110 related articles for article (PubMed ID: 15454209)
1. 5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa.
Batt DG; Qiao JX; Modi DP; Houghton GC; Pierson DA; Rossi KA; Luettgen JM; Knabb RM; Jadhav PK; Wexler RR
Bioorg Med Chem Lett; 2004 Nov; 14(21):5269-73. PubMed ID: 15454209
[TBL] [Abstract][Full Text] [Related]
2. SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa.
Smallheer JM; Alexander RS; Wang J; Wang S; Nakajima S; Rossi KA; Smallwood A; Barbera F; Burdick D; Luettgen JM; Knabb RM; Wexler RR; Jadhav PK
Bioorg Med Chem Lett; 2004 Nov; 14(21):5263-7. PubMed ID: 15454208
[TBL] [Abstract][Full Text] [Related]
3. 5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.
Qiao JX; Cheng X; Modi DP; Rossi KA; Luettgen JM; Knabb RM; Jadhav PK; Wexler RR
Bioorg Med Chem Lett; 2005 Jan; 15(1):29-35. PubMed ID: 15582405
[TBL] [Abstract][Full Text] [Related]
4. Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.
Nazaré M; Will DW; Matter H; Schreuder H; Ritter K; Urmann M; Essrich M; Bauer A; Wagner M; Czech J; Lorenz M; Laux V; Wehner V
J Med Chem; 2005 Jul; 48(14):4511-25. PubMed ID: 15999990
[TBL] [Abstract][Full Text] [Related]
5. Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.
Wang S; Beck R; Burd A; Blench T; Marlin F; Ayele T; Buxton S; Dagostin C; Malic M; Joshi R; Barry J; Sajad M; Cheung C; Shaikh S; Chahwala S; Chander C; Baumgartner C; Holthoff HP; Murray E; Blackney M; Giddings A
J Med Chem; 2010 Feb; 53(4):1473-82. PubMed ID: 20121197
[TBL] [Abstract][Full Text] [Related]
6. Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus rotundus).
Apitz-Castro R; Béguin S; Tablante A; Bartoli F; Holt JC; Hemker HC
Thromb Haemost; 1995 Jan; 73(1):94-100. PubMed ID: 7740503
[TBL] [Abstract][Full Text] [Related]
7. Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
Vijaykumar D; Sprengeler PA; Shaghafi M; Spencer JR; Katz BA; Yu C; Rai R; Young WB; Schultz B; Janc J
Bioorg Med Chem Lett; 2006 May; 16(10):2796-9. PubMed ID: 16487703
[TBL] [Abstract][Full Text] [Related]
8. Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C.
Bode W; Brandstetter H; Mather T; Stubbs MT
Thromb Haemost; 1997 Jul; 78(1):501-11. PubMed ID: 9198204
[No Abstract] [Full Text] [Related]
9. Relative efficacy of active site-blocked factors IXa, Xa in models of rabbit venous and arterio-venous thrombosis.
Wong AG; Gunn AC; Ku P; Hollenbach SJ; Sinha U
Thromb Haemost; 1997 Jun; 77(6):1143-7. PubMed ID: 9241747
[TBL] [Abstract][Full Text] [Related]
10. Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa.
Izaguirre G; Rezaie AR; Olson ST
J Biol Chem; 2009 Jan; 284(3):1550-8. PubMed ID: 19010776
[TBL] [Abstract][Full Text] [Related]
11. Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.
Wang S; Beck R; Blench T; Burd A; Buxton S; Malic M; Ayele T; Shaikh S; Chahwala S; Chander C; Holland R; Merette S; Zhao L; Blackney M; Watts A
J Med Chem; 2010 Feb; 53(4):1465-72. PubMed ID: 20121198
[TBL] [Abstract][Full Text] [Related]
12. From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3.
Dönnecke D; Schweinitz A; Stürzebecher A; Steinmetzer P; Schuster M; Stürzebecher U; Nicklisch S; Stürzebecher J; Steinmetzer T
Bioorg Med Chem Lett; 2007 Jun; 17(12):3322-9. PubMed ID: 17462889
[TBL] [Abstract][Full Text] [Related]
13. The Na+ binding channel of human coagulation proteases: novel insights on the structure and allosteric modulation revealed by molecular surface analysis.
Silva FP; Antunes OA; de Alencastro RB; De Simone SG
Biophys Chem; 2006 Feb; 119(3):282-94. PubMed ID: 16288954
[TBL] [Abstract][Full Text] [Related]
14. 7-fluoroindazoles as potent and selective inhibitors of factor Xa.
Lee YK; Parks DJ; Lu T; Thieu TV; Markotan T; Pan W; McComsey DF; Milkiewicz KL; Crysler CS; Ninan N; Abad MC; Giardino EC; Maryanoff BE; Damiano BP; Player MR
J Med Chem; 2008 Jan; 51(2):282-97. PubMed ID: 18159923
[TBL] [Abstract][Full Text] [Related]
15. The influence of sodium ion binding on factor IXa activity.
Gopalakrishna K; Rezaie AR
Thromb Haemost; 2006 Jun; 95(6):936-41. PubMed ID: 16732371
[TBL] [Abstract][Full Text] [Related]
16. Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library.
Sagi K; Fujita K; Sugiki M; Takahashi M; Takehana S; Tashiro K; Kayahara T; Yamanashi M; Fukuda Y; Oono S; Okajima A; Iwata S; Shoji M; Sakurai K
Bioorg Med Chem; 2005 Mar; 13(5):1487-96. PubMed ID: 15698764
[TBL] [Abstract][Full Text] [Related]
17. Analyses of activity for factor Xa inhibitors based on Monte Carlo simulations.
Ostrovsky D; Udier-Blagović M; Jorgensen WL
J Med Chem; 2003 Dec; 46(26):5691-9. PubMed ID: 14667222
[TBL] [Abstract][Full Text] [Related]
18. Interaction of feedback control and product inhibition in the activation of factor X by factors IXa and VIII.
Jesty J
Haemostasis; 1991; 21(4):208-18. PubMed ID: 1794747
[TBL] [Abstract][Full Text] [Related]
19. Factor IXa inhibitors as novel anticoagulants.
Howard EL; Becker KC; Rusconi CP; Becker RC
Arterioscler Thromb Vasc Biol; 2007 Apr; 27(4):722-7. PubMed ID: 17272750
[TBL] [Abstract][Full Text] [Related]
20. Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity.
Matter H; Nazaré M; Güssregen S; Will DW; Schreuder H; Bauer A; Urmann M; Ritter K; Wagner M; Wehner V
Angew Chem Int Ed Engl; 2009; 48(16):2911-6. PubMed ID: 19294721
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]