186 related articles for article (PubMed ID: 15467762)
1. The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.
Bhonde MR; Hanski ML; Magrini R; Moorthy D; Müller A; Sausville EA; Kohno K; Wiegand P; Daniel PT; Zeitz M; Hanski C
Oncogene; 2005 Jan; 24(1):148-56. PubMed ID: 15467762
[TBL] [Abstract][Full Text] [Related]
2. Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
Sugiyama K; Akiyama T; Shimizu M; Tamaoki T; Courage C; Gescher A; Akinaga S
Cancer Res; 1999 Sep; 59(17):4406-12. PubMed ID: 10485490
[TBL] [Abstract][Full Text] [Related]
3. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
Akiyama T; Yoshida T; Tsujita T; Shimizu M; Mizukami T; Okabe M; Akinaga S
Cancer Res; 1997 Apr; 57(8):1495-501. PubMed ID: 9108451
[TBL] [Abstract][Full Text] [Related]
4. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway.
Facchinetti MM; De Siervi A; Toskos D; Senderowicz AM
Cancer Res; 2004 May; 64(10):3629-37. PubMed ID: 15150122
[TBL] [Abstract][Full Text] [Related]
5. 7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.
Cartee L; Sankala H; Davis C; Smith R; Maggio S; Lin PS; Dent P; Grant S
Int J Oncol; 2002 Aug; 21(2):351-9. PubMed ID: 12118331
[TBL] [Abstract][Full Text] [Related]
6. Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
Patel V; Lahusen T; Leethanakul C; Igishi T; Kremer M; Quintanilla-Martinez L; Ensley JF; Sausville EA; Gutkind JS; Senderowicz AM
Clin Cancer Res; 2002 Nov; 8(11):3549-60. PubMed ID: 12429646
[TBL] [Abstract][Full Text] [Related]
7. Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
Manns J; Daubrawa M; Driessen S; Paasch F; Hoffmann N; Löffler A; Lauber K; Dieterle A; Alers S; Iftner T; Schulze-Osthoff K; Stork B; Wesselborg S
FASEB J; 2011 Sep; 25(9):3250-61. PubMed ID: 21659556
[TBL] [Abstract][Full Text] [Related]
8. Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
McMasters RA; Wilbert TN; Jones KE; Pitlyk K; Saylors RL; Moyer MP; Chambers TC; Drake RR
Cancer Gene Ther; 2000 Apr; 7(4):563-73. PubMed ID: 10811474
[TBL] [Abstract][Full Text] [Related]
9. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells.
Real PJ; Sierra A; De Juan A; Segovia JC; Lopez-Vega JM; Fernandez-Luna JL
Oncogene; 2002 Oct; 21(50):7611-8. PubMed ID: 12400004
[TBL] [Abstract][Full Text] [Related]
10. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
Dai Y; Dent P; Grant S
Mol Pharmacol; 2003 Dec; 64(6):1402-9. PubMed ID: 14645670
[TBL] [Abstract][Full Text] [Related]
11. Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL.
Chan UP; Lee JF; Wang SH; Leung KL; Chen GG
Anticancer Drugs; 2003 Oct; 14(9):761-6. PubMed ID: 14551511
[TBL] [Abstract][Full Text] [Related]
12. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
Chinni SR; Li Y; Upadhyay S; Koppolu PK; Sarkar FH
Oncogene; 2001 May; 20(23):2927-36. PubMed ID: 11420705
[TBL] [Abstract][Full Text] [Related]
13. Susceptibility of thyroid cancer cells to 7-hydroxystaurosporine-induced apoptosis correlates with Bcl-2 protein level.
Wang SH; Phelps E; Utsugi S; Baker JR
Thyroid; 2001 Aug; 11(8):725-31. PubMed ID: 11525264
[TBL] [Abstract][Full Text] [Related]
14. Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway.
Sekharam M; Zhao H; Sun M; Fang Q; Zhang Q; Yuan Z; Dan HC; Boulware D; Cheng JQ; Coppola D
Cancer Res; 2003 Nov; 63(22):7708-16. PubMed ID: 14633695
[TBL] [Abstract][Full Text] [Related]
15. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.
Wittmann S; Bali P; Donapaty S; Nimmanapalli R; Guo F; Yamaguchi H; Huang M; Jove R; Wang HG; Bhalla K
Cancer Res; 2003 Jan; 63(1):93-9. PubMed ID: 12517783
[TBL] [Abstract][Full Text] [Related]
16. Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells.
Hasenjäger A; Gillissen B; Müller A; Normand G; Hemmati PG; Schuler M; Dörken B; Daniel PT
Oncogene; 2004 Jun; 23(26):4523-35. PubMed ID: 15064710
[TBL] [Abstract][Full Text] [Related]
17. UCN-01 (7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primary and metastatic oral cancer cell lines in vitro.
Otsubo A; Bhawal UK; Nomura Y; Mitani Y; Ozawa K; Kuniyasu H; Sugiyama M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar; 103(3):391-7. PubMed ID: 17321452
[TBL] [Abstract][Full Text] [Related]
18. 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport.
Kondapaka SB; Zarnowski M; Yver DR; Sausville EA; Cushman SW
Clin Cancer Res; 2004 Nov; 10(21):7192-8. PubMed ID: 15534092
[TBL] [Abstract][Full Text] [Related]
19. The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
Pei XY; Dai Y; Rahmani M; Li W; Dent P; Grant S
Clin Cancer Res; 2005 Jun; 11(12):4589-600. PubMed ID: 15958645
[TBL] [Abstract][Full Text] [Related]
20. 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
Shao RG; Shimizu T; Pommier Y
Exp Cell Res; 1997 Aug; 234(2):388-97. PubMed ID: 9260909
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
