These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 1544836)

  • 1. Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233.
    Giaccia AJ; Biedermann KA; Tosto LM; Minchinton AI; Kovacs MS; Brown JM
    Int J Radiat Oncol Biol Phys; 1992; 22(4):681-4. PubMed ID: 1544836
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
    Siim BG; Pruijn FB; Sturman JR; Hogg A; Hay MP; Brown JM; Wilson WR
    Cancer Res; 2004 Jan; 64(2):736-42. PubMed ID: 14744792
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.
    Hunter FW; Wang J; Patel R; Hsu HL; Hickey AJ; Hay MP; Wilson WR
    Biochem Pharmacol; 2012 Mar; 83(5):574-85. PubMed ID: 22182429
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pre- and post-irradiation radiosensitization by SR 4233.
    Zeman EM; Brown JM
    Int J Radiat Oncol Biol Phys; 1989 Apr; 16(4):967-71. PubMed ID: 2703404
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation.
    Wang J; Biedermann KA; Brown JM
    Cancer Res; 1992 Aug; 52(16):4473-7. PubMed ID: 1643639
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
    Elwell JH; Siim BG; Evans JW; Brown JM
    Biochem Pharmacol; 1997 Jul; 54(2):249-57. PubMed ID: 9271329
    [TBL] [Abstract][Full Text] [Related]  

  • 7. SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures.
    Biedermann KA; Wang J; Graham RP; Brown JM
    Br J Cancer; 1991 Mar; 63(3):358-62. PubMed ID: 2003976
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells.
    Zeman EM; Brown JM; Lemmon MJ; Hirst VK; Lee WW
    Int J Radiat Oncol Biol Phys; 1986 Jul; 12(7):1239-42. PubMed ID: 3744945
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.
    Giaccia AJ; Lewis AD; Denko NC; Cholon A; Evans JW; Waldren CA; Stamato TD; Brown JM
    Cancer Res; 1991 Aug; 51(16):4463-9. PubMed ID: 1714344
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233.
    Zeman EM; Hirst VK; Lemmon MJ; Brown JM
    Radiother Oncol; 1988 Jul; 12(3):209-18. PubMed ID: 3175048
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides.
    Monge A; Palop JA; López de Ceráin A; Senador V; Martínez-Crespo FJ; Sainz Y; Narro S; García E; de Miguel C; González M
    J Med Chem; 1995 May; 38(10):1786-92. PubMed ID: 7752202
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Isolation and characterization of a cell line resistant to 5-[3-(2-nitro-1-imidazoyl)-propyl]-phenanthridinium bromide (2-NLP-3), a DNA-intercalating hypoxic cell radiosensitizer and cytotoxin.
    Cowan DS; McClelland RA; Rauth AM
    Biochem Pharmacol; 1995 Jun; 50(1):61-8. PubMed ID: 7605346
    [TBL] [Abstract][Full Text] [Related]  

  • 13. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.
    Brown JM
    Br J Cancer; 1993 Jun; 67(6):1163-70. PubMed ID: 8512801
    [TBL] [Abstract][Full Text] [Related]  

  • 14. SR 4233: a tumor specific radiosensitizer active in fractionated radiation regimes.
    Brown JM; Lemmon MJ
    Radiother Oncol; 1991; 20 Suppl 1():151-6. PubMed ID: 2020764
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
    Hwang JT; Greenberg MM; Fuchs T; Gates KS
    Biochemistry; 1999 Oct; 38(43):14248-55. PubMed ID: 10571998
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides.
    Qi W; Yadav P; Hong CR; Stevenson RJ; Hay MP; Anderson RF
    Molecules; 2022 Jan; 27(3):. PubMed ID: 35164077
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
    Riley RJ; Hemingway SA; Graham MA; Workman P
    Biochem Pharmacol; 1993 Mar; 45(5):1065-77. PubMed ID: 8461036
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro.
    Siim BG; van Zijl PL; Brown JM
    Br J Cancer; 1996 Apr; 73(8):952-60. PubMed ID: 8611431
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity.
    Baker MA; Zeman EM; Hirst VK; Brown JM
    Cancer Res; 1988 Nov; 48(21):5947-52. PubMed ID: 3167847
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing.
    Minchinton AI; Brown JM
    Br J Cancer; 1992 Dec; 66(6):1053-8. PubMed ID: 1457345
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.