These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 15342248)

  • 21. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
    Zhang Y; Desharnais J; Marsilje TH; Li C; Hedrick MP; Gooljarsingh LT; Tavassoli A; Benkovic SJ; Olson AJ; Boger DL; Wilson IA
    Biochemistry; 2003 May; 42(20):6043-56. PubMed ID: 12755606
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Identification of a 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitor: a tool to investigate the role of type 10 in Alzheimer's disease and prostate cancer.
    Ayan D; Maltais R; Poirier D
    ChemMedChem; 2012 Jul; 7(7):1181-4. PubMed ID: 22674910
    [No Abstract]   [Full Text] [Related]  

  • 23. Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase.
    Zhang R; Evans G; Rotella FJ; Westbrook EM; Beno D; Huberman E; Joachimiak A; Collart FR
    Biochemistry; 1999 Apr; 38(15):4691-700. PubMed ID: 10200156
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Infantile Neurodegeneration Results from Mutants of 17β-Hydroxysteroid Dehydrogenase Type 10 Rather Than Aβ-Binding Alcohol Dehydrogenase.
    He XY; Dobkin C; Brown WT; Yang SY
    Int J Mol Sci; 2023 May; 24(10):. PubMed ID: 37239833
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
    Krajewski WW; Collins R; Holmberg-Schiavone L; Jones TA; Karlberg T; Mowbray SL
    J Mol Biol; 2008 Jan; 375(1):217-28. PubMed ID: 18005987
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Crystal structure and biochemical properties of the (S)-3-hydroxybutyryl-CoA dehydrogenase PaaH1 from Ralstonia eutropha.
    Kim J; Chang JH; Kim KJ
    Biochem Biophys Res Commun; 2014 May; 448(2):163-8. PubMed ID: 24792376
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Predicted three-dimensional structure of the protease inhibitor domain of the Alzheimer's disease beta-amyloid precursor.
    Struthers RS; Kitson DH; Hagler AT
    Proteins; 1991; 9(1):1-11. PubMed ID: 2017431
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Mitochondrial Abeta: a potential cause of metabolic dysfunction in Alzheimer's disease.
    Chen X; Yan SD
    IUBMB Life; 2006 Dec; 58(12):686-94. PubMed ID: 17424907
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Functional plasticity in the substrate binding site of beta-secretase.
    Gorfe AA; Caflisch A
    Structure; 2005 Oct; 13(10):1487-98. PubMed ID: 16216580
    [TBL] [Abstract][Full Text] [Related]  

  • 30. 3-Hydroxyacyl-CoA and Alcohol Dehydrogenase Activities of Mitochondrial Type 10 17β-Hydroxysteroid Dehydrogenase in Neurodegeneration Study.
    He XY; Dobkin C; Brown WT; Yang SY
    J Alzheimers Dis; 2022; 88(4):1487-1497. PubMed ID: 35786658
    [TBL] [Abstract][Full Text] [Related]  

  • 31. In Vitro Assay Development and HTS of Small-Molecule Human ABAD/17β-HSD10 Inhibitors as Therapeutics in Alzheimer's Disease.
    Aitken L; Baillie G; Pannifer A; Morrison A; Jones PS; Smith TK; McElroy SP; Gunn-Moore FJ
    SLAS Discov; 2017 Jul; 22(6):676-685. PubMed ID: 28314118
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.
    El-Kabbani O; Carbone V; Darmanin C; Ishikura S; Hara A
    Proteins; 2005 Aug; 60(3):424-32. PubMed ID: 15906319
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Site-directed mutagenesis to enable and improve crystallizability of Candida tropicalis (3R)-hydroxyacyl-CoA dehydrogenase.
    Ylianttila MS; Qin YM; Hiltunen JK; Glumoff T
    Biochem Biophys Res Commun; 2004 Nov; 324(1):25-30. PubMed ID: 15464977
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde.
    Murakami Y; Ohsawa I; Kasahara T; Ohta S
    Neurobiol Aging; 2009 Feb; 30(2):325-9. PubMed ID: 17707551
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease.
    He XY; Schulz H; Yang SY
    J Biol Chem; 1998 Apr; 273(17):10741-6. PubMed ID: 9553139
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Insights into the structural basis of substrate recognition by histidinol-phosphate aminotransferase from Corynebacterium glutamicum.
    Marienhagen J; Sandalova T; Sahm H; Eggeling L; Schneider G
    Acta Crystallogr D Biol Crystallogr; 2008 Jun; 64(Pt 6):675-85. PubMed ID: 18560156
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
    Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
    J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species.
    Arampatzis S; Kadereit B; Schuster D; Balazs Z; Schweizer RA; Frey FJ; Langer T; Odermatt A
    J Mol Endocrinol; 2005 Aug; 35(1):89-101. PubMed ID: 16087724
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis.
    Vogan EM; Bellamacina C; He X; Liu HW; Ringe D; Petsko GA
    Biochemistry; 2004 Mar; 43(11):3057-67. PubMed ID: 15023057
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Crystal structure of isoflavone reductase from alfalfa (Medicago sativa L.).
    Wang X; He X; Lin J; Shao H; Chang Z; Dixon RA
    J Mol Biol; 2006 May; 358(5):1341-52. PubMed ID: 16600295
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.