94 related articles for article (PubMed ID: 15351391)
1. Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes.
Priego EM; Balzarini J; Karlsson A; Camarasa MJ; Pérez-Pérez MJ
Bioorg Med Chem; 2004 Oct; 12(19):5079-90. PubMed ID: 15351391
[TBL] [Abstract][Full Text] [Related]
2. N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Hernandez AI; Familiar O; Negri A; Rodríguez-Barrios F; Gago F; Karlsson A; Camarasa MJ; Balzarini J; Pérez-Pérez MJ
J Med Chem; 2006 Dec; 49(26):7766-73. PubMed ID: 17181158
[TBL] [Abstract][Full Text] [Related]
3. 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.
Van Poecke S; Negri A; Gago F; Van Daele I; Solaroli N; Karlsson A; Balzarini J; Van Calenbergh S
J Med Chem; 2010 Apr; 53(7):2902-12. PubMed ID: 20218622
[TBL] [Abstract][Full Text] [Related]
4. Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.
Balzarini J; Van Daele I; Negri A; Solaroli N; Karlsson A; Liekens S; Gago F; Van Calenbergh S
Mol Pharmacol; 2009 May; 75(5):1127-36. PubMed ID: 19233899
[TBL] [Abstract][Full Text] [Related]
5. Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides.
Hernández AI; Balzarini J; Rodríguez-Barrios F; San-Félix A; Karlsson A; Gago F; Camarasa MJ; Pérez-Pérez MJ
Bioorg Med Chem Lett; 2003 Sep; 13(18):3027-30. PubMed ID: 12941326
[TBL] [Abstract][Full Text] [Related]
6. Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.
Hernández AI; Balzarini J; Karlsson A; Camarasa MJ; Pérez-Pérez MJ
J Med Chem; 2002 Sep; 45(19):4254-63. PubMed ID: 12213066
[TBL] [Abstract][Full Text] [Related]
7. Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.
Balzarini J; Hernández AI; Roche P; Esnouf R; Karlsson A; Camarasa MJ; Pérez-Pérez MJ
Mol Pharmacol; 2003 Feb; 63(2):263-70. PubMed ID: 12527796
[TBL] [Abstract][Full Text] [Related]
8. The design, synthesis and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase.
Martin JA; Thomas GJ; Merrett JH; Lambert RW; Bushnell DJ; Dunsdon SJ; Freeman AC; Hopkins RA; Johns IR; Keech E; Simmonite H; Kai-In PW; Holland M
Antivir Chem Chemother; 1998 Jan; 9(1):1-8. PubMed ID: 9875371
[TBL] [Abstract][Full Text] [Related]
9. Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.
Pomeisl K; Holý A; Votruba I; Pohl R
Bioorg Med Chem Lett; 2008 Feb; 18(4):1364-7. PubMed ID: 18221873
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
Manfredini S; Baraldi PG; Durini E; Porcu L; Angusti A; Vertuani S; Solaroli N; De Clercq E; Karlsson A; Balzarini J
Bioorg Med Chem Lett; 2001 May; 11(10):1329-32. PubMed ID: 11392548
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.
Van Poecke S; Negri A; Janssens J; Solaroli N; Karlsson A; Gago F; Balzarini J; Van Calenbergh S
Org Biomol Chem; 2011 Feb; 9(3):892-901. PubMed ID: 21127790
[TBL] [Abstract][Full Text] [Related]
12. Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.
Ciliberti N; Manfredini S; Angusti A; Durini E; Solaroli N; Vertuani S; Buzzoni L; Bonache MC; Ben-Shalom E; Karlsson A; Saada A; Balzarini J
Bioorg Med Chem; 2007 Apr; 15(8):3065-81. PubMed ID: 17324575
[TBL] [Abstract][Full Text] [Related]
13. Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.
Ostrowski T; Golankiewicz B; De Clercq E; Balzarini J
Bioorg Med Chem; 2005 Mar; 13(6):2089-96. PubMed ID: 15727862
[TBL] [Abstract][Full Text] [Related]
14. Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase.
Pomeisl K; Holý A; Votruba I
Nucleic Acids Symp Ser (Oxf); 2008; (52):657-8. PubMed ID: 18776551
[TBL] [Abstract][Full Text] [Related]
15. Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase.
Rajabi M; Mansell D; Freeman S; Bryce RA
Eur J Med Chem; 2011 Apr; 46(4):1165-71. PubMed ID: 21324566
[TBL] [Abstract][Full Text] [Related]
16. Characterization of three essential residues in the conserved ATP-binding region of Epstein-Barr virus thymidine kinase.
Wu CC; Hsu TY; Chen JY
Biochemistry; 2005 Mar; 44(12):4785-93. PubMed ID: 15779905
[TBL] [Abstract][Full Text] [Related]
17. Design and synthesis of novel metalloproteinase inhibitors.
Nakatani S; Ikura M; Yamamoto S; Nishita Y; Itadani S; Habashita H; Sugiura T; Ogawa K; Ohno H; Takahashi K; Nakai H; Toda M
Bioorg Med Chem; 2006 Aug; 14(15):5402-22. PubMed ID: 16621578
[TBL] [Abstract][Full Text] [Related]
18. Mitochondrial thymidine kinase inhibitors.
Pérez-Pérez MJ; Hernández AI; Priego EM; Rodríguez-Barrios F; Gago F; Camarasa MJ; Balzarini J
Curr Top Med Chem; 2005; 5(13):1205-19. PubMed ID: 16305527
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.
Ellis CD; Oppong KA; Laufersweiler MC; O'Neil SV; Soper DL; Wang Y; Wos JA; Fancher AN; Lu W; Suchanek MK; Wang RL; De B; Demuth TP
Bioorg Med Chem Lett; 2006 Sep; 16(18):4728-32. PubMed ID: 16870441
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.
Busnel O; Carreaux F; Carboni B; Pethe S; Goff SV; Mansuy D; Boucher JL
Bioorg Med Chem; 2005 Apr; 13(7):2373-9. PubMed ID: 15755639
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]