BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

456 related articles for article (PubMed ID: 15325590)

  • 21. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 23. BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration.
    Yoon SY; Choi JE; Yoon JH; Huh JW; Kim DH
    Neurobiol Dis; 2006 May; 22(2):435-44. PubMed ID: 16480887
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A(beta) generation in autophagic vacuoles.
    Mizushima N
    J Cell Biol; 2005 Oct; 171(1):15-7. PubMed ID: 16216920
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?
    Nawrot B
    Acta Biochim Pol; 2004; 51(2):431-44. PubMed ID: 15218540
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
    Philipson O; Lannfelt L; Nilsson LN
    FEBS Lett; 2009 Sep; 583(18):3021-6. PubMed ID: 19683527
    [TBL] [Abstract][Full Text] [Related]  

  • 27. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K; Sakaguchi G; Horikoshi Y; Gray AJ; Maeda M; Hirata-Fukae C; Becker AG; Hosono M; Sakaguchi I; Minami SS; Nakajima Y; Li HF; Takeyama C; Kihara T; Ota A; Wong PC; Aisen PS; Kato A; Kinoshita N; Matsuoka Y
    J Neurochem; 2006 Dec; 99(6):1555-63. PubMed ID: 17083447
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P; Feyt C; Huysseune S; de Diesbach P; N'Kuli F; Courtoy PJ; Octave JN
    J Neurosci Res; 2006 Nov; 84(6):1311-22. PubMed ID: 16941495
    [TBL] [Abstract][Full Text] [Related]  

  • 29. [beta-amyloid cascade: current status and future directions].
    Iwatsubo T
    Rinsho Shinkeigaku; 2000 Dec; 40(12):1228-30. PubMed ID: 11464463
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels.
    Rakover I; Arbel M; Solomon B
    Neurodegener Dis; 2007; 4(5):392-402. PubMed ID: 17536186
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.
    Johnston JA; Liu WW; Todd SA; Coulson DT; Murphy S; Irvine GB; Passmore AP
    Biochem Soc Trans; 2005 Nov; 33(Pt 5):1096-100. PubMed ID: 16246054
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
    Teng FY; Tang BL
    Biochem Biophys Res Commun; 2005 Mar; 328(1):1-5. PubMed ID: 15670741
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation.
    Wozniak MA; Itzhaki RF; Shipley SJ; Dobson CB
    Neurosci Lett; 2007 Dec; 429(2-3):95-100. PubMed ID: 17980964
    [TBL] [Abstract][Full Text] [Related]  

  • 35. [Recent advances in Alzheimer's disease research--amyloid precursor protein trafficking, processing, and mutations in Alzheimer's disease linked genes].
    Fukatsu R; Tsuzuki K; Hayashi Y; Takamaru Y; Sasaki N; Yoshida T; Hatakeyama Y; Fuji N; Takahata N
    Hokkaido Igaku Zasshi; 1997 Jan; 72(1):3-11. PubMed ID: 9086357
    [TBL] [Abstract][Full Text] [Related]  

  • 36. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
    J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease.
    Vardy ER; Catto AJ; Hooper NM
    Trends Mol Med; 2005 Oct; 11(10):464-72. PubMed ID: 16153892
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.
    Pollack SJ; Lewis H
    Curr Opin Investig Drugs; 2005 Jan; 6(1):35-47. PubMed ID: 15675602
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
    Games D; Adams D; Alessandrini R; Barbour R; Berthelette P; Blackwell C; Carr T; Clemens J; Donaldson T; Gillespie F
    Nature; 1995 Feb; 373(6514):523-7. PubMed ID: 7845465
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 23.