BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

335 related articles for article (PubMed ID: 15456269)

  • 1. Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects.
    Wnuk SF; Lewandowska E; Sacasa PR; Crain LN; Zhang J; Borchardt RT; De Clercq E
    J Med Chem; 2004 Oct; 47(21):5251-7. PubMed ID: 15456269
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects.
    Wnuk SF; Ro BO; Valdez CA; Lewandowska E; Valdez NX; Sacasa PR; Yin D; Zhang J; Borchardt RT; De Clercq E
    J Med Chem; 2002 Jun; 45(12):2651-8. PubMed ID: 12036374
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine).
    Robins MJ; Wnuk SF; Yang X; Yuan CS; Borchardt RT; Balzarini J; De Clercq E
    J Med Chem; 1998 Sep; 41(20):3857-64. PubMed ID: 9748360
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
    Wnuk SF; Yuan CS; Borchardt RT; Balzarini J; De Clercq E; Robins MJ
    J Med Chem; 1997 May; 40(11):1608-18. PubMed ID: 9171871
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
    Zhou S; Breitenbach JM; Borysko KZ; Drach JC; Kern ER; Gullen E; Cheng YC; Zemlicka J
    J Med Chem; 2004 Jan; 47(3):566-75. PubMed ID: 14736238
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Doubly homologated dihalovinyl and acetylene analogues of adenosine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects.
    Wnuk SF; Valdez CA; Khan J; Moutinho P; Robins MJ; Yang X; Borchardt RT; Balzarini J; De Clercq E
    J Med Chem; 2000 Mar; 43(6):1180-6. PubMed ID: 10737751
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects.
    Guillerm G; Muzard M; Glapski C; Pilard S; De Clercq E
    J Med Chem; 2006 Feb; 49(4):1223-6. PubMed ID: 16480257
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Are L-adenosine and its derivatives substrates for S-adenosyl-L-homocysteine hydrolase?
    Wang M; Zhang J; Andrei D; Kuczera K; Borchardt RT; Wnuk SF
    J Med Chem; 2005 May; 48(10):3649-53. PubMed ID: 15887973
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition.
    Wnuk SF; Yuan CS; Borchardt RT; Balzarini J; De Clercq E; Robins MJ
    J Med Chem; 1994 Oct; 37(21):3579-87. PubMed ID: 7932585
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 4'-Fluorinated carbocyclic nucleosides: synthesis and inhibitory activity against S-adenosyl-L-homocysteine hydrolase.
    Kitade Y; Ando T; Yamaguchi T; Hori A; Nakanishi M; Ueno Y
    Bioorg Med Chem; 2006 Aug; 14(16):5578-83. PubMed ID: 16682206
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aristeromycin-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase.
    Liu S; Yuan CS; Borchardt RT
    J Med Chem; 1996 Jun; 39(12):2347-53. PubMed ID: 8691429
    [TBL] [Abstract][Full Text] [Related]  

  • 12. (Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
    Qiu YL; Ksebati MB; Ptak RG; Fan BY; Breitenbach JM; Lin JS; Cheng YC; Kern ER; Drach JC; Zemlicka J
    J Med Chem; 1998 Jan; 41(1):10-23. PubMed ID: 9438017
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine.
    Wnuk SF; Mao Y; Yuan CS; Borchardt RT; Andrei G; Balzarini J; De Clercq E; Robins MJ
    J Med Chem; 1998 Jul; 41(16):3078-83. PubMed ID: 9685247
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
    Robins MJ; Nowak I; Rajwanshi VK; Miranda K; Cannon JF; Peterson MA; Andrei G; Snoeck R; De Clercq E; Balzarini J
    J Med Chem; 2007 Aug; 50(16):3897-905. PubMed ID: 17622128
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides.
    Qin X; Chen X; Wang K; Polin L; Kern ER; Drach JC; Gullen E; Cheng YC; Zemlicka J
    Bioorg Med Chem; 2006 Feb; 14(4):1247-54. PubMed ID: 16242337
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Stereocontrolled synthesis of diene and enyne sugar-modified nucleosides and their interaction with S-adenosyl-L-homocysteine hydrolase.
    Wnuk SF; Sacasa PR; Crain LN; Lewandowska E; Zhang J; Borchardt RT
    Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):783-5. PubMed ID: 14565278
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, antiviral and cytostatic activities, of carbocyclic nucleosides incorporating a modified cyclopentane ring. IV. Adenosine and uridine analogues.
    Nieto MI; Caamaño O; Fernández F; Gómez M; Balzarini J; De Clercq E
    Nucleosides Nucleotides Nucleic Acids; 2002; 21(3):243-55. PubMed ID: 11991165
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A.
    Shuto S; Obara T; Saito Y; Yamashita K; Tanaka M; Sasaki T; Andrei G; Snoeck R; Neyts J; Padalko E; Balzarini J; De Clercq E; Matsuda A
    Chem Pharm Bull (Tokyo); 1997 Jul; 45(7):1163-8. PubMed ID: 9246750
    [TBL] [Abstract][Full Text] [Related]  

  • 19. New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.
    Obara T; Shuto S; Saito Y; Snoeck R; Andrei G; Balzarini J; De Clercq E; Matsuda A
    J Med Chem; 1996 Sep; 39(19):3847-52. PubMed ID: 8809173
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effects of 4'-modified analogs of aristeromycin on the metabolism of S-adenosyl-L-homocysteine in murine L929 cells.
    Ault-Riché DB; Lee Y; Yuan CS; Hasobe M; Wolfe MS; Borcherding DR; Borchardt RT
    Mol Pharmacol; 1993 Jun; 43(6):989-97. PubMed ID: 8316227
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.