BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

450 related articles for article (PubMed ID: 15448015)

  • 1. Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
    Wang Y; Zhao R; Goldman ID
    Clin Cancer Res; 2004 Sep; 10(18 Pt 1):6256-64. PubMed ID: 15448015
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier.
    Zhao R; Chattopadhyay S; Hanscom M; Goldman ID
    Clin Cancer Res; 2004 Dec; 10(24):8735-42. PubMed ID: 15623659
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
    Zhao R; Hanscom M; Chattopadhyay S; Goldman ID
    Cancer Res; 2004 May; 64(9):3313-9. PubMed ID: 15126375
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells.
    Chattopadhyay S; Wang Y; Zhao R; Goldman ID
    Clin Cancer Res; 2004 Dec; 10(23):7986-93. PubMed ID: 15585634
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
    Westerhof GR; Rijnboutt S; Schornagel JH; Pinedo HM; Peters GJ; Jansen G
    Cancer Res; 1995 Sep; 55(17):3795-802. PubMed ID: 7641196
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
    Zhao R; Zhang S; Hanscom M; Chattopadhyay S; Goldman ID
    Clin Cancer Res; 2005 Feb; 11(3):1294-301. PubMed ID: 15709201
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells.
    Kühnel JM; Chiao JH; Sirotnak FM
    J Cell Physiol; 2000 Sep; 184(3):364-72. PubMed ID: 10911368
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
    Mauritz R; Peters GJ; Priest DG; Assaraf YG; Drori S; Kathmann I; Noordhuis P; Bunni MA; Rosowsky A; Schornagel JH; Pinedo HM; Jansen G
    Biochem Pharmacol; 2002 Jan; 63(2):105-15. PubMed ID: 11841783
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier.
    Zhao R; Gao F; Hanscom M; Goldman ID
    Clin Cancer Res; 2004 Jan; 10(2):718-27. PubMed ID: 14760095
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed.
    Wang Y; Zhao R; Chattopadhyay S; Goldman ID
    Cancer Res; 2002 Nov; 62(22):6434-7. PubMed ID: 12438230
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR; Schornagel JH; Kathmann I; Jackman AL; Rosowsky A; Forsch RA; Hynes JB; Boyle FT; Peters GJ; Pinedo HM
    Mol Pharmacol; 1995 Sep; 48(3):459-71. PubMed ID: 7565626
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.
    Zhao R; Hanscom M; Goldman ID
    Biochim Biophys Acta; 2005 Aug; 1715(1):57-64. PubMed ID: 16109384
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed.
    Zhao R; Goldman ID
    Cancer Metastasis Rev; 2007 Mar; 26(1):129-39. PubMed ID: 17340171
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
    Mauritz R; Peters GJ; Kathmann I; Teshale H; Noordhuis P; Comijn EM; Pinedo HM; Jansen G
    Cancer Chemother Pharmacol; 2008 Nov; 62(6):937-48. PubMed ID: 18283461
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
    Zhao R; Qiu A; Tsai E; Jansen M; Akabas MH; Goldman ID
    Mol Pharmacol; 2008 Sep; 74(3):854-62. PubMed ID: 18524888
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
    Zhao R; Babani S; Gao F; Liu L; Goldman ID
    Clin Cancer Res; 2000 Sep; 6(9):3687-95. PubMed ID: 10999762
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
    Zhao R; Gao F; Babani S; Goldman ID
    Clin Cancer Res; 2000 Aug; 6(8):3304-11. PubMed ID: 10955817
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.
    Theti DS; Jackman AL
    Clin Cancer Res; 2004 Feb; 10(3):1080-9. PubMed ID: 14871988
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
    Jansen G; Mauritz R; Drori S; Sprecher H; Kathmann I; Bunni M; Priest DG; Noordhuis P; Schornagel JH; Pinedo HM; Peters GJ; Assaraf YG
    J Biol Chem; 1998 Nov; 273(46):30189-98. PubMed ID: 9804775
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells.
    Henderson GB; Strauss BP
    Cancer Res; 1990 Mar; 50(6):1709-14. PubMed ID: 2306724
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.