536 related articles for article (PubMed ID: 15347683)
1. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway.
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
J Biol Chem; 2004 Nov; 279(47):49523-32. PubMed ID: 15347683
[TBL] [Abstract][Full Text] [Related]
2. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase.
Jung CG; Uhm KO; Horike H; Kim MJ; Misumi S; Ishida A; Ueda Y; Choi EK; Kim YS; Michikawa M; Hida H
J Alzheimers Dis; 2015; 43(4):1215-28. PubMed ID: 25147119
[TBL] [Abstract][Full Text] [Related]
3. Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells.
Ma G; Chen S; Wang X; Ba M; Yang H; Lu G
J Neurosci Res; 2005 Jun; 80(5):683-92. PubMed ID: 15880353
[TBL] [Abstract][Full Text] [Related]
4. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Lleó A; Berezovska O; Ramdya P; Fukumoto H; Raju S; Shah T; Hyman BT
J Biol Chem; 2003 Nov; 278(48):47370-5. PubMed ID: 12960155
[TBL] [Abstract][Full Text] [Related]
5. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Berezovska O; Jack C; Deng A; Gastineau N; Rebeck GW; Hyman BT
J Biol Chem; 2001 Aug; 276(32):30018-23. PubMed ID: 11408475
[TBL] [Abstract][Full Text] [Related]
6. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
[TBL] [Abstract][Full Text] [Related]
7. ERK1/2 is an endogenous negative regulator of the gamma-secretase activity.
Kim SK; Park HJ; Hong HS; Baik EJ; Jung MW; Mook-Jung I
FASEB J; 2006 Jan; 20(1):157-9. PubMed ID: 16293708
[TBL] [Abstract][Full Text] [Related]
8. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W
Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676
[TBL] [Abstract][Full Text] [Related]
9. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
Kume H; Maruyama K; Kametani F
Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
[TBL] [Abstract][Full Text] [Related]
10. Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways.
Webster NJ; Green KN; Settle VJ; Peers C; Vaughan PF
Brain Res Mol Brain Res; 2004 Nov; 130(1-2):161-9. PubMed ID: 15519686
[TBL] [Abstract][Full Text] [Related]
11. APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
Bergman A; Religa D; Karlström H; Laudon H; Winblad B; Lannfelt L; Lundkvist J; Näslund J
Exp Cell Res; 2003 Jul; 287(1):1-9. PubMed ID: 12799176
[TBL] [Abstract][Full Text] [Related]
12. X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
King GD; Cherian K; Turner RS
J Neurochem; 2004 Feb; 88(4):971-82. PubMed ID: 14756819
[TBL] [Abstract][Full Text] [Related]
13. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
[TBL] [Abstract][Full Text] [Related]
14. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.
Parvathy S; Ehrlich M; Pedrini S; Diaz N; Refolo L; Buxbaum JD; Bogush A; Petanceska S; Gandy S
J Neurochem; 2004 Aug; 90(4):1005-10. PubMed ID: 15287907
[TBL] [Abstract][Full Text] [Related]
15. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
[TBL] [Abstract][Full Text] [Related]
16. Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.
Gianni D; Zambrano N; Bimonte M; Minopoli G; Mercken L; Talamo F; Scaloni A; Russo T
J Biol Chem; 2003 Mar; 278(11):9290-7. PubMed ID: 12645527
[TBL] [Abstract][Full Text] [Related]
17. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
Chen F; Gu Y; Hasegawa H; Ruan X; Arawaka S; Fraser P; Westaway D; Mount H; St George-Hyslop P
J Biol Chem; 2002 Sep; 277(39):36521-6. PubMed ID: 12119298
[TBL] [Abstract][Full Text] [Related]
18. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Kimberly WT; Weinmaster G; Selkoe DJ; Hyman BT
J Neurochem; 2000 Aug; 75(2):583-93. PubMed ID: 10899933
[TBL] [Abstract][Full Text] [Related]
19. Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay.
Law BM; Guest AL; Pullen MWJ; Perkinton MS; Williams RJ
J Alzheimers Dis; 2018; 61(2):673-688. PubMed ID: 29254083
[TBL] [Abstract][Full Text] [Related]
20. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Yamamoto M; Kiyota T; Horiba M; Buescher JL; Walsh SM; Gendelman HE; Ikezu T
Am J Pathol; 2007 Feb; 170(2):680-92. PubMed ID: 17255335
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]