BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

535 related articles for article (PubMed ID: 15456764)

  • 1. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
    Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
    J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
    Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
    J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.
    Hansson CA; Popescu BO; Laudon H; Cedazo-Minguez A; Popescu LM; Winblad B; Ankarcrona M
    J Neurochem; 2006 Apr; 97(2):356-64. PubMed ID: 16539675
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T; Ma G; Cai H; Price DL; Wong PC
    J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
    Kim SH; Yin YI; Li YM; Sisodia SS
    J Biol Chem; 2004 Nov; 279(47):48615-9. PubMed ID: 15456788
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
    Kim SH; Ikeuchi T; Yu C; Sisodia SS
    J Biol Chem; 2003 Sep; 278(36):33992-4002. PubMed ID: 12821663
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
    Zhang L; Lee J; Song L; Sun X; Shen J; Terracina G; Parker EM
    Biochemistry; 2005 Mar; 44(11):4450-7. PubMed ID: 15766275
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.
    Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; Greengard P; Xu H
    J Biol Chem; 2004 Sep; 279(39):40560-6. PubMed ID: 15247291
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Gamma-secretase complex assembly within the early secretory pathway.
    Capell A; Beher D; Prokop S; Steiner H; Kaether C; Shearman MS; Haass C
    J Biol Chem; 2005 Feb; 280(8):6471-8. PubMed ID: 15591316
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.
    Vetrivel KS; Cheng H; Lin W; Sakurai T; Li T; Nukina N; Wong PC; Xu H; Thinakaran G
    J Biol Chem; 2004 Oct; 279(43):44945-54. PubMed ID: 15322084
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.
    Mamada N; Tanokashira D; Ishii K; Tamaoka A; Araki W
    Biochem Biophys Res Commun; 2017 Apr; 486(2):321-328. PubMed ID: 28302486
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
    Pasternak SH; Bagshaw RD; Guiral M; Zhang S; Ackerley CA; Pak BJ; Callahan JW; Mahuran DJ
    J Biol Chem; 2003 Jul; 278(29):26687-94. PubMed ID: 12736250
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
    Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
    Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
    Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
    De Strooper B
    Neuron; 2003 Apr; 38(1):9-12. PubMed ID: 12691659
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
    Chyung JH; Raper DM; Selkoe DJ
    J Biol Chem; 2005 Feb; 280(6):4383-92. PubMed ID: 15569674
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
    Sudoh S; Hua G; Kawamura Y; Maruyama K; Komano H; Yanagisawa K
    Eur J Biochem; 2000 Apr; 267(7):2036-45. PubMed ID: 10727943
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
    Steiner H; Winkler E; Edbauer D; Prokop S; Basset G; Yamasaki A; Kostka M; Haass C
    J Biol Chem; 2002 Oct; 277(42):39062-5. PubMed ID: 12198112
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
    Periz G; Fortini ME
    J Neurosci Res; 2004 Aug; 77(3):309-22. PubMed ID: 15248287
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.