These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 15454221)

  • 21. 3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
    Tehrani LR; Smith ND; Huang D; Poon SF; Roppe JR; Seiders TJ; Chapman DF; Chung J; Cramer M; Cosford ND
    Bioorg Med Chem Lett; 2005 Nov; 15(22):5061-4. PubMed ID: 16183275
    [TBL] [Abstract][Full Text] [Related]  

  • 22. 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
    Brnardic EJ; Fraley ME; Garbaccio RM; Layton ME; Sanders JM; Culberson C; Jacobson MA; Magliaro BC; Hutson PH; O'Brien JA; Huszar SL; Uslaner JM; Fillgrove KL; Tang C; Kuo Y; Sur SM; Hartman GD
    Bioorg Med Chem Lett; 2010 May; 20(10):3129-33. PubMed ID: 20409708
    [TBL] [Abstract][Full Text] [Related]  

  • 23. 2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
    Huang D; Poon SF; Chapman DF; Chung J; Cramer M; Reger TS; Roppe JR; Tehrani L; Cosford ND; Smith ND
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5473-6. PubMed ID: 15482906
    [TBL] [Abstract][Full Text] [Related]  

  • 24. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
    Chen Y; Goudet C; Pin JP; Conn PJ
    Mol Pharmacol; 2008 Mar; 73(3):909-18. PubMed ID: 18056795
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
    Tresadern G; Cid JM; Macdonald GJ; Vega JA; de Lucas AI; García A; Matesanz E; Linares ML; Oehlrich D; Lavreysen H; Biesmans I; Trabanco AA
    Bioorg Med Chem Lett; 2010 Jan; 20(1):175-9. PubMed ID: 19932615
    [TBL] [Abstract][Full Text] [Related]  

  • 26. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
    Liu F; Grauer S; Kelley C; Navarra R; Graf R; Zhang G; Atkinson PJ; Popiolek M; Wantuch C; Khawaja X; Smith D; Olsen M; Kouranova E; Lai M; Pruthi F; Pulicicchio C; Day M; Gilbert A; Pausch MH; Brandon NJ; Beyer CE; Comery TA; Logue S; Rosenzweig-Lipson S; Marquis KL
    J Pharmacol Exp Ther; 2008 Dec; 327(3):827-39. PubMed ID: 18753411
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia.
    Fraley ME
    Expert Opin Ther Pat; 2009 Sep; 19(9):1259-75. PubMed ID: 19552508
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.
    Blanco MJ; Benesh DR; Knobelsdorf JA; Khilevich A; Cortez GS; Mokube F; Aicher TD; Groendyke TM; Marmsater FP; Tang TP; Johnson KW; Clemens-Smith A; Muhlhauser MA; Swanson S; Catlow J; Emkey R; Johnson MP; Schkeryantz JM
    Bioorg Med Chem Lett; 2017 Jan; 27(2):323-328. PubMed ID: 27908761
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site.
    Rowe BA; Schaffhauser H; Morales S; Lubbers LS; Bonnefous C; Kamenecka TM; McQuiston J; Daggett LP
    J Pharmacol Exp Ther; 2008 Jul; 326(1):240-51. PubMed ID: 18430863
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.
    Layton ME; Reif AJ; Hartingh TJ; Rodzinak K; Dudkin V; Wang C; Arrington K; Kelly MJ; Garbaccio RM; O'Brien JA; Magliaro BC; Uslaner JM; Huszar SL; Fillgrove KL; Tang C; Kuo Y; Jacobson MA
    Bioorg Med Chem Lett; 2016 Feb; 26(4):1260-4. PubMed ID: 26810316
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators.
    Schann S; Mayer S; Franchet C; Frauli M; Steinberg E; Thomas M; Baron L; Neuville P
    J Med Chem; 2010 Dec; 53(24):8775-9. PubMed ID: 21105727
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.
    Nakamura M; Kurihara H; Suzuki G; Mitsuya M; Ohkubo M; Ohta H
    Bioorg Med Chem Lett; 2010 Jan; 20(2):726-9. PubMed ID: 20005101
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
    Galici R; Jones CK; Hemstapat K; Nong Y; Echemendia NG; Williams LC; de Paulis T; Conn PJ
    J Pharmacol Exp Ther; 2006 Jul; 318(1):173-85. PubMed ID: 16608916
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
    Varnes JG; Marcus AP; Mauger RC; Throner SR; Hoesch V; King MM; Wang X; Sygowski LA; Spear N; Gadient R; Brown DG; Campbell JB
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1402-6. PubMed ID: 21295468
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide].
    Satow A; Maehara S; Ise S; Hikichi H; Fukushima M; Suzuki G; Kimura T; Tanak T; Ito S; Kawamoto H; Ohta H
    J Pharmacol Exp Ther; 2008 Aug; 326(2):577-86. PubMed ID: 18487514
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
    de Paulis T; Hemstapat K; Chen Y; Zhang Y; Saleh S; Alagille D; Baldwin RM; Tamagnan GD; Conn PJ
    J Med Chem; 2006 Jun; 49(11):3332-44. PubMed ID: 16722652
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.
    Kubas H; Meyer U; Krueger B; Hechenberger M; Vanejevs M; Zemribo R; Kauss V; Ambartsumova R; Pyatkin I; Polosukhin AI; Abel U
    Bioorg Med Chem Lett; 2013 Aug; 23(16):4493-500. PubMed ID: 23856046
    [TBL] [Abstract][Full Text] [Related]  

  • 38. N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators.
    Packiarajan M; Mazza Ferreira CG; Hong SP; White AD; Chandrasena G; Pu X; Brodbeck RM; Robichaud AJ
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5658-62. PubMed ID: 22832311
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.
    Zhang Y; Rodriguez AL; Conn PJ
    J Pharmacol Exp Ther; 2005 Dec; 315(3):1212-9. PubMed ID: 16135701
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.
    Noeske T; Trifanova D; Kauss V; Renner S; Parsons CG; Schneider G; Weil T
    Bioorg Med Chem; 2009 Aug; 17(15):5708-15. PubMed ID: 19574055
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.