BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

128 related articles for article (PubMed ID: 15450421)

  • 1. Spontaneous multiple mutations show both proximal spacing consistent with chronocoordinate events and alterations with p53-deficiency.
    Hill KA; Wang J; Farwell KD; Scaringe WA; Sommer SS
    Mutat Res; 2004 Oct; 554(1-2):223-40. PubMed ID: 15450421
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Most spontaneous tumors in a mouse model of Li-Fraumeni syndrome do not have a mutator phenotype.
    Hill KA; Buettner VL; Heidt A; Chen LL; Li W; Gonzalez KD; Wang JC; Scaringe WA; Sommer SS
    Carcinogenesis; 2006 Sep; 27(9):1860-6. PubMed ID: 16597646
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A novel germline mutation in Big Blue mice.
    Crabbe RA; Prtenjaca A; Tarnowski HE; Hill KA
    Environ Mol Mutagen; 2009 Mar; 50(2):114-20. PubMed ID: 19107908
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.
    Chen Z; Feng J; Buzin CH; Sommer SS
    PLoS One; 2008; 3(11):e3714. PubMed ID: 19005564
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types.
    Hill KA; Buettner VL; Halangoda A; Kunishige M; Moore SR; Longmate J; Scaringe WA; Sommer SS
    Environ Mol Mutagen; 2004; 43(2):110-20. PubMed ID: 14991751
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evidence that proximal multiple mutations in Big Blue transgenic mice are dependent events.
    Buettner VL; Hill KA; Scaringe WA; Sommer SS
    Mutat Res; 2000 Sep; 452(2):219-29. PubMed ID: 11024481
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Germline TP53 mutations and Li-Fraumeni syndrome.
    Varley JM
    Hum Mutat; 2003 Mar; 21(3):313-20. PubMed ID: 12619118
    [TBL] [Abstract][Full Text] [Related]  

  • 8. p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain.
    Nishino H; Knöll A; Buettner VL; Frisk CS; Maruta Y; Haavik J; Sommer SS
    Oncogene; 1995 Jul; 11(2):263-70. PubMed ID: 7624143
    [TBL] [Abstract][Full Text] [Related]  

  • 9. EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids.
    Chen Z; Feng J; Saldivar JS; Gu D; Bockholt A; Sommer SS
    Oncogene; 2008 Jul; 27(31):4336-43. PubMed ID: 18372921
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Li-Fraumeni and Li-Fraumeni-like syndrome mutations in p53 are associated with exonic methylation and splicing regulatory elements.
    Kouidou S; Malousi A; Maglaveras N
    Mol Carcinog; 2009 Oct; 48(10):895-902. PubMed ID: 19367569
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice.
    Buettner VL; Hill KA; Nishino H; Schaid DJ; Frisk CS; Sommer SS
    Oncogene; 1996 Dec; 13(11):2407-13. PubMed ID: 8957082
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of the molecular mechanisms involved in the gain of function of a Li-Fraumeni TP53 mutation.
    Capponcelli S; Pedrini E; Cerone MA; Corti V; Fontanesi S; Alessio M; Bachi A; Soddu S; Ribatti D; Picci P; Helman LJ; Cantelli-Forti G; Sangiorgi L
    Hum Mutat; 2005 Aug; 26(2):94-103. PubMed ID: 15977174
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Silent mutations in the gene encoding the p53 protein are preferentially located in conserved amino acid positions and splicing enhancers.
    Lamolle G; Marin M; Alvarez-Valin F
    Mutat Res; 2006 Aug; 600(1-2):102-12. PubMed ID: 16650445
    [TBL] [Abstract][Full Text] [Related]  

  • 14. High frequency of de novo mutations in Li-Fraumeni syndrome.
    Gonzalez KD; Buzin CH; Noltner KA; Gu D; Li W; Malkin D; Sommer SS
    J Med Genet; 2009 Oct; 46(10):689-93. PubMed ID: 19556618
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Joint effects of germ-line p53 mutation and sex on cancer risk in Li-Fraumeni syndrome.
    Wu CC; Shete S; Amos CI; Strong LC
    Cancer Res; 2006 Aug; 66(16):8287-92. PubMed ID: 16912210
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations.
    Gonzalez KD; Noltner KA; Buzin CH; Gu D; Wen-Fong CY; Nguyen VQ; Han JH; Lowstuter K; Longmate J; Sommer SS; Weitzel JN
    J Clin Oncol; 2009 Mar; 27(8):1250-6. PubMed ID: 19204208
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population.
    Yamada H; Shinmura K; Okudela K; Goto M; Suzuki M; Kuriki K; Tsuneyoshi T; Sugimura H
    Carcinogenesis; 2007 Sep; 28(9):2013-8. PubMed ID: 17690113
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.
    Olive KP; Tuveson DA; Ruhe ZC; Yin B; Willis NA; Bronson RT; Crowley D; Jacks T
    Cell; 2004 Dec; 119(6):847-60. PubMed ID: 15607980
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Spontaneous and induced chromosomal damage and mutations in Bloom Syndrome mice.
    Wang Y; Heddle JA
    Mutat Res; 2004 Oct; 554(1-2):131-7. PubMed ID: 15450411
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families.
    Achatz MI; Olivier M; Le Calvez F; Martel-Planche G; Lopes A; Rossi BM; Ashton-Prolla P; Giugliani R; Palmero EI; Vargas FR; Da Rocha JC; Vettore AL; Hainaut P
    Cancer Lett; 2007 Jan; 245(1-2):96-102. PubMed ID: 16494995
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.