606761
[TBL] [Abstract][Full Text] [Related]
13. The hERG potassium channel and drug trapping: insight from docking studies with propafenone derivatives.
Thai KM; Windisch A; Stork D; Weinzinger A; Schiesaro A; Guy RH; Timin EN; Hering S; Ecker GF
ChemMedChem; 2010 Mar; 5(3):436-42. PubMed ID: 20146282
[TBL] [Abstract][Full Text] [Related]
14. Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.
Sánchez-Chapula JA; Navarro-Polanco RA; Culberson C; Chen J; Sanguinetti MC
J Biol Chem; 2002 Jun; 277(26):23587-95. PubMed ID: 11960982
[TBL] [Abstract][Full Text] [Related]
15. Lidoflazine is a high affinity blocker of the HERG K(+)channel.
Ridley JM; Dooley PC; Milnes JT; Witchel HJ; Hancox JC
J Mol Cell Cardiol; 2004 May; 36(5):701-5. PubMed ID: 15135665
[TBL] [Abstract][Full Text] [Related]
16. Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration.
Kim YJ; Hong HK; Lee HS; Moh SH; Park JC; Jo SH; Choe H
J Cardiovasc Pharmacol; 2008 Dec; 52(6):485-93. PubMed ID: 19034039
[TBL] [Abstract][Full Text] [Related]
17. Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels.
Ficker E; Jarolimek W; Brown AM
Mol Pharmacol; 2001 Dec; 60(6):1343-8. PubMed ID: 11723241
[TBL] [Abstract][Full Text] [Related]
18. Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.
Yang BF; Xu DH; Xu CQ; Li Z; Du ZM; Wang HZ; Dong DL
Acta Pharmacol Sin; 2004 May; 25(5):554-60. PubMed ID: 15132818
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone.
Zitron E; Kiesecker C; Scholz E; Lück S; Bloehs R; Kathöfer S; Thomas D; Kiehn J; Kreye VA; Katus HA; Schoels W; Karle CA
Naunyn Schmiedebergs Arch Pharmacol; 2004 Aug; 370(2):146-56. PubMed ID: 15322737
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.
Thomas D; Hammerling BC; Wu K; Wimmer AB; Ficker EK; Kirsch GE; Kochan MC; Wible BA; Scholz EP; Zitron E; Kathöfer S; Kreye VA; Katus HA; Schoels W; Karle CA; Kiehn J
Br J Pharmacol; 2004 Jun; 142(3):485-94. PubMed ID: 15148258
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
