These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

112 related articles for article (PubMed ID: 15379903)

  • 21. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
    FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
    Shiraishi H; Marutani T; Wang HQ; Maeda Y; Kurono Y; Takashima A; Araki W; Nishimura M; Yanagisawa K; Komano H
    Genes Cells; 2006 Jan; 11(1):83-93. PubMed ID: 16371134
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
    Laudon H; Winblad B; Näslund J
    Physiol Behav; 2007 Sep; 92(1-2):115-20. PubMed ID: 17588625
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
    J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum.
    Uchihara T; Sanjo N; Nakamura A; Han K; Song SY; St George-Hyslop P; Fraser PE
    Neurobiol Aging; 2006 Jan; 27(1):88-97. PubMed ID: 16298244
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
    Chen F; Tandon A; Sanjo N; Gu YJ; Hasegawa H; Arawaka S; Lee FJ; Ruan X; Mastrangelo P; Erdebil S; Wang L; Westaway D; Mount HT; Yankner B; Fraser PE; St George-Hyslop P
    J Biol Chem; 2003 May; 278(22):19974-9. PubMed ID: 12646573
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
    Nguyen V; Hawkins C; Bergeron C; Supala A; Huang J; Westaway D; St George-Hyslop P; Rozmahel R
    Brain Res; 2006 May; 1086(1):76-84. PubMed ID: 16626651
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.
    Oh YS; Turner RJ
    Biochem Biophys Res Commun; 2006 Jul; 346(1):330-4. PubMed ID: 16756946
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.
    Li J; Fici GJ; Mao CA; Myers RL; Shuang R; Donoho GP; Pauley AM; Himes CS; Qin W; Kola I; Merchant KM; Nye JS
    J Biol Chem; 2003 Aug; 278(35):33445-9. PubMed ID: 12815056
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The Nicastrin ectodomain adopts a highly thermostable structure.
    Fluhrer R; Kamp F; Grammer G; Nuscher B; Steiner H; Beyer K; Haass C
    Biol Chem; 2011 Nov; 392(11):995-1001. PubMed ID: 21848507
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation.
    Sakuma K; Nakao R; Yamasa Y; Yasuhara M
    Biochim Biophys Acta; 2006 Jun; 1760(6):980-7. PubMed ID: 16595164
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts.
    Behbahani H; Shabalina IG; Wiehager B; Concha H; Hultenby K; Petrovic N; Nedergaard J; Winblad B; Cowburn RF; Ankarcrona M
    J Neurosci Res; 2006 Sep; 84(4):891-902. PubMed ID: 16883555
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.
    Suga K; Saito A; Tomiyama T; Mori H; Akagawa K
    J Neurochem; 2005 Jul; 94(2):425-39. PubMed ID: 15998293
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
    Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; Williamson NA; McLean CA; Masters CL; Evin G
    Eur J Biochem; 2004 Jan; 271(2):375-85. PubMed ID: 14717705
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Presenilin function and gamma-secretase activity.
    Brunkan AL; Goate AM
    J Neurochem; 2005 May; 93(4):769-92. PubMed ID: 15857382
    [TBL] [Abstract][Full Text] [Related]  

  • 39. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
    Wang J; Beher D; Nyborg AC; Shearman MS; Golde TE; Goate A
    J Neurochem; 2006 Jan; 96(1):218-27. PubMed ID: 16305624
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
    Prokop S; Haass C; Steiner H
    J Neurochem; 2005 Jul; 94(1):57-62. PubMed ID: 15953349
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.