These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

358 related articles for article (PubMed ID: 15319485)

  • 1. Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.
    Milano J; McKay J; Dagenais C; Foster-Brown L; Pognan F; Gadient R; Jacobs RT; Zacco A; Greenberg B; Ciaccio PJ
    Toxicol Sci; 2004 Nov; 82(1):341-58. PubMed ID: 15319485
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
    van Es JH; van Gijn ME; Riccio O; van den Born M; Vooijs M; Begthel H; Cozijnsen M; Robine S; Winton DJ; Radtke F; Clevers H
    Nature; 2005 Jun; 435(7044):959-63. PubMed ID: 15959515
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition.
    Menke V; van Es JH; de Lau W; van den Born M; Kuipers EJ; Siersema PD; de Bruin RW; Kusters JG; Clevers H
    Dis Model Mech; 2010; 3(1-2):104-10. PubMed ID: 20075383
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of Notch-1 intracellular domain in activation of rheumatoid synoviocytes.
    Nakazawa M; Ishii H; Aono H; Takai M; Honda T; Aratani S; Fukamizu A; Nakamura H; Yoshino S; Kobata T; Nishioka K; Nakajima T
    Arthritis Rheum; 2001 Jul; 44(7):1545-54. PubMed ID: 11465706
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.
    Wang XD; Leow CC; Zha J; Tang Z; Modrusan Z; Radtke F; Aguet M; de Sauvage FJ; Gao WQ
    Dev Biol; 2006 Feb; 290(1):66-80. PubMed ID: 16360140
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
    Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Secretory cell hyperplasia and defects in Notch activity in a mouse model of leukocyte adhesion deficiency type II.
    Waterhouse CC; Johnson S; Phillipson M; Zbytnuik L; Petri B; Kelly M; Lowe JB; Kubes P
    Gastroenterology; 2010 Mar; 138(3):1079-90.e1-5. PubMed ID: 19900444
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM; Guss VL; Corsa JA; Loo A; Hansel SB; Zheng M; Munoz B; Srinivasan K; Wang B; Robertson BJ; Polson CT; Wang J; Roberts SB; Hendrick JP; Anderson JJ; Loy JK; Denton R; Verdoorn TA; Smith DW; Felsenstein KM
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.
    Minter LM; Turley DM; Das P; Shin HM; Joshi I; Lawlor RG; Cho OH; Palaga T; Gottipati S; Telfer JC; Kostura L; Fauq AH; Simpson K; Such KA; Miele L; Golde TE; Miller SD; Osborne BA
    Nat Immunol; 2005 Jul; 6(7):680-8. PubMed ID: 15991363
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.
    Curry CL; Reed LL; Golde TE; Miele L; Nickoloff BJ; Foreman KE
    Oncogene; 2005 Sep; 24(42):6333-44. PubMed ID: 15940249
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
    Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor.
    Searfoss GH; Jordan WH; Calligaro DO; Galbreath EJ; Schirtzinger LM; Berridge BR; Gao H; Higgins MA; May PC; Ryan TP
    J Biol Chem; 2003 Nov; 278(46):46107-16. PubMed ID: 12949072
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway.
    Krebs LT; Deftos ML; Bevan MJ; Gridley T
    Dev Biol; 2001 Oct; 238(1):110-9. PubMed ID: 11783997
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Requirement of Notch activation during regeneration of the intestinal epithelia.
    Okamoto R; Tsuchiya K; Nemoto Y; Akiyama J; Nakamura T; Kanai T; Watanabe M
    Am J Physiol Gastrointest Liver Physiol; 2009 Jan; 296(1):G23-35. PubMed ID: 19023031
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression.
    Lambiase A; Micera A; Pellegrini G; Merlo D; Rama P; De Luca M; Bonini S; Bonini S
    Invest Ophthalmol Vis Sci; 2009 Oct; 50(10):4622-30. PubMed ID: 19407015
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.
    Huppert SS; Ilagan MX; De Strooper B; Kopan R
    Dev Cell; 2005 May; 8(5):677-88. PubMed ID: 15866159
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.
    Fan X; Matsui W; Khaki L; Stearns D; Chun J; Li YM; Eberhart CG
    Cancer Res; 2006 Aug; 66(15):7445-52. PubMed ID: 16885340
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms.
    Shigeshiro M; Tanabe S; Suzuki T
    Brain Behav Immun; 2012 Oct; 26(7):1061-5. PubMed ID: 22683765
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors.
    Paris D; Quadros A; Patel N; DelleDonne A; Humphrey J; Mullan M
    Eur J Pharmacol; 2005 May; 514(1):1-15. PubMed ID: 15878319
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.