209 related articles for article (PubMed ID: 15454219)
1. Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
Yamashita A; Norton EB; Kaplan JA; Niu C; Loganzo F; Hernandez R; Beyer CF; Annable T; Musto S; Discafani C; Zask A; Ayral-Kaloustian S
Bioorg Med Chem Lett; 2004 Nov; 14(21):5317-22. PubMed ID: 15454219
[TBL] [Abstract][Full Text] [Related]
2. Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.
Niu C; Smith D; Zask A; Loganzo F; Discafani C; Beyer C; Greenberger L; Ayral-Kaloustian S
Bioorg Med Chem Lett; 2004 Aug; 14(16):4329-32. PubMed ID: 15261296
[TBL] [Abstract][Full Text] [Related]
3. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
Loganzo F; Discafani CM; Annable T; Beyer C; Musto S; Hari M; Tan X; Hardy C; Hernandez R; Baxter M; Singanallore T; Khafizova G; Poruchynsky MS; Fojo T; Nieman JA; Ayral-Kaloustian S; Zask A; Andersen RJ; Greenberger LM
Cancer Res; 2003 Apr; 63(8):1838-45. PubMed ID: 12702571
[TBL] [Abstract][Full Text] [Related]
4. Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Chen K; Kuo SC; Hsieh MC; Mauger A; Lin CM; Hamel E; Lee KH
J Med Chem; 1997 Jul; 40(14):2266-75. PubMed ID: 9216846
[TBL] [Abstract][Full Text] [Related]
5. Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents.
Zask A; Kaplan J; Musto S; Loganzo F
J Am Chem Soc; 2005 Dec; 127(50):17667-71. PubMed ID: 16351096
[TBL] [Abstract][Full Text] [Related]
6. 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Zuse A; Schmidt P; Baasner S; Böhm KJ; Müller K; Gerlach M; Günther EG; Unger E; Prinz H
J Med Chem; 2006 Dec; 49(26):7816-25. PubMed ID: 17181164
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
Shibue T; Okamoto I; Morita N; Morita H; Hirasawa Y; Hosoya T; Tamura O
Bioorg Med Chem Lett; 2011 Jan; 21(1):431-4. PubMed ID: 21106374
[TBL] [Abstract][Full Text] [Related]
8. D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.
Zask A; Birnberg G; Cheung K; Kaplan J; Niu C; Norton E; Yamashita A; Beyer C; Krishnamurthy G; Greenberger LM; Loganzo F; Ayral-Kaloustian S
Bioorg Med Chem Lett; 2004 Aug; 14(16):4353-8. PubMed ID: 15261301
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
Romagnoli R; Baraldi PG; Pavani MG; Tabrizi MA; Preti D; Fruttarolo F; Piccagli L; Jung MK; Hamel E; Borgatti M; Gambari R
J Med Chem; 2006 Jun; 49(13):3906-15. PubMed ID: 16789746
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
Romagnoli R; Baraldi PG; Carrion MD; Cara CL; Cruz-Lopez O; Preti D; Tolomeo M; Grimaudo S; Di Cristina A; Zonta N; Balzarini J; Brancale A; Sarkar T; Hamel E
Bioorg Med Chem; 2008 May; 16(10):5367-76. PubMed ID: 18440234
[TBL] [Abstract][Full Text] [Related]
11. Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Prinz H; Ishii Y; Hirano T; Stoiber T; Camacho Gomez JA; Schmidt P; Düssmann H; Burger AM; Prehn JH; Günther EG; Unger E; Umezawa K
J Med Chem; 2003 Jul; 46(15):3382-94. PubMed ID: 12852768
[TBL] [Abstract][Full Text] [Related]
12. 4- and 5-aroylindoles as novel classes of potent antitubulin agents.
Liou JP; Wu CY; Hsieh HP; Chang CY; Chen CM; Kuo CC; Chang JY
J Med Chem; 2007 Sep; 50(18):4548-52. PubMed ID: 17685504
[TBL] [Abstract][Full Text] [Related]
13. Identification of novel and improved antimitotic agents derived from noscapine.
Anderson JT; Ting AE; Boozer S; Brunden KR; Crumrine C; Danzig J; Dent T; Faga L; Harrington JJ; Hodnick WF; Murphy SM; Pawlowski G; Perry R; Raber A; Rundlett SE; Stricker-Krongrad A; Wang J; Bennani YL
J Med Chem; 2005 Nov; 48(23):7096-8. PubMed ID: 16279766
[TBL] [Abstract][Full Text] [Related]
14. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
Pettit GR; Rhodes MR; Herald DL; Hamel E; Schmidt JM; Pettit RK
J Med Chem; 2005 Jun; 48(12):4087-99. PubMed ID: 15943482
[TBL] [Abstract][Full Text] [Related]
15. Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.
Edsall AB; Mohanakrishnan AK; Yang D; Fanwick PE; Hamel E; Hanson AD; Agoston GE; Cushman M
J Med Chem; 2004 Oct; 47(21):5126-39. PubMed ID: 15456256
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Pfeiffer B; Hauenstein K; Merz P; Gertsch J; Altmann KH
Bioorg Med Chem Lett; 2009 Jul; 19(14):3760-3. PubMed ID: 19433359
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues.
Nieman JA; Coleman JE; Wallace DJ; Piers E; Lim LY; Roberge M; Andersen RJ
J Nat Prod; 2003 Feb; 66(2):183-99. PubMed ID: 12608848
[TBL] [Abstract][Full Text] [Related]
18. Arylthioindoles, potent inhibitors of tubulin polymerization.
De Martino G; La Regina G; Coluccia A; Edler MC; Barbera MC; Brancale A; Wilcox E; Hamel E; Artico M; Silvestri R
J Med Chem; 2004 Dec; 47(25):6120-3. PubMed ID: 15566282
[TBL] [Abstract][Full Text] [Related]
19. Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.
Gastpar R; Goldbrunner M; Marko D; von Angerer E
J Med Chem; 1998 Dec; 41(25):4965-72. PubMed ID: 9836614
[TBL] [Abstract][Full Text] [Related]
20. Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin.
Hadaschik BA; Adomat H; Fazli L; Fradet Y; Andersen RJ; Gleave ME; So AI
Clin Cancer Res; 2008 Mar; 14(5):1510-8. PubMed ID: 18316576
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
