279 related articles for article (PubMed ID: 15319331)
21. Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.
Jalas JR; Hecht SS
Chem Res Toxicol; 2003 Jun; 16(6):782-93. PubMed ID: 12807362
[TBL] [Abstract][Full Text] [Related]
22. Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Zimmerman CL; Wu Z; Upadhyaya P; Hecht SS
Carcinogenesis; 2004 Jul; 25(7):1237-42. PubMed ID: 14988218
[TBL] [Abstract][Full Text] [Related]
23. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Zhang S; Wang M; Villalta PW; Lindgren BR; Upadhyaya P; Lao Y; Hecht SS
Chem Res Toxicol; 2009 May; 22(5):926-36. PubMed ID: 19358518
[TBL] [Abstract][Full Text] [Related]
24. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
Jalas JR; Ding X; Murphy SE
Drug Metab Dispos; 2003 Oct; 31(10):1199-202. PubMed ID: 12975327
[TBL] [Abstract][Full Text] [Related]
25. Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Ma B; Zarth AT; Carlson ES; Villalta PW; Upadhyaya P; Stepanov I; Hecht SS
Chem Res Toxicol; 2018 Jan; 31(1):48-57. PubMed ID: 29131934
[TBL] [Abstract][Full Text] [Related]
26. Formation of NADP(H) analogs of tobacco-specific nitrosamines in rat liver and pancreatic microsomes.
Peterson LA; Ng DK; Stearns RA; Hecht SS
Chem Res Toxicol; 1994; 7(5):599-608. PubMed ID: 7841337
[TBL] [Abstract][Full Text] [Related]
27. Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
Carmella SG; Borukhova A; Akerkar SA; Hecht SS
Cancer Epidemiol Biomarkers Prev; 1997 Feb; 6(2):113-20. PubMed ID: 9037562
[TBL] [Abstract][Full Text] [Related]
28. Metabolic study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to the enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in vitro in human bronchial epithelial cells using chiral capillary electrophoresis.
Yang Y; Yu C; Zhou M; Pang N; Li N; Nie H; Liao J; Bai Y; Liu H
J Chromatogr A; 2011 Sep; 1218(37):6505-10. PubMed ID: 21791338
[TBL] [Abstract][Full Text] [Related]
29. Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Stepanov I; Hecht SS
Chem Res Toxicol; 2009 Feb; 22(2):406-14. PubMed ID: 19166332
[TBL] [Abstract][Full Text] [Related]
30. Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4.
Wiener D; Doerge DR; Fang JL; Upadhyaya P; Lazarus P
Drug Metab Dispos; 2004 Jan; 32(1):72-9. PubMed ID: 14709623
[TBL] [Abstract][Full Text] [Related]
31. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.
Smith TJ; Guo Z; Gonzalez FJ; Guengerich FP; Stoner GD; Yang CS
Cancer Res; 1992 Apr; 52(7):1757-63. PubMed ID: 1312898
[TBL] [Abstract][Full Text] [Related]
32. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
Brown PJ; Bedard LL; Reid KR; Petsikas D; Massey TE
Drug Metab Dispos; 2007 Nov; 35(11):2086-94. PubMed ID: 17717079
[TBL] [Abstract][Full Text] [Related]
33. Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.
Smith TJ; Stoner GD; Yang CS
Cancer Res; 1995 Dec; 55(23):5566-73. PubMed ID: 7585636
[TBL] [Abstract][Full Text] [Related]
34. Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.
Staretz ME; Koenig LA; Hecht SS
Carcinogenesis; 1997 Sep; 18(9):1715-22. PubMed ID: 9328166
[TBL] [Abstract][Full Text] [Related]
35. Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.
Stambergova H; Skarydova L; Dunford JE; Wsol V
Chem Biol Interact; 2014 Jan; 207():52-7. PubMed ID: 24246760
[TBL] [Abstract][Full Text] [Related]
36. Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
Balbo S; Johnson CS; Kovi RC; James-Yi SA; O'Sullivan MG; Wang M; Le CT; Khariwala SS; Upadhyaya P; Hecht SS
Carcinogenesis; 2014 Dec; 35(12):2798-806. PubMed ID: 25269804
[TBL] [Abstract][Full Text] [Related]
37. Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Ma B; Zarth AT; Carlson ES; Villalta PW; Stepanov I; Hecht SS
Mutagenesis; 2017 Dec; 32(6):561-570. PubMed ID: 29186507
[TBL] [Abstract][Full Text] [Related]
38. Intestinal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats: Sex difference, inducibility and inhibition by phenethylisothiocyanate.
Schulze J; Malone A; Richter E
Carcinogenesis; 1995 Aug; 16(8):1733-40. PubMed ID: 7634397
[TBL] [Abstract][Full Text] [Related]
39. Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by hamster lung, liver and kidney.
Richter E; Friesenegger S; Engl J; Tricker AR
Toxicology; 2000 Apr; 144(1-3):83-91. PubMed ID: 10781874
[TBL] [Abstract][Full Text] [Related]
40. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver.
Schrader E; Hirsch-Ernst KI; Richter E; Foth H
Naunyn Schmiedebergs Arch Pharmacol; 1998 Mar; 357(3):336-43. PubMed ID: 9550307
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]