BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

241 related articles for article (PubMed ID: 15341515)

  • 21. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
    Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
    Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
    Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
    [TBL] [Abstract][Full Text] [Related]  

  • 24. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.
    Beher D; Fricker M; Nadin A; Clarke EE; Wrigley JD; Li YM; Culvenor JG; Masters CL; Harrison T; Shearman MS
    Biochemistry; 2003 Jul; 42(27):8133-42. PubMed ID: 12846562
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M; Hattori C; Iwata N; Saido TC; Sasagawa N; Szabó B; Hashimoto Y; Maruyama K; Tanuma S; Kiso Y; Ishiura S
    J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Overexpression of calsenilin enhances gamma-secretase activity.
    Jo DG; Jang J; Kim BJ; Lundkvist J; Jung YK
    Neurosci Lett; 2005 Apr; 378(1):59-64. PubMed ID: 15763173
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM; Guss VL; Corsa JA; Loo A; Hansel SB; Zheng M; Munoz B; Srinivasan K; Wang B; Robertson BJ; Polson CT; Wang J; Roberts SB; Hendrick JP; Anderson JJ; Loy JK; Denton R; Verdoorn TA; Smith DW; Felsenstein KM
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [TBL] [Abstract][Full Text] [Related]  

  • 28. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
    FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD.
    Gowrishankar K; Zeidler MG; Vincenz C
    J Cell Sci; 2004 Aug; 117(Pt 18):4099-111. PubMed ID: 15280425
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
    Walker ES; Martinez M; Wang J; Goate A
    J Neurochem; 2006 Jul; 98(1):300-9. PubMed ID: 16805816
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Rat brain gamma-secretase activity is highly influenced by detergents.
    Frånberg J; Welander H; Aoki M; Winblad B; Tjernberg LO; Frykman S
    Biochemistry; 2007 Jun; 46(25):7647-54. PubMed ID: 17536783
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
    Winkler E; Hobson S; Fukumori A; Dümpelfeld B; Luebbers T; Baumann K; Haass C; Hopf C; Steiner H
    Biochemistry; 2009 Feb; 48(6):1183-97. PubMed ID: 19159235
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
    Qi Y; Morishima-Kawashima M; Sato T; Mitsumori R; Ihara Y
    Biochemistry; 2003 Feb; 42(4):1042-52. PubMed ID: 12549925
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
    Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
    J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
    Leuchtenberger S; Kummer MP; Kukar T; Czirr E; Teusch N; Sagi SA; Berdeaux R; Pietrzik CU; Ladd TB; Golde TE; Koo EH; Weggen S
    J Neurochem; 2006 Jan; 96(2):355-65. PubMed ID: 16300630
    [TBL] [Abstract][Full Text] [Related]  

  • 36. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
    J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
    Boo JH; Sohn JH; Kim JE; Song H; Mook-Jung I
    Biochem Biophys Res Commun; 2008 Aug; 372(4):913-7. PubMed ID: 18538664
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Functional plasticity in the substrate binding site of beta-secretase.
    Gorfe AA; Caflisch A
    Structure; 2005 Oct; 13(10):1487-98. PubMed ID: 16216580
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
    Kaether C; Schmitt S; Willem M; Haass C
    Traffic; 2006 Apr; 7(4):408-15. PubMed ID: 16536739
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.