917 related articles for article (PubMed ID: 15452193)
21. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
Lefranc-Jullien S; Sunyach C; Checler F
J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
[TBL] [Abstract][Full Text] [Related]
22. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.
Yu WH; Kumar A; Peterhoff C; Shapiro Kulnane L; Uchiyama Y; Lamb BT; Cuervo AM; Nixon RA
Int J Biochem Cell Biol; 2004 Dec; 36(12):2531-40. PubMed ID: 15325590
[TBL] [Abstract][Full Text] [Related]
23. Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Kurt MA; Davies DC; Kidd M; Duff K; Rolph SC; Jennings KH; Howlett DR
Exp Neurol; 2001 Sep; 171(1):59-71. PubMed ID: 11520121
[TBL] [Abstract][Full Text] [Related]
24. A comparative assessment of gamma-secretase activity in transgenic and non-transgenic rodent brain.
Goggi JL; Lewis HD; Mok J; Harrison T; Shearman MS; Atack JR; Best JD
J Neurosci Methods; 2006 Oct; 157(2):246-52. PubMed ID: 16859750
[TBL] [Abstract][Full Text] [Related]
25. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
Zhou S; Zhou H; Walian PJ; Jap BK
Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
[TBL] [Abstract][Full Text] [Related]
26. The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice.
Lanz TA; Himes CS; Pallante G; Adams L; Yamazaki S; Amore B; Merchant KM
J Pharmacol Exp Ther; 2003 Jun; 305(3):864-71. PubMed ID: 12626636
[TBL] [Abstract][Full Text] [Related]
27. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
[TBL] [Abstract][Full Text] [Related]
28. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
[TBL] [Abstract][Full Text] [Related]
29. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
Ohno M; Chang L; Tseng W; Oakley H; Citron M; Klein WL; Vassar R; Disterhoft JF
Eur J Neurosci; 2006 Jan; 23(1):251-60. PubMed ID: 16420434
[TBL] [Abstract][Full Text] [Related]
30. Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
Philipson O; Lannfelt L; Nilsson LN
FEBS Lett; 2009 Sep; 583(18):3021-6. PubMed ID: 19683527
[TBL] [Abstract][Full Text] [Related]
31. Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice.
van Groen T; Kiliaan AJ; Kadish I
Neurobiol Dis; 2006 Sep; 23(3):653-62. PubMed ID: 16829076
[TBL] [Abstract][Full Text] [Related]
32. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
33. Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice.
Zohar O; Pick CG; Cavallaro S; Chapman J; Katzav A; Milman A; Alkon DL
Neurobiol Aging; 2005; 26(8):1167-75. PubMed ID: 15917100
[TBL] [Abstract][Full Text] [Related]
34. High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain.
Güntert A; Döbeli H; Bohrmann B
Neuroscience; 2006 Dec; 143(2):461-75. PubMed ID: 17008022
[TBL] [Abstract][Full Text] [Related]
35. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
36. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
[TBL] [Abstract][Full Text] [Related]
37. Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.
Portelius E; Brinkmalm G; Tran AJ; Zetterberg H; Westman-Brinkmalm A; Blennow K
Neurodegener Dis; 2009; 6(3):87-94. PubMed ID: 19229112
[TBL] [Abstract][Full Text] [Related]
38. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
Siman R; Salidas S
Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
[TBL] [Abstract][Full Text] [Related]
39. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
40. Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.
Li L; Zhang X; Yang D; Luo G; Chen S; Le W
Neurobiol Aging; 2009 Jul; 30(7):1091-8. PubMed ID: 18063223
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
