BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

507 related articles for article (PubMed ID: 15468057)

  • 1. PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.
    Seminario MC; Precht P; Bunnell SC; Warren SE; Morris CM; Taub D; Wange RL
    Eur J Immunol; 2004 Nov; 34(11):3165-75. PubMed ID: 15468057
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
    Shan X; Czar MJ; Bunnell SC; Liu P; Liu Y; Schwartzberg PL; Wange RL
    Mol Cell Biol; 2000 Sep; 20(18):6945-57. PubMed ID: 10958690
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
    Freeburn RW; Wright KL; Burgess SJ; Astoul E; Cantrell DA; Ward SG
    J Immunol; 2002 Nov; 169(10):5441-50. PubMed ID: 12421919
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.
    Wang X; Gjörloff-Wingren A; Saxena M; Pathan N; Reed JC; Mustelin T
    J Immunol; 2000 Feb; 164(4):1934-9. PubMed ID: 10657643
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
    Tang X; Powelka AM; Soriano NA; Czech MP; Guilherme A
    J Biol Chem; 2005 Jun; 280(23):22523-9. PubMed ID: 15824124
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.
    St-Germain ME; Gagnon V; Mathieu I; Parent S; Asselin E
    Int J Oncol; 2004 May; 24(5):1311-24. PubMed ID: 15067356
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.
    Zhang J; Choi Y; Mavromatis B; Lichtenstein A; Li W
    Oncogene; 2003 Sep; 22(40):6289-95. PubMed ID: 13679867
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
    Asano T; Yao Y; Zhu J; Li D; Abbruzzese JL; Reddy SA
    Oncogene; 2004 Nov; 23(53):8571-80. PubMed ID: 15467756
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN.
    Seminario MC; Wange RL
    Semin Immunol; 2002 Feb; 14(1):27-36. PubMed ID: 11884228
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
    Ono H; Katagiri H; Funaki M; Anai M; Inukai K; Fukushima Y; Sakoda H; Ogihara T; Onishi Y; Fujishiro M; Kikuchi M; Oka Y; Asano T
    Mol Endocrinol; 2001 Aug; 15(8):1411-22. PubMed ID: 11463863
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing?
    Tsugawa K; Jones MK; Akahoshi T; Moon WS; Maehara Y; Hashizume M; Sarfeh IJ; Tarnawski AS
    FASEB J; 2003 Dec; 17(15):2316-8. PubMed ID: 14525948
    [TBL] [Abstract][Full Text] [Related]  

  • 12. PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.
    Kim S; Domon-Dell C; Wang Q; Chung DH; Di Cristofano A; Pandolfi PP; Freund JN; Evers BM
    Gastroenterology; 2002 Oct; 123(4):1163-78. PubMed ID: 12360479
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.
    Freeley M; Park J; Yang KJ; Wange RL; Volkov Y; Kelleher D; Long A
    Cell Signal; 2007 Dec; 19(12):2444-57. PubMed ID: 17826953
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.
    Goetze S; Bungenstock A; Czupalla C; Eilers F; Stawowy P; Kintscher U; Spencer-Hänsch C; Graf K; Nürnberg B; Law RE; Fleck E; Gräfe M
    Hypertension; 2002 Nov; 40(5):748-54. PubMed ID: 12411472
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mycobacterial antigen(s) induce anergy by altering TCR- and TCR/CD28-induced signalling events: insights into T-cell unresponsiveness in leprosy.
    Dagur PK; Sharma B; Kumar G; Khan NA; Katoch VM; Sengupta U; Joshi B
    Mol Immunol; 2010 Feb; 47(5):943-52. PubMed ID: 20018378
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.
    Wang J; Ouyang W; Li J; Wei L; Ma Q; Zhang Z; Tong Q; He J; Huang C
    Cancer Res; 2005 Aug; 65(15):6601-11. PubMed ID: 16061640
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 70Z/3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism.
    Graham LJ; Verí MC; DeBell KE; Noviello C; Rawat R; Jen S; Bonvini E; Rellahan B
    Oncogene; 2003 Apr; 22(16):2493-503. PubMed ID: 12717426
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.
    Xu Z; Stokoe D; Kane LP; Weiss A
    Cell Growth Differ; 2002 Jul; 13(7):285-96. PubMed ID: 12133897
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
    Choi Y; Zhang J; Murga C; Yu H; Koller E; Monia BP; Gutkind JS; Li W
    Oncogene; 2002 Aug; 21(34):5289-300. PubMed ID: 12149650
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
    Horn S; Endl E; Fehse B; Weck MM; Mayr GW; Jücker M
    Leukemia; 2004 Nov; 18(11):1839-49. PubMed ID: 15457186
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.