241 related articles for article (PubMed ID: 15341515)
61. Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting.
Kametani F
FEBS Lett; 2004 Jul; 570(1-3):73-6. PubMed ID: 15251442
[TBL] [Abstract][Full Text] [Related]
62. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
Beher D; Wrigley JD; Owens AP; Shearman MS
J Neurochem; 2002 Aug; 82(3):563-75. PubMed ID: 12153480
[TBL] [Abstract][Full Text] [Related]
63. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design.
Park H; Lee S
J Am Chem Soc; 2003 Dec; 125(52):16416-22. PubMed ID: 14692784
[TBL] [Abstract][Full Text] [Related]
64. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.
Wrigley JD; Schurov I; Nunn EJ; Martin AC; Clarke EE; Ellis S; Bonnert TP; Shearman MS; Beher D
J Biol Chem; 2005 Apr; 280(13):12523-35. PubMed ID: 15613471
[TBL] [Abstract][Full Text] [Related]
65. Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F).
Poulsen SA; Watson AA; Fairlie DP; Craik DJ
J Struct Biol; 2000 Jun; 130(2-3):142-52. PubMed ID: 10940222
[TBL] [Abstract][Full Text] [Related]
66. Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.
Kornilova AY; Kim J; Laudon H; Wolfe MS
Biochemistry; 2006 Jun; 45(24):7598-604. PubMed ID: 16768455
[TBL] [Abstract][Full Text] [Related]
67. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.
Abbenante G; Kovacs DM; Leung DL; Craik DJ; Tanzi RE; Fairlie DP
Biochem Biophys Res Commun; 2000 Feb; 268(1):133-5. PubMed ID: 10652226
[TBL] [Abstract][Full Text] [Related]
68. Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis.
Hong L; Tang J
Biochemistry; 2004 Apr; 43(16):4689-95. PubMed ID: 15096037
[TBL] [Abstract][Full Text] [Related]
69. Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis.
Xiong B; Huang XQ; Shen LL; Shen JH; Luo XM; Shen X; Jiang HL; Chen KX
Acta Pharmacol Sin; 2004 Jun; 25(6):705-13. PubMed ID: 15169620
[TBL] [Abstract][Full Text] [Related]
70. Comparison of batch and perfusion culture in combination with pilot-scale expanded bed purification for the production of soluble recombinant beta-secretase.
Lüllau E; Kanttinen A; Hassel J; Berg M; Haag-Alvarsson A; Cederbrant K; Greenberg B; Fenge C; Schweikart F
Biotechnol Prog; 2003; 19(1):37-44. PubMed ID: 12573004
[TBL] [Abstract][Full Text] [Related]
71. Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.
Lichtenthaler SF; Wang R; Grimm H; Uljon SN; Masters CL; Beyreuther K
Proc Natl Acad Sci U S A; 1999 Mar; 96(6):3053-8. PubMed ID: 10077635
[TBL] [Abstract][Full Text] [Related]
72. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides.
Zhang L; Song L; Terracina G; Liu Y; Pramanik B; Parker E
Biochemistry; 2001 Apr; 40(16):5049-55. PubMed ID: 11305921
[TBL] [Abstract][Full Text] [Related]
73. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
Li YM; Lai MT; Xu M; Huang Q; DiMuzio-Mower J; Sardana MK; Shi XP; Yin KC; Shafer JA; Gardell SJ
Proc Natl Acad Sci U S A; 2000 May; 97(11):6138-43. PubMed ID: 10801983
[TBL] [Abstract][Full Text] [Related]
74. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
Kim SH; Yin YI; Li YM; Sisodia SS
J Biol Chem; 2004 Nov; 279(47):48615-9. PubMed ID: 15456788
[TBL] [Abstract][Full Text] [Related]
75. A general procedure for the purification of human beta-secretase expressed in Escherichia coli.
Sardana V; Xu B; Zugay-Murphy J; Chen Z; Sardana M; Darke PL; Munshi S; Kuo LC
Protein Expr Purif; 2004 Apr; 34(2):190-6. PubMed ID: 15003250
[TBL] [Abstract][Full Text] [Related]
76. Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.
Wu F; Schweizer C; Rudinskiy N; Taylor DM; Kazantsev A; Luthi-Carter R; Fraering PC
FASEB J; 2010 Jul; 24(7):2464-74. PubMed ID: 20237298
[TBL] [Abstract][Full Text] [Related]
77. The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
Yamasaki A; Eimer S; Okochi M; Smialowska A; Kaether C; Baumeister R; Haass C; Steiner H
J Neurosci; 2006 Apr; 26(14):3821-8. PubMed ID: 16597736
[TBL] [Abstract][Full Text] [Related]
78. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Esler WP; Das C; Campbell WA; Kimberly WT; Kornilova AY; Diehl TS; Ye W; Ostaszewski BL; Xia W; Selkoe DJ; Wolfe MS
Nat Cell Biol; 2002 May; 4(5):E110-1; author reply E111-2. PubMed ID: 11988746
[No Abstract] [Full Text] [Related]
79. Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.
Shiba T; Kametaka S; Kawasaki M; Shibata M; Waguri S; Uchiyama Y; Wakatsuki S
Traffic; 2004 Jun; 5(6):437-48. PubMed ID: 15117318
[TBL] [Abstract][Full Text] [Related]
80. Peptide-based, irreversible inhibitors of gamma-secretase activity.
Piper SC; Amtul Z; Galiñanes-Garcia L; Howard VG; Ziani-Cherif C; McLendon C; Rochette MJ; Fauq A; Golde TE; Murphy MP
Biochem Biophys Res Commun; 2003 Jun; 305(3):529-33. PubMed ID: 12763025
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]