BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

312 related articles for article (PubMed ID: 15491144)

  • 1. Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance.
    Protasevich II; Brouillette CG; Snow ME; Dunham S; Rubin JR; Gogliotti R; Siegel K
    Biochemistry; 2004 Oct; 43(42):13380-9. PubMed ID: 15491144
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.
    Sivaraman S; Zwahlen J; Bell AF; Hedstrom L; Tonge PJ
    Biochemistry; 2003 Apr; 42(15):4406-13. PubMed ID: 12693936
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase.
    Levy CW; Baldock C; Wallace AJ; Sedelnikova S; Viner RC; Clough JM; Stuitje AR; Slabas AR; Rice DW; Rafferty JB
    J Mol Biol; 2001 May; 309(1):171-80. PubMed ID: 11491286
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors.
    Kapoor M; Dar MJ; Surolia A; Surolia N
    Biochem Biophys Res Commun; 2001 Dec; 289(4):832-7. PubMed ID: 11735121
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.
    Seefeld MA; Miller WH; Newlander KA; Burgess WJ; DeWolf WE; Elkins PA; Head MS; Jakas DR; Janson CA; Keller PM; Manley PJ; Moore TD; Payne DJ; Pearson S; Polizzi BJ; Qiu X; Rittenhouse SF; Uzinskas IN; Wallis NG; Huffman WF
    J Med Chem; 2003 Apr; 46(9):1627-35. PubMed ID: 12699381
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The X-ray structure of Escherichia coli enoyl reductase with bound NAD+ at 2.1 A resolution.
    Baldock C; Rafferty JB; Stuitje AR; Slabas AR; Rice DW
    J Mol Biol; 1998 Dec; 284(5):1529-46. PubMed ID: 9878369
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.
    Lu H; Tonge PJ
    Acc Chem Res; 2008 Jan; 41(1):11-20. PubMed ID: 18193820
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene.
    Marcinkeviciene J; Jiang W; Kopcho LM; Locke G; Luo Y; Copeland RA
    Arch Biochem Biophys; 2001 Jun; 390(1):101-8. PubMed ID: 11368521
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA.
    Bergler H; Fuchsbichler S; Högenauer G; Turnowsky F
    Eur J Biochem; 1996 Dec; 242(3):689-94. PubMed ID: 9022698
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues.
    Sivaraman S; Sullivan TJ; Johnson F; Novichenok P; Cui G; Simmerling C; Tonge PJ
    J Med Chem; 2004 Jan; 47(3):509-18. PubMed ID: 14736233
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK.
    Kitagawa H; Ozawa T; Takahata S; Iida M; Saito J; Yamada M
    J Med Chem; 2007 Sep; 50(19):4710-20. PubMed ID: 17713898
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers.
    Yao J; Zhang Q; Min J; He J; Yu Z
    Bioorg Med Chem Lett; 2010 Jan; 20(1):56-9. PubMed ID: 19959361
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI.
    Kitagawa H; Kumura K; Takahata S; Iida M; Atsumi K
    Bioorg Med Chem; 2007 Jan; 15(2):1106-16. PubMed ID: 17095231
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cephalochromin, a FabI-directed antibacterial of microbial origin.
    Zheng CJ; Sohn MJ; Lee S; Hong YS; Kwak JH; Kim WG
    Biochem Biophys Res Commun; 2007 Nov; 362(4):1107-12. PubMed ID: 17825252
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.
    Scapin G; Reddy SG; Zheng R; Blanchard JS
    Biochemistry; 1997 Dec; 36(49):15081-8. PubMed ID: 9398235
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis.
    Oliveira JS; Pereira JH; Canduri F; Rodrigues NC; de Souza ON; de Azevedo WF; Basso LA; Santos DS
    J Mol Biol; 2006 Jun; 359(3):646-66. PubMed ID: 16647717
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystallization and preliminary X-ray diffraction studies of the enoyl-ACP reductase from Escherichia coli.
    Wagner UG; Bergler H; Fuchsbichler S; Turnowsky F; Högenauer G; Kratky C
    J Mol Biol; 1994 Oct; 243(1):126-7. PubMed ID: 7932735
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Exploring the interaction energies for the binding of hydroxydiphenyl ethers to enoyl-acyl carrier protein reductases.
    Muralidharan J; Suguna K; Surolia A; Surolia N
    J Biomol Struct Dyn; 2003 Feb; 20(4):589-94. PubMed ID: 12529157
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.
    Heath RJ; Su N; Murphy CK; Rock CO
    J Biol Chem; 2000 Dec; 275(51):40128-33. PubMed ID: 11007778
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterization of a novel enoyl-acyl carrier protein reductase of diazaborine-resistant Rhodobacter sphaeroides mutant.
    Lee IH; Kim EJ; Cho YH; Lee JK
    Biochem Biophys Res Commun; 2002 Dec; 299(4):621-7. PubMed ID: 12459184
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.