142 related articles for article (PubMed ID: 15378008)
1. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.
Rodríguez-González A; Ramirez de Molina A; Fernández F; Lacal JC
Oncogene; 2004 Oct; 23(50):8247-59. PubMed ID: 15378008
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism.
Rodríguez-González A; Ramírez de Molina A; Bañez-Coronel M; Megias D; Lacal JC
Int J Oncol; 2005 Apr; 26(4):999-1008. PubMed ID: 15753995
[TBL] [Abstract][Full Text] [Related]
3. Choline kinase inhibitors as a novel approach for antiproliferative drug design.
Hernández-Alcoceba R; Saniger L; Campos J; Núñez MC; Khaless F; Gallo MA; Espinosa A; Lacal JC
Oncogene; 1997 Nov; 15(19):2289-301. PubMed ID: 9393874
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.
Ramírez de Molina A; Rodríguez-González A; Penalva V; Lucas L; Lacal JC
Biochem Biophys Res Commun; 2001 Jul; 285(4):873-9. PubMed ID: 11467831
[TBL] [Abstract][Full Text] [Related]
5. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.
Ramírez de Molina A; Gutiérrez R; Ramos MA; Silva JM; Silva J; Bonilla F; Sánchez JJ; Lacal JC
Oncogene; 2002 Jun; 21(27):4317-22. PubMed ID: 12082619
[TBL] [Abstract][Full Text] [Related]
6. A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis.
Báñez-Coronel M; Rodríguez-González A; Martín-Cantalejo Y; Sáez B; Soto J; Villa MJ; Braña MF; Lacal JC
Int J Oncol; 2004 Oct; 25(4):1097-103. PubMed ID: 15375561
[TBL] [Abstract][Full Text] [Related]
7. In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery.
Hernández-Alcoceba R; Fernández F; Lacal JC
Cancer Res; 1999 Jul; 59(13):3112-8. PubMed ID: 10397253
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.
Rodríguez-González A; Ramírez de Molina A; Fernández F; Ramos MA; del Carmen Núñez M; Campos J; Lacal JC
Oncogene; 2003 Dec; 22(55):8803-12. PubMed ID: 14654777
[TBL] [Abstract][Full Text] [Related]
9. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.
Ramírez de Molina A; Báñez-Coronel M; Gutiérrez R; Rodríguez-González A; Olmeda D; Megías D; Lacal JC
Cancer Res; 2004 Sep; 64(18):6732-9. PubMed ID: 15374991
[TBL] [Abstract][Full Text] [Related]
10. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation.
Sánchez AM; Malagarie-Cazenave S; Olea N; Vara D; Cuevas C; Díaz-Laviada I
Eur J Pharmacol; 2008 Apr; 584(2-3):237-45. PubMed ID: 18343365
[TBL] [Abstract][Full Text] [Related]
11. Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity.
Lucas L; Hernández-Alcoceba R; Penalva V; Lacal JC
Oncogene; 2001 Mar; 20(9):1110-7. PubMed ID: 11314048
[TBL] [Abstract][Full Text] [Related]
12. Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.
Ramírez de Molina A; Gallego-Ortega D; Sarmentero-Estrada J; Lagares D; Gómez Del Pulgar T; Bandrés E; García-Foncillas J; Lacal JC
Int J Biochem Cell Biol; 2008; 40(9):1753-63. PubMed ID: 18296102
[TBL] [Abstract][Full Text] [Related]
13. Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.
Al-Saffar NM; Troy H; Ramírez de Molina A; Jackson LE; Madhu B; Griffiths JR; Leach MO; Workman P; Lacal JC; Judson IR; Chung YL
Cancer Res; 2006 Jan; 66(1):427-34. PubMed ID: 16397258
[TBL] [Abstract][Full Text] [Related]
14. Choline kinase: an important target for cancer.
Janardhan S; Srivani P; Sastry GN
Curr Med Chem; 2006; 13(10):1169-86. PubMed ID: 16719778
[TBL] [Abstract][Full Text] [Related]
15. Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation, and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib.
Zhang GS; Liu DS; Dai CW; Li RJ
Am J Hematol; 2006 Apr; 81(4):242-55. PubMed ID: 16550520
[TBL] [Abstract][Full Text] [Related]
16. Novel 4-amino bis-pyridinium and bis-quinolinium derivatives as choline kinase inhibitors with antiproliferative activity against the human breast cancer SKBR-3 cell line.
Gómez-Pérez V; McSorley T; See Too WC; Konrad M; Campos JM
ChemMedChem; 2012 Apr; 7(4):663-9. PubMed ID: 22278967
[TBL] [Abstract][Full Text] [Related]
17. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway.
Ye M; Luo X; Li L; Shi Y; Tan M; Weng X; Li W; Liu J; Cao Y
Cancer Lett; 2007 Dec; 258(2):199-207. PubMed ID: 18029087
[TBL] [Abstract][Full Text] [Related]
18. Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells.
Jiménez-López JM; Carrasco MP; Marco C; Segovia JL
Biochem Pharmacol; 2006 Apr; 71(8):1114-21. PubMed ID: 16466701
[TBL] [Abstract][Full Text] [Related]
19. Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate.
Wang CT; Meng M; Zhang JC; Jin CJ; Jiang JJ; Ren HS; Jiang JM; Qin CY; Yu DQ
Chin Med J (Engl); 2008 Sep; 121(17):1707-11. PubMed ID: 19024104
[TBL] [Abstract][Full Text] [Related]
20. Influence of the linker in bispyridium compounds on the inhibition of human choline kinase.
Conejo-García A; Báñez-Coronel M; Sánchez-Martín RM; Rodríguez-González A; Ramos A; Ramírez de Molina A; Espinosa A; Gallo MA; Campos JM; Lacal JC
J Med Chem; 2004 Oct; 47(22):5433-40. PubMed ID: 15481981
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]