167 related articles for article (PubMed ID: 15367577)
1. Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter.
Song X; Li Y; Liu J; Mukundan M; Yan B
J Pharmacol Exp Ther; 2005 Feb; 312(2):571-82. PubMed ID: 15367577
[TBL] [Abstract][Full Text] [Related]
2. Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors.
Huss JM; Kasper CB
Mol Pharmacol; 2000 Jul; 58(1):48-57. PubMed ID: 10860926
[TBL] [Abstract][Full Text] [Related]
3. Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23.
Ma Y; Sachdeva K; Liu J; Song X; Li Y; Yang D; Deng R; Chichester CO; Yan B
Biochem Pharmacol; 2005 May; 69(9):1363-71. PubMed ID: 15826607
[TBL] [Abstract][Full Text] [Related]
4. Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23.
Shi D; Yang D; Yan B
Biochem Pharmacol; 2010 Oct; 80(8):1274-83. PubMed ID: 20599767
[TBL] [Abstract][Full Text] [Related]
5. Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor.
Guo GL; Staudinger J; Ogura K; Klaassen CD
Mol Pharmacol; 2002 Apr; 61(4):832-9. PubMed ID: 11901222
[TBL] [Abstract][Full Text] [Related]
6. The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
Zhang J; Kuehl P; Green ED; Touchman JW; Watkins PB; Daly A; Hall SD; Maurel P; Relling M; Brimer C; Yasuda K; Wrighton SA; Hancock M; Kim RB; Strom S; Thummel K; Russell CG; Hudson JR; Schuetz EG; Boguski MS
Pharmacogenetics; 2001 Oct; 11(7):555-72. PubMed ID: 11668216
[TBL] [Abstract][Full Text] [Related]
7. Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.
LeCluyse EL
Chem Biol Interact; 2001 May; 134(3):283-9. PubMed ID: 11336976
[TBL] [Abstract][Full Text] [Related]
8. Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation.
Ostberg T; Bertilsson G; Jendeberg L; Berkenstam A; Uppenberg J
Eur J Biochem; 2002 Oct; 269(19):4896-904. PubMed ID: 12354121
[TBL] [Abstract][Full Text] [Related]
9. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element.
Schuetz EG; Brimer C; Schuetz JD
Mol Pharmacol; 1998 Dec; 54(6):1113-7. PubMed ID: 9855641
[TBL] [Abstract][Full Text] [Related]
10. Pregnane X receptor-dependent and -independent effects of 2-acetylaminofluorene on cytochrome P450 3A23 expression and liver cell proliferation.
Sparfel L; Payen L; Gilot D; Sidaway J; Morel F; Guillouzo A; Fardel O
Biochem Biophys Res Commun; 2003 Jan; 300(2):278-84. PubMed ID: 12504080
[TBL] [Abstract][Full Text] [Related]
11. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S; Kurose K; Saito Y; Ozawa S; Hasegawa R; Komamura K; Ueno K; Kamakura S; Kitakaze M; Nakajima T; Matsumoto K; Akasawa A; Saito H; Sawada J
Drug Metab Dispos; 2004 Jan; 32(1):149-54. PubMed ID: 14709632
[TBL] [Abstract][Full Text] [Related]
12. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
Squires EJ; Sueyoshi T; Negishi M
J Biol Chem; 2004 Nov; 279(47):49307-14. PubMed ID: 15347657
[TBL] [Abstract][Full Text] [Related]
13. The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
Song X; Xie M; Zhang H; Li Y; Sachdeva K; Yan B
Drug Metab Dispos; 2004 Jan; 32(1):35-42. PubMed ID: 14709618
[TBL] [Abstract][Full Text] [Related]
14. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Staudinger J; Liu Y; Madan A; Habeebu S; Klaassen CD
Drug Metab Dispos; 2001 Nov; 29(11):1467-72. PubMed ID: 11602523
[TBL] [Abstract][Full Text] [Related]
15. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
Haines C; Chatham LR; Vardy A; Elcombe CR; Foster JR; Lake BG
Toxicology; 2018 May; 400-401():20-27. PubMed ID: 29548889
[TBL] [Abstract][Full Text] [Related]
16. Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor.
Nallani SC; Goodwin B; Maglich JM; Buckley DJ; Buckley AR; Desai PB
Drug Metab Dispos; 2003 May; 31(5):681-4. PubMed ID: 12695359
[TBL] [Abstract][Full Text] [Related]
17. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Jones SA; Moore LB; Shenk JL; Wisely GB; Hamilton GA; McKee DD; Tomkinson NC; LeCluyse EL; Lambert MH; Willson TM; Kliewer SA; Moore JT
Mol Endocrinol; 2000 Jan; 14(1):27-39. PubMed ID: 10628745
[TBL] [Abstract][Full Text] [Related]
18. The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.
Doricakova A; Novotna A; Vrzal R; Pavek P; Dvorak Z
Arch Toxicol; 2013 Feb; 87(2):291-301. PubMed ID: 22976785
[TBL] [Abstract][Full Text] [Related]
19. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Kliewer SA; Moore JT; Wade L; Staudinger JL; Watson MA; Jones SA; McKee DD; Oliver BB; Willson TM; Zetterström RH; Perlmann T; Lehmann JM
Cell; 1998 Jan; 92(1):73-82. PubMed ID: 9489701
[TBL] [Abstract][Full Text] [Related]
20. Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver.
Guo GL; Johnson DR; Klaassen CD
Drug Metab Dispos; 2002 Mar; 30(3):283-8. PubMed ID: 11854146
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]