194 related articles for article (PubMed ID: 15379597)
1. Endotoxin recognition molecules MD-2 and toll-like receptor 4 as potential targets for therapeutic intervention of endotoxin shock.
Miyake K
Curr Drug Targets Inflamm Allergy; 2004 Sep; 3(3):291-7. PubMed ID: 15379597
[TBL] [Abstract][Full Text] [Related]
2. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.
Akashi S; Saitoh S; Wakabayashi Y; Kikuchi T; Takamura N; Nagai Y; Kusumoto Y; Fukase K; Kusumoto S; Adachi Y; Kosugi A; Miyake K
J Exp Med; 2003 Oct; 198(7):1035-42. PubMed ID: 14517279
[TBL] [Abstract][Full Text] [Related]
3. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex.
Fujihara M; Muroi M; Tanamoto K; Suzuki T; Azuma H; Ikeda H
Pharmacol Ther; 2003 Nov; 100(2):171-94. PubMed ID: 14609719
[TBL] [Abstract][Full Text] [Related]
4. Endotoxin recognition molecules, Toll-like receptor 4-MD-2.
Miyake K
Semin Immunol; 2004 Feb; 16(1):11-6. PubMed ID: 14751758
[TBL] [Abstract][Full Text] [Related]
5. MD-2: the Toll 'gatekeeper' in endotoxin signalling.
Gangloff M; Gay NJ
Trends Biochem Sci; 2004 Jun; 29(6):294-300. PubMed ID: 15276183
[TBL] [Abstract][Full Text] [Related]
6. Innate recognition of lipopolysaccharide by CD14 and toll-like receptor 4-MD-2: unique roles for MD-2.
Miyake K
Int Immunopharmacol; 2003 Jan; 3(1):119-28. PubMed ID: 12538042
[TBL] [Abstract][Full Text] [Related]
7. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
Schromm AB; Lien E; Henneke P; Chow JC; Yoshimura A; Heine H; Latz E; Monks BG; Schwartz DA; Miyake K; Golenbock DT
J Exp Med; 2001 Jul; 194(1):79-88. PubMed ID: 11435474
[TBL] [Abstract][Full Text] [Related]
8. Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling.
Hyakushima N; Mitsuzawa H; Nishitani C; Sano H; Kuronuma K; Konishi M; Himi T; Miyake K; Kuroki Y
J Immunol; 2004 Dec; 173(11):6949-54. PubMed ID: 15557191
[TBL] [Abstract][Full Text] [Related]
9. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1.
Miyake K; Ogata H; Nagai Y; Akashi S; Kimoto M
J Endotoxin Res; 2000; 6(5):389-91. PubMed ID: 11521060
[TBL] [Abstract][Full Text] [Related]
10. Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations.
Gioannini TL; Teghanemt A; Zhang D; Coussens NP; Dockstader W; Ramaswamy S; Weiss JP
Proc Natl Acad Sci U S A; 2004 Mar; 101(12):4186-91. PubMed ID: 15010525
[TBL] [Abstract][Full Text] [Related]
11. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
Visintin A; Latz E; Monks BG; Espevik T; Golenbock DT
J Biol Chem; 2003 Nov; 278(48):48313-20. PubMed ID: 12960171
[TBL] [Abstract][Full Text] [Related]
12. MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components.
Dziarski R; Wang Q; Miyake K; Kirschning CJ; Gupta D
J Immunol; 2001 Feb; 166(3):1938-44. PubMed ID: 11160242
[TBL] [Abstract][Full Text] [Related]
13. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.
da Silva Correia J; Soldau K; Christen U; Tobias PS; Ulevitch RJ
J Biol Chem; 2001 Jun; 276(24):21129-35. PubMed ID: 11274165
[TBL] [Abstract][Full Text] [Related]
14. Role of TLR4/MD-2 and RP105/MD-1 in innate recognition of lipopolysaccharide.
Kimoto M; Nagasawa K; Miyake K
Scand J Infect Dis; 2003; 35(9):568-72. PubMed ID: 14620136
[TBL] [Abstract][Full Text] [Related]
15. The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface.
Fujimoto T; Yamazaki S; Eto-Kimura A; Takeshige K; Muta T
J Biol Chem; 2004 Nov; 279(46):47431-7. PubMed ID: 15337750
[TBL] [Abstract][Full Text] [Related]
16. Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells.
Vives-Pi M; Somoza N; Fernández-Alvarez J; Vargas F; Caro P; Alba A; Gomis R; Labeta MO; Pujol-Borrell R
Clin Exp Immunol; 2003 Aug; 133(2):208-18. PubMed ID: 12869026
[TBL] [Abstract][Full Text] [Related]
17. Overexpression of CD14, TLR4, and MD-2 in HEK 293T cells does not prevent induction of in vitro endotoxin tolerance.
Medvedev AE; Vogel SN
J Endotoxin Res; 2003; 9(1):60-4. PubMed ID: 12691621
[TBL] [Abstract][Full Text] [Related]
18. Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Nagai Y; Akashi S; Nagafuku M; Ogata M; Iwakura Y; Akira S; Kitamura T; Kosugi A; Kimoto M; Miyake K
Nat Immunol; 2002 Jul; 3(7):667-72. PubMed ID: 12055629
[TBL] [Abstract][Full Text] [Related]
19. A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.
Kennedy MN; Mullen GE; Leifer CA; Lee C; Mazzoni A; Dileepan KN; Segal DM
J Biol Chem; 2004 Aug; 279(33):34698-704. PubMed ID: 15175334
[TBL] [Abstract][Full Text] [Related]
20. Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis.
Kawasaki K; Nogawa H; Nishijima M
J Immunol; 2003 Jan; 170(1):413-20. PubMed ID: 12496426
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
