These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 15469398)

  • 1. Second annual GPCRs: from orphan to blockbuster.
    Gilchrist A
    Expert Opin Ther Targets; 2004 Oct; 8(5):495-8. PubMed ID: 15469398
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening.
    Eglen RM; Bosse R; Reisine T
    Assay Drug Dev Technol; 2007 Jun; 5(3):425-51. PubMed ID: 17638542
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The future of G protein-coupled receptors as targets in drug discovery.
    Lundstrom K
    IDrugs; 2005 Nov; 8(11):909-13. PubMed ID: 16254784
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets.
    Lee DK; George SR; O'Dowd BF
    Expert Opin Ther Targets; 2002 Apr; 6(2):185-202. PubMed ID: 12223080
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rational Modification of the Biological Profile of GPCR Ligands through Combination with Other Biologically Active Moieties.
    Huang G; Nimczick M; Decker M
    Arch Pharm (Weinheim); 2015 Aug; 348(8):531-40. PubMed ID: 25941009
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allosteric modulation of G protein-coupled receptors.
    May LT; Avlani VA; Sexton PM; Christopoulos A
    Curr Pharm Des; 2004; 10(17):2003-13. PubMed ID: 15279541
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Using silico methods predicting ligands for orphan GPCRs.
    Jiang Z; Zhou Y
    Curr Protein Pept Sci; 2006 Oct; 7(5):459-64. PubMed ID: 17073696
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function.
    Kristiansen K
    Pharmacol Ther; 2004 Jul; 103(1):21-80. PubMed ID: 15251227
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High-Throughput Screening for Allosteric Modulators of GPCRs.
    Bertekap RL; Burford NT; Li Z; Alt A
    Methods Mol Biol; 2015; 1335():223-40. PubMed ID: 26260604
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An ultra-HTS process for the identification of small molecule modulators of orphan G-protein-coupled receptors.
    Cacace A; Banks M; Spicer T; Civoli F; Watson J
    Drug Discov Today; 2003 Sep; 8(17):785-92. PubMed ID: 12946641
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Intracellular Receptor Modulation: Novel Approach to Target GPCRs.
    Ortiz Zacarías NV; Lenselink EB; IJzerman AP; Handel TM; Heitman LH
    Trends Pharmacol Sci; 2018 Jun; 39(6):547-559. PubMed ID: 29653834
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Allosteric inhibition of g-protein coupled receptor oligomerization: strategies and challenges for drug development.
    Hurevich M; Talhami A; Shalev DE; Gilon C
    Curr Top Med Chem; 2014; 14(15):1842-63. PubMed ID: 25175995
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synoptic pharmacology: Detecting and assessing the pharmacological significance of ligands for orphan receptors.
    Kenakin TP
    Pharmacol Res; 2016 Dec; 114():284-290. PubMed ID: 26804250
    [TBL] [Abstract][Full Text] [Related]  

  • 14. From purified GPCRs to drug discovery: the promise of protein-based methodologies.
    Alkhalfioui F; Magnin T; Wagner R
    Curr Opin Pharmacol; 2009 Oct; 9(5):629-35. PubMed ID: 19443270
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of signal transduction pathways used by orphan g protein-coupled receptors.
    Bresnick JN; Skynner HA; Chapman KL; Jack AD; Zamiara E; Negulescu P; Beaumont K; Patel S; McAllister G
    Assay Drug Dev Technol; 2003 Apr; 1(2):239-49. PubMed ID: 15090189
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alternative drug discovery approaches for orphan GPCRs.
    Levoye A; Jockers R
    Drug Discov Today; 2008 Jan; 13(1-2):52-8. PubMed ID: 18190864
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs.
    Bartuzi D; Kaczor AA; Matosiuk D
    Methods Mol Biol; 2018; 1705():297-319. PubMed ID: 29188568
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of new GPCR ligands to illuminate new biology.
    Roth BL; Irwin JJ; Shoichet BK
    Nat Chem Biol; 2017 Nov; 13(11):1143-1151. PubMed ID: 29045379
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders.
    Lütjens R; Rocher JP
    Curr Opin Pharmacol; 2017 Feb; 32():91-95. PubMed ID: 28135635
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Computational methods for studying G protein-coupled receptors (GPCRs).
    Kaczor AA; Rutkowska E; Bartuzi D; Targowska-Duda KM; Matosiuk D; Selent J
    Methods Cell Biol; 2016; 132():359-99. PubMed ID: 26928552
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.