128 related articles for article (PubMed ID: 15508116)
1. Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable.
von Kalle C; Fehse B; Layh-Schmitt G; Schmidt M; Kelly P; Baum C
Semin Hematol; 2004 Oct; 41(4):303-18. PubMed ID: 15508116
[TBL] [Abstract][Full Text] [Related]
2. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.
Hacein-Bey-Abina S; Garrigue A; Wang GP; Soulier J; Lim A; Morillon E; Clappier E; Caccavelli L; Delabesse E; Beldjord K; Asnafi V; MacIntyre E; Dal Cortivo L; Radford I; Brousse N; Sigaux F; Moshous D; Hauer J; Borkhardt A; Belohradsky BH; Wintergerst U; Velez MC; Leiva L; Sorensen R; Wulffraat N; Blanche S; Bushman FD; Fischer A; Cavazzana-Calvo M
J Clin Invest; 2008 Sep; 118(9):3132-42. PubMed ID: 18688285
[TBL] [Abstract][Full Text] [Related]
3. [Development and application of gene therapy technologies].
Ozawa K
Uirusu; 2004 Jun; 54(1):49-57. PubMed ID: 15449904
[TBL] [Abstract][Full Text] [Related]
4. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
Howe SJ; Mansour MR; Schwarzwaelder K; Bartholomae C; Hubank M; Kempski H; Brugman MH; Pike-Overzet K; Chatters SJ; de Ridder D; Gilmour KC; Adams S; Thornhill SI; Parsley KL; Staal FJ; Gale RE; Linch DC; Bayford J; Brown L; Quaye M; Kinnon C; Ancliff P; Webb DK; Schmidt M; von Kalle C; Gaspar HB; Thrasher AJ
J Clin Invest; 2008 Sep; 118(9):3143-50. PubMed ID: 18688286
[TBL] [Abstract][Full Text] [Related]
5. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.
Davé UP; Akagi K; Tripathi R; Cleveland SM; Thompson MA; Yi M; Stephens R; Downing JR; Jenkins NA; Copeland NG
PLoS Genet; 2009 May; 5(5):e1000491. PubMed ID: 19461887
[TBL] [Abstract][Full Text] [Related]
6. For gene therapy, now-quantified risks are deemed troubling.
Twombly R
J Natl Cancer Inst; 2003 Jul; 95(14):1032-3. PubMed ID: 12865444
[No Abstract] [Full Text] [Related]
7. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Hacein-Bey-Abina S; Von Kalle C; Schmidt M; McCormack MP; Wulffraat N; Leboulch P; Lim A; Osborne CS; Pawliuk R; Morillon E; Sorensen R; Forster A; Fraser P; Cohen JI; de Saint Basile G; Alexander I; Wintergerst U; Frebourg T; Aurias A; Stoppa-Lyonnet D; Romana S; Radford-Weiss I; Gross F; Valensi F; Delabesse E; Macintyre E; Sigaux F; Soulier J; Leiva LE; Wissler M; Prinz C; Rabbitts TH; Le Deist F; Fischer A; Cavazzana-Calvo M
Science; 2003 Oct; 302(5644):415-9. PubMed ID: 14564000
[TBL] [Abstract][Full Text] [Related]
8. A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.
Zhou S; Mody D; DeRavin SS; Hauer J; Lu T; Ma Z; Hacein-Bey Abina S; Gray JT; Greene MR; Cavazzana-Calvo M; Malech HL; Sorrentino BP
Blood; 2010 Aug; 116(6):900-8. PubMed ID: 20457870
[TBL] [Abstract][Full Text] [Related]
9. Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy.
Aiuti A; Cassani B; Andolfi G; Mirolo M; Biasco L; Recchia A; Urbinati F; Valacca C; Scaramuzza S; Aker M; Slavin S; Cazzola M; Sartori D; Ambrosi A; Di Serio C; Roncarolo MG; Mavilio F; Bordignon C
J Clin Invest; 2007 Aug; 117(8):2233-40. PubMed ID: 17671653
[TBL] [Abstract][Full Text] [Related]
10. An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation.
Ryu BY; Evans-Galea MV; Gray JT; Bodine DM; Persons DA; Nienhuis AW
Blood; 2008 Feb; 111(4):1866-75. PubMed ID: 17991809
[TBL] [Abstract][Full Text] [Related]
11. Success for gene therapy: render unto Caesar that which is Caesar's.
Qiao J; Diaz RM; Vile RG
Genome Biol; 2004; 5(8):237. PubMed ID: 15287968
[TBL] [Abstract][Full Text] [Related]
12. Foamy Virus Vector Carries a Strong Insulator in Its Long Terminal Repeat Which Reduces Its Genotoxic Potential.
Goodman MA; Arumugam P; Pillis DM; Loberg A; Nasimuzzaman M; Lynn D; van der Loo JCM; Dexheimer PJ; Keddache M; Bauer TR; Hickstein DD; Russell DW; Malik P
J Virol; 2018 Jan; 92(1):. PubMed ID: 29046446
[TBL] [Abstract][Full Text] [Related]
13. Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.
Wu C; Dunbar CE
Front Med; 2011 Dec; 5(4):356-71. PubMed ID: 22198747
[TBL] [Abstract][Full Text] [Related]
14. Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.
Pike-Overzet K; de Ridder D; Weerkamp F; Baert MR; Verstegen MM; Brugman MH; Howe SJ; Reinders MJ; Thrasher AJ; Wagemaker G; van Dongen JJ; Staal FJ
Leukemia; 2007 Apr; 21(4):754-63. PubMed ID: 17268520
[TBL] [Abstract][Full Text] [Related]
15. Gene therapy resumes.
Novak K
Nat Rev Cancer; 2002 Nov; 2(11):813. PubMed ID: 12442759
[No Abstract] [Full Text] [Related]
16. Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus.
Yamada K; Tsukahara T; Yoshino K; Kojima K; Agawa H; Yamashita Y; Amano Y; Hatta M; Matsuzaki Y; Kurotori N; Wakui K; Fukushima Y; Osada R; Shiozawa T; Sakashita K; Koike K; Kumaki S; Tanaka N; Takeshita T
Retrovirology; 2009 Sep; 6():79. PubMed ID: 19725963
[TBL] [Abstract][Full Text] [Related]
17. Gene therapy for severe combined immunodeficiencies.
Gaspar HB; Thrasher AJ
Expert Opin Biol Ther; 2005 Sep; 5(9):1175-82. PubMed ID: 16120048
[TBL] [Abstract][Full Text] [Related]
18. Medicine. Gene therapy--new challenges ahead.
Williams DA; Baum C
Science; 2003 Oct; 302(5644):400-1. PubMed ID: 14563994
[TBL] [Abstract][Full Text] [Related]
19. Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.
Baum C; von Kalle C; Staal FJ; Li Z; Fehse B; Schmidt M; Weerkamp F; Karlsson S; Wagemaker G; Williams DA
Mol Ther; 2004 Jan; 9(1):5-13. PubMed ID: 14741772
[TBL] [Abstract][Full Text] [Related]
20. Genotoxicity of retroviral integration in hematopoietic cells.
Nienhuis AW; Dunbar CE; Sorrentino BP
Mol Ther; 2006 Jun; 13(6):1031-49. PubMed ID: 16624621
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
