BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

272 related articles for article (PubMed ID: 15311269)

  • 1. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
    Li W; Johnson DJ; Esmon CT; Huntington JA
    Nat Struct Mol Biol; 2004 Sep; 11(9):857-62. PubMed ID: 15311269
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
    Dementiev A; Petitou M; Herbert JM; Gettins PG
    Nat Struct Mol Biol; 2004 Sep; 11(9):863-7. PubMed ID: 15311268
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin.
    Izaguirre G; Swanson R; Raja SM; Rezaie AR; Olson ST
    J Biol Chem; 2007 Nov; 282(46):33609-33622. PubMed ID: 17875649
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interaction of thrombin with antithrombin, heparin cofactor II, and protein C inhibitor.
    Whinna HC; Church FC
    J Protein Chem; 1993 Dec; 12(6):677-88. PubMed ID: 8136018
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Bivalent binding to gammaA/gamma'-fibrin engages both exosites of thrombin and protects it from inhibition by the antithrombin-heparin complex.
    Fredenburgh JC; Stafford AR; Leslie BA; Weitz JI
    J Biol Chem; 2008 Feb; 283(5):2470-7. PubMed ID: 18055456
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antithrombin conformational modulation by D-myo-inositol 3,4,5,6-tetrakisphosphate (TMI), a novel scaffold for the development of antithrombotic agents.
    Arantes PR; Pérez-Sánchez H; Verli H
    J Biomol Struct Dyn; 2018 Nov; 36(15):4045-4056. PubMed ID: 29173042
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structure of thrombin bound to heparin.
    Carter WJ; Cama E; Huntington JA
    J Biol Chem; 2005 Jan; 280(4):2745-9. PubMed ID: 15548541
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.
    Chuang YJ; Swanson R; Raja SM; Olson ST
    J Biol Chem; 2001 May; 276(18):14961-71. PubMed ID: 11278930
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanism of poly(acrylic acid) acceleration of antithrombin inhibition of thrombin: implications for the design of novel heparin mimics.
    Monien BH; Cheang KI; Desai UR
    J Med Chem; 2005 Aug; 48(16):5360-8. PubMed ID: 16078853
    [TBL] [Abstract][Full Text] [Related]  

  • 10. By increasing the affinity of heparin for fibrin, Zn(2+) promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin.
    Chan HH; Leslie BA; Stafford AR; Roberts RS; Al-Aswad NN; Fredenburgh JC; Weitz JI
    Biochemistry; 2012 Oct; 51(40):7964-73. PubMed ID: 22978548
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dynamic properties of the native free antithrombin from molecular dynamics simulations: computational evidence for solvent- exposed Arg393 side chain.
    Tóth L; Fekete A; Balogh G; Bereczky Z; Komáromi I
    J Biomol Struct Dyn; 2015 Sep; 33(9):2023-36. PubMed ID: 25483839
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular mapping of the thrombin-heparin cofactor II complex.
    Fortenberry YM; Whinna HC; Gentry HR; Myles T; Leung LL; Church FC
    J Biol Chem; 2004 Oct; 279(41):43237-44. PubMed ID: 15292227
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II.
    Becker DL; Fredenburgh JC; Stafford AR; Weitz JI
    J Biol Chem; 1999 Mar; 274(10):6226-33. PubMed ID: 10037709
    [TBL] [Abstract][Full Text] [Related]  

  • 14. On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.
    Mosier PD; Krishnasamy C; Kellogg GE; Desai UR
    PLoS One; 2012; 7(11):e48632. PubMed ID: 23152789
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation.
    Chuang YJ; Swanson R; Raja SM; Bock SC; Olson ST
    Biochemistry; 2001 Jun; 40(22):6670-9. PubMed ID: 11380262
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies.
    Rezaie AR; Olson ST
    Biochemistry; 2000 Oct; 39(39):12083-90. PubMed ID: 11009624
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.
    Izaguirre G; Aguila S; Qi L; Swanson R; Roth R; Rezaie AR; Gettins PG; Olson ST
    J Biol Chem; 2014 Dec; 289(49):34049-64. PubMed ID: 25331949
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of dysthrombins Quick I and II by heparin cofactor II and antithrombin.
    Phillips JE; Shirk RA; Whinna HC; Henriksen RA; Church FC
    J Biol Chem; 1993 Feb; 268(5):3321-7. PubMed ID: 8429008
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation.
    Johnson DJ; Li W; Adams TE; Huntington JA
    EMBO J; 2006 May; 25(9):2029-37. PubMed ID: 16619025
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reactivities of the S2 and S3 subsite residues of thrombin with the native and heparin-induced conformers of antithrombin.
    Rezaie AR
    Protein Sci; 1998 Feb; 7(2):349-57. PubMed ID: 9521111
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.