213 related articles for article (PubMed ID: 15322254)
1. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.
Koehler SE; Ladner RD
Mol Pharmacol; 2004 Sep; 66(3):620-6. PubMed ID: 15322254
[TBL] [Abstract][Full Text] [Related]
2. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
Webley SD; Welsh SJ; Jackman AL; Aherne GW
Br J Cancer; 2001 Aug; 85(3):446-52. PubMed ID: 11487279
[TBL] [Abstract][Full Text] [Related]
3. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.
Webley SD; Hardcastle A; Ladner RD; Jackman AL; Aherne GW
Br J Cancer; 2000 Sep; 83(6):792-9. PubMed ID: 10952785
[TBL] [Abstract][Full Text] [Related]
4. Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.
Canman CE; Lawrence TS; Shewach DS; Tang HY; Maybaum J
Cancer Res; 1993 Nov; 53(21):5219-24. PubMed ID: 8221659
[TBL] [Abstract][Full Text] [Related]
5. Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer.
Wilson PM; LaBonte MJ; Lenz HJ; Mack PC; Ladner RD
Mol Cancer Ther; 2012 Mar; 11(3):616-28. PubMed ID: 22172489
[TBL] [Abstract][Full Text] [Related]
6. Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target.
Harris JM; McIntosh EM; Muscat GE
J Mol Biol; 1999 Apr; 288(2):275-87. PubMed ID: 10329142
[TBL] [Abstract][Full Text] [Related]
7. dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae.
Tinkelenberg BA; Hansbury MJ; Ladner RD
Cancer Res; 2002 Sep; 62(17):4909-15. PubMed ID: 12208740
[TBL] [Abstract][Full Text] [Related]
8. Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
Curtin NJ; Harris AL; Aherne GW
Cancer Res; 1991 May; 51(9):2346-52. PubMed ID: 2015598
[TBL] [Abstract][Full Text] [Related]
9. The role of dUTPase and uracil-DNA repair in cancer chemotherapy.
Ladner RD
Curr Protein Pept Sci; 2001 Dec; 2(4):361-70. PubMed ID: 12374095
[TBL] [Abstract][Full Text] [Related]
10. dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells.
Yokogawa T; Yano W; Tsukioka S; Osada A; Wakasa T; Ueno H; Hoshino T; Yamamura K; Fujioka A; Fukuoka M; Ohkubo S; Matsuo K
Cancer Sci; 2021 Jan; 112(1):422-432. PubMed ID: 33140501
[TBL] [Abstract][Full Text] [Related]
11. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
Ren Q; Van Groeningen CJ; Hardcastle A; Aherne GW; Geoffroy F; Allegra CJ; Johnston PG; Grem JL
Oncol Res; 1997; 9(2):77-88. PubMed ID: 9167189
[TBL] [Abstract][Full Text] [Related]
12. Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.
Canman CE; Radany EH; Parsels LA; Davis MA; Lawrence TS; Maybaum J
Cancer Res; 1994 May; 54(9):2296-8. PubMed ID: 8162567
[TBL] [Abstract][Full Text] [Related]
13. dUTP pyrophosphatase as a potential target for chemotherapeutic drug development.
McIntosh EM; Haynes RH
Acta Biochim Pol; 1997; 44(2):159-71. PubMed ID: 9360704
[TBL] [Abstract][Full Text] [Related]
14. Modulation of human dUTPase using small interfering RNA.
Studebaker AW; Lafuse WP; Kloesel R; Williams MV
Biochem Biophys Res Commun; 2005 Feb; 327(1):306-10. PubMed ID: 15629463
[TBL] [Abstract][Full Text] [Related]
15. Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
Welsh SJ; Hobbs S; Aherne GW
Eur J Cancer; 2003 Feb; 39(3):378-87. PubMed ID: 12565992
[TBL] [Abstract][Full Text] [Related]
16. Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells.
Parsels LA; Parsels JD; Wagner LM; Loney TL; Radany EH; Maybaum J
Cancer Chemother Pharmacol; 1998; 42(5):357-62. PubMed ID: 9771948
[TBL] [Abstract][Full Text] [Related]
17. Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase.
Fischer JA; Muller-Weeks S; Caradonna SJ
Cancer Res; 2006 Sep; 66(17):8829-37. PubMed ID: 16951200
[TBL] [Abstract][Full Text] [Related]
18. Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.
Sakoff JA; Howitt IJ; Ackland SP; McCluskey A
Cancer Chemother Pharmacol; 2004 Mar; 53(3):225-32. PubMed ID: 14648018
[TBL] [Abstract][Full Text] [Related]
19. ICI D1694 and idoxuridine: a synergistic antitumor combination.
Pressacco J; Hedley DW; Erlichman C
Cancer Res; 1994 Jul; 54(14):3772-8. PubMed ID: 8033097
[TBL] [Abstract][Full Text] [Related]
20. Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.
Grogan BC; Parker JB; Guminski AF; Stivers JT
Biochemistry; 2011 Feb; 50(5):618-27. PubMed ID: 21222484
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
