These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 15454221)

  • 1. Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.
    Pinkerton AB; Cube RV; Hutchinson JH; Rowe BA; Schaffhauser H; Zhao X; Daggett LP; Vernier JM
    Bioorg Med Chem Lett; 2004 Nov; 14(21):5329-32. PubMed ID: 15454221
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.
    Pinkerton AB; Cube RV; Hutchinson JH; James JK; Gardner MF; Schaffhauser H; Rowe BA; Daggett LP; Vernier JM
    Bioorg Med Chem Lett; 2004 Dec; 14(23):5867-72. PubMed ID: 15501058
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
    Pinkerton AB; Cube RV; Hutchinson JH; James JK; Gardner MF; Rowe BA; Schaffhauser H; Rodriguez DE; Campbell UC; Daggett LP; Vernier JM
    Bioorg Med Chem Lett; 2005 Mar; 15(6):1565-71. PubMed ID: 15745798
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.
    Pinkerton AB; Vernier JM; Schaffhauser H; Rowe BA; Campbell UC; Rodriguez DE; Lorrain DS; Baccei CS; Daggett LP; Bristow LJ
    J Med Chem; 2004 Aug; 47(18):4595-9. PubMed ID: 15317469
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.
    Govek SP; Bonnefous C; Hutchinson JH; Kamenecka T; McQuiston J; Pracitto R; Zhao LX; Gardner MF; James JK; Daggett LP; Rowe BA; Schaffhauser H; Bristow LJ; Campbell UC; Rodriguez DE; Vernier JM
    Bioorg Med Chem Lett; 2005 Sep; 15(18):4068-72. PubMed ID: 16005222
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.
    Bonnefous C; Vernier JM; Hutchinson JH; Gardner MF; Cramer M; James JK; Rowe BA; Daggett LP; Schaffhauser H; Kamenecka TM
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4354-8. PubMed ID: 16046122
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.
    Johnson MP; Baez M; Jagdmann GE; Britton TC; Large TH; Callagaro DO; Tizzano JP; Monn JA; Schoepp DD
    J Med Chem; 2003 Jul; 46(15):3189-92. PubMed ID: 12852748
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide.
    Barda DA; Wang ZQ; Britton TC; Henry SS; Jagdmann GE; Coleman DS; Johnson MP; Andis SL; Schoepp DD
    Bioorg Med Chem Lett; 2004 Jun; 14(12):3099-102. PubMed ID: 15149652
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.
    Johnson MP; Nisenbaum ES; Large TH; Emkey R; Baez M; Kingston AE
    Biochem Soc Trans; 2004 Nov; 32(Pt 5):881-7. PubMed ID: 15494040
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.
    Wágner G; Wéber C; Nyéki O; Nógrádi K; Bielik A; Molnár L; Bobok A; Horváth A; Kiss B; Kolok S; Nagy J; Kurkó D; Gál K; Greiner I; Szombathelyi Z; Keseru GM; Domány G
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3737-41. PubMed ID: 20483612
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
    Poon SF; Eastman BW; Chapman DF; Chung J; Cramer M; Holtz G; Cosford ND; Smith ND
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5477-80. PubMed ID: 15482907
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.
    Vieira E; Huwyler J; Jolidon S; Knoflach F; Mutel V; Wichmann J
    Bioorg Med Chem Lett; 2005 Oct; 15(20):4628-31. PubMed ID: 16099654
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
    Lindsley CW; Wisnoski DD; Leister WH; O'brien JA; Lemaire W; Williams DL; Burno M; Sur C; Kinney GG; Pettibone DJ; Tiller PR; Smith S; Duggan ME; Hartman GD; Conn PJ; Huff JR
    J Med Chem; 2004 Nov; 47(24):5825-8. PubMed ID: 15537338
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.
    Hu E; Chua PC; Tehrani L; Nagasawa JY; Pinkerton AB; Rowe BA; Vernier JM; Hutchinson JH; Cosford ND
    Bioorg Med Chem Lett; 2004 Oct; 14(20):5071-4. PubMed ID: 15380201
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
    Ritzén A; Sindet R; Hentzer M; Svendsen N; Brodbeck RM; Bundgaard C
    Bioorg Med Chem Lett; 2009 Jun; 19(12):3275-8. PubMed ID: 19443216
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.
    Smith ND; Poon SF; Huang D; Green M; King C; Tehrani L; Roppe JR; Chung J; Chapman DP; Cramer M; Cosford ND
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5481-4. PubMed ID: 15482908
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).
    Cube RV; Vernier JM; Hutchinson JH; Gardner MF; James JK; Rowe BA; Schaffhauser H; Daggett L; Pinkerton AB
    Bioorg Med Chem Lett; 2005 May; 15(9):2389-93. PubMed ID: 15837331
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Progress in the developement of positive allosteric modulators of the metabotropic glutamate receptor 2.
    Trabanco AA; Cid JM; Lavreysen H; Macdonald GJ; Tresadern G
    Curr Med Chem; 2011; 18(1):47-68. PubMed ID: 21110815
    [TBL] [Abstract][Full Text] [Related]  

  • 19. New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.
    Trabanco AA; Duvey G; Cid JM; Macdonald GJ; Cluzeau P; Nhem V; Furnari R; Behaj N; Poulain G; Finn T; Lavreysen H; Poli S; Raux A; Thollon Y; Poirier N; D'Addona D; Andrés JI; Lutjens R; Le Poul E; Imogai H; Rocher JP
    Bioorg Med Chem Lett; 2011 Feb; 21(3):971-6. PubMed ID: 21232953
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
    Zhao Z; Wisnoski DD; O'Brien JA; Lemaire W; Williams DL; Jacobson MA; Wittman M; Ha SN; Schaffhauser H; Sur C; Pettibone DJ; Duggan ME; Conn PJ; Hartman GD; Lindsley CW
    Bioorg Med Chem Lett; 2007 Mar; 17(5):1386-91. PubMed ID: 17210250
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.